Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: NCK1 (NCK adaptor protein 1) Homo sapiens
Symbol: NCK1
Name: NCK adaptor protein 1
Description: Exhibits several functions, including SH3/SH2 adaptor activity; eukaryotic initiation factor eIF2 binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of cellular macromolecule biosynthetic process; and regulation of response to endoplasmic reticulum stress. Localizes to several cellular components, including the endoplasmic reticulum; protein phosphatase type 1 complex; and ribosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK tyrosine kinase; nck-1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
Mus musculus (house mouse) : Nck1 (non-catalytic region of tyrosine kinase adaptor protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nck1 (NCK adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nck1 (NCK adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCK1 (NCK adaptor protein 1)
Canis lupus familiaris (dog) : NCK1 (NCK adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nck1 (NCK adaptor protein 1)
Sus scrofa (pig) : NCK1 (NCK adaptor protein 1)
Chlorocebus sabaeus (African green monkey) : NCK1 (NCK adaptor protein 1)
Heterocephalus glaber (naked mole-rat) : Nck1 (NCK adaptor protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3136,862,208 - 136,951,606 (+)EnsemblGRCh38hg38GRCh38
GRCh383136,862,208 - 136,951,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373136,581,050 - 136,670,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,063,763 - 138,150,658 (+)NCBINCBI36hg18NCBI36
Build 343138,063,770 - 138,150,665NCBI
Celera3135,007,352 - 135,094,246 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3133,957,144 - 134,043,755 (+)NCBIHuRef
CHM1_13136,544,712 - 136,634,091 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321736
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.