GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases activity | EXP | | 6480464 | CTD | Amiodarone results in decreased activity of CYP3A4 protein | PMID:15304522 PMID:16449812 PMID:22652334 | CYP3A4 | decreases ethylation | EXP | | 6480464 | CTD | CYP3A4 protein results in decreased ethylation of Amiodarone | PMID:7905403 | CYP3A4 | increases degradation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased degradation of Amiodarone | PMID:32305697 | CYP3A4 | increases metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Amiodarone | PMID:15869686 PMID:16449812 PMID:22785256 PMID:27485346 PMID:8445979 | CYP3A4 | increases response to substance | EXP | | 6480464 | CTD | CYP3A4 protein results in increased susceptibility to Amiodarone | PMID:21540358 PMID:26477383 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CD86 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of CXCL8 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of TNF protein; [CYP3A4 protein results in increased metabolism of Amiodarone] which results in increased abundance of mono-N-desethylamiodarone; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] | PMID:15869686 PMID:19299527 PMID:22652334 PMID:22785256 PMID:27485346 PMID:34273450 | CYP3A4 | increases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Amiodarone results in increased expression of CYP3A4 mRNA | PMID:19224547 | | ||||||||||||||||||||||
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