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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:9674
Term: triazolam
Definition: A triazolobenzodiazepine that has formula C17H12Cl2N4.
Chemical ID: MESH:D014229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of TriazolamPMID:15286053 PMID:16042670
CYP3A4multiple interactionsEXP 6480464CTD[Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam]; Triazolam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]PMID:10952769 PMID:15863898 PMID:19299527 PMID:22447115
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