GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of CYP3A4 mRNA | PMID:15833926 PMID:29301061 | CYP3A4 | increases activity | EXP | | 6480464 | CTD | sodium arsenite results in increased activity of CYP3A4 protein | PMID:19084030 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of CYP3A4 mRNA; sodium arsenite results in increased expression of CYP3A4 protein | PMID:19084030 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CYP3A4 mRNA; sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein]; sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A4 protein]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; sodium arsenite results in decreased expression of and results in decreased activity of CYP3A4 protein | PMID:15833926 PMID:22310326 PMID:35747940 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |