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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:6402
Term: leflunomide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical ID: MESH:C045463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to leflunomidePMID:21540358
CYP3A4multiple interactionsEXP 6480464CTD[leflunomide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in decreased susceptibility to leflunomidePMID:25455453 PMID:25860621
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