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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:ephrin - ephrin receptor bidirectional signaling axis
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Accession:PW:0000322 term browser browse the term
Definition:Ephrins and their receptors constitute a bidirectional signaling pathway transducing forward signals through the receptors and reverse signals through the ephrins that influence the behavior of both interacting cells. The Eph/ephrin axis plays important roles in cell morphology, adhesion and migration. Its disruption has been implicated in several human cancers.
Synonyms:exact_synonym: eph/ephrin receptor bidirectional signaling axis
 related_synonym: EPH-Ephrin signaling;   ephrin receptor signaling pathway


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ephrin - ephrin receptor bidirectional signaling axis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP1 acid phosphatase 1 EXP PID PID:200216 NCBI chr 2:264,947...278,283
Ensembl chr 2:264,140...278,283 		JBrowse link
G ARHGAP35 Rho GTPase activating protein 35 EXP PID PID:200216 NCBI chr19:46,860,997...47,005,077
Ensembl chr19:46,860,997...47,005,077 		JBrowse link
G ARHGEF15 Rho guanine nucleotide exchange factor 15 EXP PID PID:200142 NCBI chr17:8,310,241...8,322,511
Ensembl chr17:8,310,241...8,322,514 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member EXP PID PID:200216 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053 		JBrowse link
G BLK BLK proto-oncogene, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr 8:11,494,387...11,564,599
Ensembl chr 8:11,486,894...11,564,599 		JBrowse link
G CBL Cbl proto-oncogene EXP PID PID:200142 PID:200216 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926 		JBrowse link
G CDC42 cell division cycle 42 EXP PID PID:200052 NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360 		JBrowse link
G CDK5 cyclin dependent kinase 5 EXP PID PID:200142 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein EXP PID PID:200142 NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162 		JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein EXP PID PID:200142 NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 EXP PID PID:200204 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G DNM1 dynamin 1 EXP PID PID:200052 PID:200204 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248 		JBrowse link
G EFNA1 ephrin A1 ISS
EXP		 PID
RGD		 PMID:12615978 PID:200142 PID:200216, RGD:1299268 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899 		JBrowse link
G EFNA2 ephrin A2 EXP PID PID:200142 NCBI chr19:1,284,227...1,301,431
Ensembl chr19:1,285,873...1,301,431 		JBrowse link
G EFNA3 ephrin A3 EXP PID PID:200142 NCBI chr 1:155,078,837...155,087,538
Ensembl chr 1:155,078,837...155,087,538 		JBrowse link
G EFNA5 ephrin A5 EXP PID PID:200052 PID:200059 PID:200142 NCBI chr 5:107,376,894...107,670,937
Ensembl chr 5:107,376,894...107,670,937 		JBrowse link
G EFNB1 ephrin B1 ISS
EXP		 PID
RGD		 PMID:12139920 PID:200052 PID:200204, RGD:727396 NCBI chr  X:68,829,021...68,842,160
Ensembl chr  X:68,829,021...68,842,160 		JBrowse link
G EFNB2 ephrin B2 EXP PID PID:200052 PID:200204 NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662 		JBrowse link
G EFNB3 ephrin B3 EXP PID PID:200052 NCBI chr17:7,705,202...7,711,372
Ensembl chr17:7,705,202...7,711,372 		JBrowse link
G EPHA1 EPH receptor A1 EXP PID PID:200142 NCBI chr 7:143,391,129...143,408,856
Ensembl chr 7:143,390,289...143,408,856 		JBrowse link
G EPHA2 EPH receptor A2 EXP PID PID:200142 PID:200216 NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069 		JBrowse link
G EPHA3 EPH receptor A3 ISS
EXP		 PID
RGD		 PMID:9458884 PID:200142, RGD:68243 NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134 		JBrowse link
G EPHA4 EPH receptor A4 EXP PID PID:200142 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202 		JBrowse link
G EPHA5 EPH receptor A5 EXP PID PID:200059 PID:200142 NCBI chr 4:65,319,567...65,670,489
Ensembl chr 4:65,319,563...65,670,495 		JBrowse link
G EPHA6 EPH receptor A6 EXP PID PID:200142 NCBI chr 3:96,814,594...97,761,532
Ensembl chr 3:96,814,581...97,761,532 		JBrowse link
G EPHA7 EPH receptor A7 ISS
EXP		 PID
RGD		 PMID:7731712 PID:200142, RGD:70732 NCBI chr 6:93,240,020...93,419,559
Ensembl chr 6:93,240,020...93,419,687 		JBrowse link
G EPHA8 EPH receptor A8 EXP PID PID:200142 NCBI chr 1:22,563,489...22,603,595
Ensembl chr 1:22,563,489...22,603,595 		JBrowse link
G EPHB1 EPH receptor B1 EXP PID PID:200052 PID:200204 NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467 		JBrowse link
G EPHB2 EPH receptor B2 EXP PID PID:200052 PID:200204 NCBI chr 1:22,710,838...22,921,500
Ensembl chr 1:22,710,839...22,921,500 		JBrowse link
G EPHB3 EPH receptor B3 EXP PID PID:200052 NCBI chr 3:184,561,785...184,582,408
Ensembl chr 3:184,561,785...184,582,408 		JBrowse link
G EPHB4 EPH receptor B4 EXP PID PID:200052 PID:200204 NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523 		JBrowse link
G FGA fibrinogen alpha chain EXP PID PID:200204 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742 		JBrowse link
G FGB fibrinogen beta chain EXP PID PID:200204 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807 		JBrowse link
G FGG fibrinogen gamma chain EXP PID PID:200204 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967 		JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr 1:27,612,064...27,635,185
Ensembl chr 1:27,612,064...27,635,185 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase EXP PID PID:200059 PID:200142 PID:200204 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G GRB2 growth factor receptor bound protein 2 EXP PID PID:200052 PID:200216 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G GRB7 growth factor receptor bound protein 7 EXP PID PID:200052 NCBI chr17:39,737,938...39,747,285
Ensembl chr17:39,737,927...39,747,291 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 EXP PID PID:200052 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856 		JBrowse link
G HRAS HRas proto-oncogene, GTPase EXP PID PID:200052 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 EXP PID PID:200216 NCBI chr11:72,223,563...72,239,147
Ensembl chr11:72,223,701...72,239,147 		JBrowse link
G ITGA2B integrin subunit alpha 2b EXP PID PID:200204 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649 		JBrowse link
G ITGB3 integrin subunit beta 3 EXP PID PID:200204 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743 		JBrowse link
G ITSN1 intersectin 1 EXP PID PID:200052 NCBI chr21:33,642,501...33,899,861
Ensembl chr21:33,642,400...33,899,861 		JBrowse link
G KALRN kalirin RhoGEF kinase EXP PID PID:200052 NCBI chr 3:124,033,369...124,726,325
Ensembl chr 3:124,033,369...124,726,325 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr 8:55,879,835...56,014,169
Ensembl chr 8:55,879,835...56,014,169 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 EXP PID PID:200052 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 EXP PID PID:200204 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 EXP PID PID:200204 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 EXP PID PID:200052 NCBI chr 2:101,697,707...101,894,690
Ensembl chr 2:101,696,850...101,894,690 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP PID PID:200052 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 EXP PID PID:200052 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 EXP PID PID:200204 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G NCK1 NCK adaptor protein 1 EXP PID PID:200052 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606 		JBrowse link
G NCK2 NCK adaptor protein 2 EXP PID PID:200204 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274 		JBrowse link
G NGEF neuronal guanine nucleotide exchange factor EXP PID PID:200142 NCBI chr 2:232,878,701...233,013,256
Ensembl chr 2:232,878,701...233,013,256 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase EXP PID PID:200052 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 EXP PID PID:200052 PID:200216 NCBI chr11:77,322,017...77,530,009
Ensembl chr11:77,322,017...77,474,635 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha EXP PID PID:200052 PID:200204 PID:200216 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma EXP PID PID:200142 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 EXP PID PID:200052 PID:200204 PID:200216 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 EXP PID PID:200142 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 EXP PID PID:200142 NCBI chr17:8,802,722...8,867,677
Ensembl chr17:8,802,722...8,867,677 		JBrowse link
G PLCG1 phospholipase C gamma 1 EXP PID PID:200142 NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801 		JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 EXP PID PID:200204 NCBI chr 4:86,594,315...86,815,161
Ensembl chr 4:86,594,315...86,815,171 		JBrowse link
G PXN paxillin EXP PID PID:200052 NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771 		JBrowse link
G RAC1 Rac family small GTPase 1 EXP PID PID:200052 PID:200204 PID:200216 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family EXP PID PID:200052 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691 		JBrowse link
G RAP1B RAP1B, member of RAS oncogene family EXP PID PID:200052 NCBI chr12:68,610,899...68,671,901
Ensembl chr12:68,610,855...68,671,901 		JBrowse link
G RASA1 RAS p21 protein activator 1 EXP PID PID:200052 NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931 		JBrowse link
G RGS3 regulator of G protein signaling 3 EXP PID PID:200204 NCBI chr 9:113,444,730...113,597,738
Ensembl chr 9:113,444,731...113,597,743 		JBrowse link
G RHOA ras homolog family member A EXP PID PID:200142 PID:200216 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 EXP PID PID:200052 PID:200142 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G RRAS RAS related EXP PID PID:200052 NCBI chr19:49,635,292...49,640,143
Ensembl chr19:49,635,292...49,640,143 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase EXP PID PID:200052 PID:200142 PID:200204 PID:200216 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SYNJ1 synaptojanin 1 EXP PID PID:200052 NCBI chr21:32,628,759...32,728,394
Ensembl chr21:32,628,759...32,728,040 		JBrowse link
G TF transferrin EXP PID PID:200052 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 EXP PID PID:200204 PID:200216 NCBI chr21:31,118,418...31,559,087
Ensembl chr21:31,118,416...31,559,977 		JBrowse link
G VAV2 vav guanine nucleotide exchange factor 2 EXP PID PID:200142 PID:200216 NCBI chr 9:133,761,894...133,992,324
Ensembl chr 9:133,761,894...133,992,604 		JBrowse link
G VAV3 vav guanine nucleotide exchange factor 3 EXP PID PID:200142 PID:200216 NCBI chr 1:107,571,161...107,965,180
Ensembl chr 1:107,571,161...107,965,180 		JBrowse link
G WASL WASP like actin nucleation promoting factor EXP PID PID:200052 NCBI chr 7:123,681,943...123,749,003
Ensembl chr 7:123,681,943...123,749,003 		JBrowse link
G YES1 YES proto-oncogene 1, Src family tyrosine kinase EXP PID PID:200142 PID:200204 NCBI chr18:721,588...812,753
Ensembl chr18:721,588...812,546 		JBrowse link
altered ephrin - ephrin receptor bidirectional signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EFNA1 ephrin A1 ISS RGD PMID:15561600 RGD:1304509 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899 		JBrowse link
G EFNB1 ephrin B1 ISS RGD PMID:15561600 RGD:1304509 NCBI chr  X:68,829,021...68,842,160
Ensembl chr  X:68,829,021...68,842,160 		JBrowse link
G EPHA3 EPH receptor A3 ISS RGD PMID:15561600 RGD:1304509 NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134 		JBrowse link
G EPHA7 EPH receptor A7 ISS RGD PMID:15561600 RGD:1304509 NCBI chr 6:93,240,020...93,419,559
Ensembl chr 6:93,240,020...93,419,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    signaling pathway 2506
      cell adhesion signaling pathway 417
        cell-cell signaling pathway 252
          ephrin - ephrin receptor bidirectional signaling axis 84
            altered ephrin - ephrin receptor bidirectional signaling pathway 4
paths to the root