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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of PaclitaxelPMID:15901749
CYP3A4decreases activityEXP 6480464CTDPaclitaxel results in decreased activity of CYP3A4 proteinPMID:19909766
CYP3A4increases activityEXP 6480464CTDPaclitaxel results in increased activity of CYP3A4 proteinPMID:12065438 PMID:18839173
CYP3A4increases expressionEXP 6480464CTDPaclitaxel results in increased expression of CYP3A4 mRNA; Paclitaxel results in increased expression of CYP3A4 proteinPMID:15650019 PMID:16819505 PMID:17438109 PMID:18839173 PMID:23707768
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of PaclitaxelPMID:19695866
CYP3A4increases oxidationEXP 6480464CTDCYP3A4 protein results in increased oxidation of PaclitaxelPMID:12237780
CYP3A4multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel]PMID:12237780 PMID:16819505 PMID:17438109 PMID:19695866
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDPaclitaxel results in increased expression of CYP3A4 proteinPMID:15918522
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTDPlant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]PMID:15918522
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