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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDMonocrotaline results in increased expression of CYP3A4 mRNAPMID:32682830
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of MonocrotalinePMID:33884520
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to MonocrotalinePMID:32910235
CYP3A4multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA; [Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]PMID:19818743 PMID:32682830 PMID:33884520
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