GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in decreased expression of CYP3A4 mRNA | PMID:19695866 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel]; Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Oxygen deficiency results in decreased expression of and results in decreased activity of CYP3A4 protein | PMID:19695866 PMID:21566342 PMID:21766881 | | ||||||||||||||||||||||
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