FGR (FGR proto-oncogene, Src family tyrosine kinase) - Rat Genome Database
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Gene: FGR (FGR proto-oncogene, Src family tyrosine kinase) Homo sapiens
Analyze
Symbol: FGR
Name: FGR proto-oncogene, Src family tyrosine kinase
RGD ID: 733253
HGNC Page HGNC
Description: Exhibits Fc-gamma receptor I complex binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; and protein phosphorylation. Localizes to aggresome and plasma membrane. Colocalizes with cytoskeleton.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; feline Gardner-Rasheed sarcoma viral oncogene homolog; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; p55-c-fgr protein; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,612,064 - 27,635,185 (-)EnsemblGRCh38hg38GRCh38
GRCh38127,612,064 - 27,635,561 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,938,575 - 27,961,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,811,387 - 27,834,314 (-)NCBINCBI36hg18NCBI36
Build 34127,622,952 - 27,634,715NCBI
Celera126,334,465 - 26,357,390 (-)NCBI
Cytogenetic Map1p35.3NCBI
HuRef126,195,016 - 26,217,930 (-)NCBIHuRef
CHM1_1128,054,060 - 28,076,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
cisplatin  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dichlorine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (ISO)
fenofibrate  (ISO)
genistein  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phosphatidic acid  (EXP)
ponatinib  (EXP)
resveratrol  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
tamibarotene  (EXP)
Tesaglitazar  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vincristine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:1339476   PMID:1373875   PMID:1652975   PMID:1690869   PMID:1826268   PMID:1847500   PMID:2154410   PMID:2181286   PMID:2581127   PMID:2852026   PMID:2995972   PMID:3003578  
PMID:3023853   PMID:3275868   PMID:3330776   PMID:3922831   PMID:7515063   PMID:7519620   PMID:7565724   PMID:7678701   PMID:7721825   PMID:7726865   PMID:7812001   PMID:8313462  
PMID:8327512   PMID:8603737   PMID:8612628   PMID:8753773   PMID:8805332   PMID:8824280   PMID:8867673   PMID:9208935   PMID:10066823   PMID:10080533   PMID:10229804   PMID:10358777  
PMID:10527858   PMID:10702640   PMID:10739672   PMID:10861086   PMID:10973280   PMID:11071635   PMID:11162638   PMID:11526478   PMID:11546677   PMID:11672534   PMID:11744621   PMID:11823534  
PMID:11928806   PMID:12096713   PMID:12244095   PMID:12387730   PMID:12387813   PMID:12435267   PMID:12468645   PMID:12473651   PMID:12477932   PMID:14702039   PMID:15098032   PMID:15190072  
PMID:15459198   PMID:15489334   PMID:15536084   PMID:15561106   PMID:15707590   PMID:15723811   PMID:15919723   PMID:16273093   PMID:16344560   PMID:16684964   PMID:16710414   PMID:16921024  
PMID:17164290   PMID:17845055   PMID:20056178   PMID:20098747   PMID:20458337   PMID:20624904   PMID:20804422   PMID:21300758   PMID:21873635   PMID:21988832   PMID:22745667   PMID:22939624  
PMID:22973453   PMID:22974441   PMID:23131831   PMID:23867815   PMID:23896410   PMID:24162774   PMID:24658140   PMID:24728074   PMID:24860872   PMID:25402006   PMID:25972488   PMID:26186194  
PMID:27324824   PMID:28514442   PMID:28585144   PMID:29568343   PMID:29763550   PMID:29845934   PMID:30352950   PMID:31586073   PMID:31790499   PMID:31980649  


Genomics

Comparative Map Data
FGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,612,064 - 27,635,185 (-)EnsemblGRCh38hg38GRCh38
GRCh38127,612,064 - 27,635,561 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,938,575 - 27,961,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,811,387 - 27,834,314 (-)NCBINCBI36hg18NCBI36
Build 34127,622,952 - 27,634,715NCBI
Celera126,334,465 - 26,357,390 (-)NCBI
Cytogenetic Map1p35.3NCBI
HuRef126,195,016 - 26,217,930 (-)NCBIHuRef
CHM1_1128,054,060 - 28,076,993 (-)NCBICHM1_1
Fgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,701,406 - 132,729,204 (+)NCBIGRCm39mm39
GRCm39 Ensembl4132,701,406 - 132,729,221 (+)Ensembl
GRCm384132,974,095 - 133,001,893 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,974,095 - 133,001,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,530,010 - 132,557,808 (+)NCBIGRCm37mm9NCBIm37
MGSCv364132,246,204 - 132,273,882 (+)NCBImm8
Celera4131,136,566 - 131,164,622 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.11NCBI
Fgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,189,814 - 145,219,571 (+)NCBI
Rnor_6.0 Ensembl5151,172,206 - 151,199,745 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05151,172,189 - 151,199,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05154,839,086 - 154,866,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,119,455 - 152,147,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15152,129,494 - 152,157,096 (-)NCBI
Celera5143,612,003 - 143,639,441 (+)NCBICelera
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
Fgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,841,802 - 6,863,542 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,840,274 - 6,863,460 (-)NCBIChiLan1.0ChiLan1.0
FGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,918,758 - 27,941,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,918,758 - 27,941,678 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,872,781 - 26,895,751 (-)NCBIMhudiblu_PPA_v0panPan3
FGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl272,680,675 - 72,690,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1272,678,858 - 72,692,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647411,897,998 - 11,919,153 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,809,542 - 84,830,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,809,534 - 84,830,401 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,326,176 - 78,358,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,155,223 - 105,178,813 (+)NCBI
ChlSab1.1 Ensembl20105,165,043 - 105,179,067 (+)Ensembl
Fgr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476411,482,719 - 11,513,215 (-)NCBI

Position Markers
SHGC-74510  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,948,252 - 27,948,501UniSTSGRCh37
Build 36127,820,839 - 27,821,088RGDNCBI36
Celera126,343,917 - 26,344,166RGD
Cytogenetic Map1p36.2-p36.1UniSTS
HuRef126,204,459 - 26,204,708UniSTS
TNG Radiation Hybrid Map112556.0UniSTS
GeneMap99-GB4 RH Map195.57UniSTS
SHGC-74489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,938,871 - 27,939,058UniSTSGRCh37
Build 36127,811,458 - 27,811,645RGDNCBI36
Celera126,334,536 - 26,334,723RGD
Cytogenetic Map1p36.2-p36.1UniSTS
HuRef126,195,087 - 26,195,274UniSTS
TNG Radiation Hybrid Map112564.0UniSTS
GeneMap99-GB4 RH Map194.47UniSTS
GDB:549146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,939,416 - 27,939,632UniSTSGRCh37
Build 36127,812,003 - 27,812,219RGDNCBI36
Celera126,335,081 - 26,335,297RGD
Cytogenetic Map1p36.2-p36.1UniSTS
HuRef126,195,632 - 26,195,848UniSTS
UniSTS:24107  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,953,861 - 27,954,165UniSTSGRCh37
Build 36127,826,448 - 27,826,752RGDNCBI36
Celera126,349,526 - 26,349,828RGD
HuRef126,210,068 - 26,210,370UniSTS
SHGC-74509  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,951,792 - 27,951,985UniSTSGRCh37
Build 36127,824,379 - 27,824,572RGDNCBI36
Celera126,347,457 - 26,347,650RGD
Cytogenetic Map1p36.2-p36.1UniSTS
HuRef126,207,999 - 26,208,192UniSTS
TNG Radiation Hybrid Map112552.0UniSTS
GeneMap99-GB4 RH Map195.57UniSTS
SHGC-6996  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,954,970 - 27,955,106UniSTSGRCh37
Build 36127,827,557 - 27,827,693RGDNCBI36
Celera126,350,633 - 26,350,769RGD
Cytogenetic Map1p36.2-p36.1UniSTS
HuRef126,211,175 - 26,211,311UniSTS
FGR__5988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,938,611 - 27,939,481UniSTSGRCh37
Build 36127,811,198 - 27,812,068RGDNCBI36
Celera126,334,276 - 26,335,146RGD
HuRef126,194,827 - 26,195,697UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2473
Count of miRNA genes:692
Interacting mature miRNAs:799
Transcripts:ENST00000374003, ENST00000374004, ENST00000374005, ENST00000399173, ENST00000457296, ENST00000468038, ENST00000475472, ENST00000545953
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 161 161
Medium 627 1146 515 91 1566 49 1407 285 650 121 418 1041 43 1101 708 1
Low 1689 1671 1176 510 153 390 2733 1845 2977 255 926 358 120 103 2066 1
Below cutoff 31 6 10 6 50 9 148 36 42 12 37 83 6 14 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006710452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_946583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH001461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI771758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ448283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX495937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ834776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA139476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA952771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA960178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z13983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z13989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000374003   ⟹   ENSP00000363115
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,612,669 - 27,626,569 (-)Ensembl
RefSeq Acc Id: ENST00000374004   ⟹   ENSP00000363116
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,612,300 - 27,624,062 (-)Ensembl
RefSeq Acc Id: ENST00000374005   ⟹   ENSP00000363117
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,612,064 - 27,635,185 (-)Ensembl
RefSeq Acc Id: ENST00000399173   ⟹   ENSP00000382126
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,612,292 - 27,626,240 (-)Ensembl
RefSeq Acc Id: ENST00000457296   ⟹   ENSP00000407670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,615,514 - 27,626,135 (-)Ensembl
RefSeq Acc Id: ENST00000468038
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,623,407 - 27,626,240 (-)Ensembl
RefSeq Acc Id: ENST00000475472
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,623,384 - 27,635,134 (-)Ensembl
RefSeq Acc Id: NM_001042729   ⟹   NP_001036194
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,064 - 27,626,597 (-)NCBI
GRCh37127,938,800 - 27,961,727 (-)ENTREZGENE
Build 36127,811,387 - 27,825,693 (-)NCBI Archive
HuRef126,195,016 - 26,217,930 (-)ENTREZGENE
CHM1_1128,054,060 - 28,068,372 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001042747   ⟹   NP_001036212
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,064 - 27,626,251 (-)NCBI
GRCh37127,938,800 - 27,961,727 (-)ENTREZGENE
Build 36127,811,387 - 27,825,338 (-)NCBI Archive
HuRef126,195,016 - 26,217,930 (-)ENTREZGENE
CHM1_1128,054,060 - 28,068,017 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005248   ⟹   NP_005239
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,064 - 27,635,185 (-)NCBI
GRCh37127,938,800 - 27,961,727 (-)ENTREZGENE
Build 36127,811,387 - 27,834,314 (-)NCBI Archive
HuRef126,195,016 - 26,217,930 (-)ENTREZGENE
CHM1_1128,054,060 - 28,076,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006710452   ⟹   XP_006710515
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541010   ⟹   XP_011539312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541011   ⟹   XP_011539313
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541012   ⟹   XP_011539314
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541013   ⟹   XP_011539315
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,613,283 - 27,635,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541014   ⟹   XP_011539316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,619,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017000673   ⟹   XP_016856162
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017000674   ⟹   XP_016856163
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,217 (-)NCBI
Sequence:
RefSeq Acc Id: XR_946583
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,612,289 - 27,635,184 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005239   ⟸   NM_005248
- UniProtKB: P09769 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001036194   ⟸   NM_001042729
- UniProtKB: P09769 (UniProtKB/Swiss-Prot),   P78453 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001036212   ⟸   NM_001042747
- UniProtKB: P09769 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006710515   ⟸   XM_006710452
- Peptide Label: isoform X1
- UniProtKB: P09769 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011539312   ⟸   XM_011541010
- Peptide Label: isoform X1
- UniProtKB: P09769 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011539314   ⟸   XM_011541012
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011539313   ⟸   XM_011541011
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011539316   ⟸   XM_011541014
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011539315   ⟸   XM_011541013
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016856163   ⟸   XM_017000674
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016856162   ⟸   XM_017000673
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000382126   ⟸   ENST00000399173
RefSeq Acc Id: ENSP00000363116   ⟸   ENST00000374004
RefSeq Acc Id: ENSP00000363117   ⟸   ENST00000374005
RefSeq Acc Id: ENSP00000363115   ⟸   ENST00000374003
RefSeq Acc Id: ENSP00000407670   ⟸   ENST00000457296
Protein Domains
Protein kinase   SH2   SH3

Promoters
RGD ID:6854688
Promoter ID:EPDNEW_H509
Type:initiation region
Name:FGR_1
Description:FGR proto-oncogene, Src family tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,635,143 - 27,635,203EPDNEW
RGD ID:6785582
Promoter ID:HG_KWN:1583
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC001BOI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,814,266 - 27,815,217 (-)MPROMDB
RGD ID:6785583
Promoter ID:HG_KWN:1584
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC001BOJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,822,661 - 27,823,957 (-)MPROMDB
RGD ID:6809548
Promoter ID:HG_ACW:1229
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:FGR.GAPR07,   FGR.KAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,824,316 - 27,824,816 (-)MPROMDB
RGD ID:6785584
Promoter ID:HG_KWN:1585
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_001042729,   NM_001042747,   OTTHUMT00000009774,   OTTHUMT00000009777,   OTTHUMT00000009778
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,825,341 - 27,826,467 (-)MPROMDB
RGD ID:6814445
Promoter ID:HG_XEF:130
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001098991
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,829,866 - 27,830,366 (-)MPROMDB
RGD ID:6809550
Promoter ID:HG_ACW:1231
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:FGR.HAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,833,299 - 27,833,799 (-)MPROMDB
RGD ID:6785585
Promoter ID:HG_KWN:1586
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000009772,   OTTHUMT00000009776
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,833,961 - 27,834,461 (-)MPROMDB
RGD ID:6851426
Promoter ID:EP73513
Type:initiation region
Name:HS_FGR
Description:Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,834,242 - 27,834,302EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-35.2(chr1:26963045-32279045)x3 copy number gain See cases [RCV000051801] Chr1:26963045..32279045 [GRCh38]
Chr1:27289536..32744646 [GRCh37]
Chr1:27162123..32517233 [NCBI36]
Chr1:1p36.11-35.2
pathogenic
GRCh38/hg38 1p36.11-35.3(chr1:26807012-27685191)x1 copy number loss See cases [RCV000053799] Chr1:26807012..27685191 [GRCh38]
Chr1:27133503..28011702 [GRCh37]
Chr1:27006090..27884289 [NCBI36]
Chr1:1p36.11-35.3
pathogenic
GRCh38/hg38 1p35.3(chr1:27601122-27889441)x1 copy number loss See cases [RCV000053801] Chr1:27601122..27889441 [GRCh38]
Chr1:27927633..28215952 [GRCh37]
Chr1:27800220..28088539 [NCBI36]
Chr1:1p35.3
pathogenic
NM_001042729.1(FGR):c.891C>T (p.Thr297=) single nucleotide variant Malignant melanoma [RCV000060168] Chr1:27615561 [GRCh38]
Chr1:27942072 [GRCh37]
Chr1:27814659 [NCBI36]
Chr1:1p35.3
not provided
GRCh38/hg38 1p36.11-35.3(chr1:26854636-27645829)x1 copy number loss See cases [RCV000137657] Chr1:26854636..27645829 [GRCh38]
Chr1:27181127..27972340 [GRCh37]
Chr1:27053714..27844927 [NCBI36]
Chr1:1p36.11-35.3
uncertain significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
GRCh38/hg38 1p36.11-35.3(chr1:27429343-27699564)x1 copy number loss See cases [RCV000139133] Chr1:27429343..27699564 [GRCh38]
Chr1:27755852..28026075 [GRCh37]
Chr1:27628439..27898662 [NCBI36]
Chr1:1p36.11-35.3
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.11-35.3(chr1:27488298-28138628)x1 copy number loss See cases [RCV000447976] Chr1:27488298..28138628 [GRCh37]
Chr1:1p36.11-35.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_005248.3(FGR):c.533-8C>G single nucleotide variant not provided [RCV000948535] Chr1:27617014 [GRCh38]
Chr1:27943525 [GRCh37]
Chr1:1p35.3
benign
NM_005248.3(FGR):c.366C>T (p.Ser122=) single nucleotide variant not provided [RCV000950364] Chr1:27621621 [GRCh38]
Chr1:27948132 [GRCh37]
Chr1:1p35.3
benign
NM_005248.3(FGR):c.352C>T (p.Arg118Trp) single nucleotide variant not provided [RCV001263546] Chr1:27621635 [GRCh38]
Chr1:27948146 [GRCh37]
Chr1:1p35.3
uncertain significance
NM_005248.3(FGR):c.1573C>T (p.Pro525Ser) single nucleotide variant not provided [RCV001263547] Chr1:27612931 [GRCh38]
Chr1:27939442 [GRCh37]
Chr1:1p35.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3697 AgrOrtholog
COSMIC FGR COSMIC
Ensembl Genes ENSG00000000938 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000363115 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000363116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000363117 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000382126 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000407670 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000374003 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000374004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000374005 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000399173 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000457296 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000000938 GTEx
HGNC ID HGNC:3697 ENTREZGENE
Human Proteome Map FGR Human Proteome Map
InterPro Fgr_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2268 ENTREZGENE
OMIM 164940 OMIM
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28135 PharmGKB
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FGR_HUMAN UniProtKB/Swiss-Prot
  L8E733_HUMAN UniProtKB/TrEMBL
  P09769 ENTREZGENE
  P78453 ENTREZGENE, UniProtKB/TrEMBL
  P78483_HUMAN UniProtKB/TrEMBL
  Q5TGY6_HUMAN UniProtKB/TrEMBL
UniProt Secondary D3DPL7 UniProtKB/Swiss-Prot
  Q9UIQ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 FGR  FGR proto-oncogene, Src family tyrosine kinase    feline Gardner-Rasheed sarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED
2013-07-16 FGR  feline Gardner-Rasheed sarcoma viral oncogene homolog    Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog  Symbol and/or name change 5135510 APPROVED
2011-08-16 FGR  Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog  FGR  Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog  Symbol and/or name change 5135510 APPROVED