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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:18882
Term: 1,2-dichloroethene
Definition: A chloroethene that has formula C2H2Cl2.
Chemical ID: MESH:C035384
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityISOCyp3a2 (Rattus norvegicus)6480464CTD1,2-dichloroethylene results in decreased activity of CYP3A2 proteinPMID:9493318
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTD1,2-dichloroethylene results in decreased expression of CYP3A2 proteinPMID:9493318
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