GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | affects metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein affects the metabolism of Diltiazem | PMID:15286053 | CYP3A4 | decreases activity | EXP | | 6480464 | CTD | Diltiazem results in decreased activity of CYP3A4 protein | PMID:22652334 | CYP3A4 | decreases methylation | EXP | | 6480464 | CTD | CYP3A4 protein results in decreased methylation of Diltiazem | PMID:15499178 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Diltiazem inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]]; potassium ferricyanide inhibits the reaction [Diltiazem results in decreased activity of CYP3A4 protein]; potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]] | PMID:19299527 PMID:22652334 | |
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