NCK1 (NCK adaptor protein 1) - Rat Genome Database

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Gene: NCK1 (NCK adaptor protein 1) Homo sapiens
Analyze
Symbol: NCK1
Name: NCK adaptor protein 1
RGD ID: 1321736
HGNC Page HGNC
Description: Enables several functions, including eukaryotic initiation factor eIF2 binding activity; protein kinase inhibitor activity; and receptor tyrosine kinase binding activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of cellular macromolecule biosynthetic process; and regulation of response to endoplasmic reticulum stress. Located in several cellular components, including cytosol; endoplasmic reticulum; and ribosome. Part of protein phosphatase type 1 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK tyrosine kinase; nck-1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3136,862,208 - 136,951,606 (+)EnsemblGRCh38hg38GRCh38
GRCh383136,862,208 - 136,951,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373136,581,050 - 136,670,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,063,763 - 138,150,658 (+)NCBINCBI36hg18NCBI36
Build 343138,063,770 - 138,150,665NCBI
Celera3135,007,352 - 135,094,246 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3133,957,144 - 134,043,755 (+)NCBIHuRef
CHM1_13136,544,712 - 136,631,607 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament bundle assembly  (IEA)
actin filament organization  (IEA,ISO)
barbed-end actin filament capping  (IEA)
cell migration  (IBA,ISO)
ephrin receptor signaling pathway  (IEA,ISO)
lamellipodium assembly  (IEA,ISO)
negative regulation of catalytic activity  (IEA)
negative regulation of cell death  (IDA)
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (IBA,IDA)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of peptidyl-serine phosphorylation  (IDA)
negative regulation of PERK-mediated unfolded protein response  (IBA,IDA)
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IDA)
peptidyl-serine dephosphorylation  (IDA)
positive regulation of actin filament polymerization  (IMP,ISO)
positive regulation of cap-dependent translational initiation  (IDA)
positive regulation of cap-independent translational initiation  (IDA)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IBA,IDA)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of T cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of translation in response to endoplasmic reticulum stress  (IBA,IDA)
regulation of cell migration  (IEA,ISO)
response to other organism  (IEA,ISO)
signal complex assembly  (NAS)
signal transduction  (IBA)
substrate-dependent cell migration, cell extension  (IEA,ISO)
T cell activation  (IMP)

Cellular Component

References

Additional References at PubMed
PMID:1333046   PMID:1333047   PMID:1448108   PMID:2107526   PMID:7517397   PMID:7565724   PMID:7706279   PMID:7806213   PMID:7862111   PMID:7926767   PMID:7956370   PMID:8561895  
PMID:8605018   PMID:8662998   PMID:8810325   PMID:8824201   PMID:8879209   PMID:8890167   PMID:8910519   PMID:9006905   PMID:9010224   PMID:9024622   PMID:9135144   PMID:9233798  
PMID:9314836   PMID:9344857   PMID:9346925   PMID:9362449   PMID:9405464   PMID:9430661   PMID:9600074   PMID:9694849   PMID:9697839   PMID:9737977   PMID:9837978   PMID:9843378  
PMID:9846482   PMID:9851874   PMID:9891069   PMID:10022833   PMID:10026169   PMID:10202139   PMID:10204582   PMID:10206341   PMID:10229072   PMID:10330411   PMID:10372803   PMID:10391903  
PMID:10409713   PMID:10428862   PMID:10508618   PMID:10521462   PMID:10671570   PMID:10747096   PMID:10747847   PMID:10766742   PMID:10805734   PMID:10808124   PMID:10829062   PMID:10967110  
PMID:11024037   PMID:11157752   PMID:11160719   PMID:11240126   PMID:11278241   PMID:11278436   PMID:11278500   PMID:11278553   PMID:11279207   PMID:11340081   PMID:11418237   PMID:11418612  
PMID:11483358   PMID:11487585   PMID:11494134   PMID:11533668   PMID:11551902   PMID:11557983   PMID:11689432   PMID:11724572   PMID:11741599   PMID:11950595   PMID:11959995   PMID:12007418  
PMID:12074588   PMID:12087092   PMID:12091389   PMID:12110186   PMID:12135674   PMID:12149262   PMID:12154000   PMID:12181570   PMID:12214271   PMID:12379115   PMID:12477932   PMID:12620186  
PMID:12819203   PMID:14517291   PMID:14559906   PMID:14676213   PMID:14702039   PMID:14757753   PMID:15051508   PMID:15144186   PMID:15187089   PMID:15297625   PMID:15342556   PMID:15388330  
PMID:15469942   PMID:15489334   PMID:15556869   PMID:15558067   PMID:15696170   PMID:15908432   PMID:15929943   PMID:15951569   PMID:16137687   PMID:16273093   PMID:16344560   PMID:16374509  
PMID:16503409   PMID:16525419   PMID:16543952   PMID:16595635   PMID:16636066   PMID:16636290   PMID:16729043   PMID:16835242   PMID:16966330   PMID:17474147   PMID:17617578   PMID:17803907  
PMID:17868192   PMID:17906149   PMID:17944934   PMID:17984209   PMID:18067320   PMID:18212058   PMID:18296648   PMID:18320063   PMID:18835251   PMID:18955169   PMID:19242519   PMID:19523119  
PMID:19807924   PMID:20079431   PMID:20129698   PMID:20237496   PMID:20562827   PMID:20800603   PMID:20850195   PMID:21309750   PMID:21397687   PMID:21536650   PMID:21664272   PMID:21707536  
PMID:21719533   PMID:21725281   PMID:21873635   PMID:21880263   PMID:21900206   PMID:21988832   PMID:22074159   PMID:22132889   PMID:22267732   PMID:22323535   PMID:22327338   PMID:22534133  
PMID:22613834   PMID:22677168   PMID:22745667   PMID:22844345   PMID:22964333   PMID:22973453   PMID:22974441   PMID:23358419   PMID:23426619   PMID:23444376   PMID:23448571   PMID:23706161  
PMID:24086708   PMID:24284073   PMID:24287595   PMID:24470497   PMID:24658140   PMID:24728074   PMID:24769494   PMID:25056061   PMID:25137142   PMID:25218436   PMID:25241761   PMID:25321392  
PMID:25359136   PMID:25398386   PMID:25402006   PMID:25468996   PMID:25482634   PMID:25714462   PMID:25814554   PMID:26157164   PMID:26163016   PMID:26186194   PMID:26344197   PMID:26496610  
PMID:26554011   PMID:26590318   PMID:26638075   PMID:26760575   PMID:26871637   PMID:27033705   PMID:27432908   PMID:28455143   PMID:28455144   PMID:28514442   PMID:28675297   PMID:28954862  
PMID:29089450   PMID:29568061   PMID:29911835   PMID:29991678   PMID:30146921   PMID:30442385   PMID:31452512   PMID:31467278   PMID:31638742   PMID:31674657   PMID:31761329   PMID:31769754  
PMID:31980649   PMID:32203420   PMID:32296183   PMID:32427580   PMID:32446368   PMID:32468886   PMID:32739212  


Genomics

Comparative Map Data
NCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3136,862,208 - 136,951,606 (+)EnsemblGRCh38hg38GRCh38
GRCh383136,862,208 - 136,951,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373136,581,050 - 136,670,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,063,763 - 138,150,658 (+)NCBINCBI36hg18NCBI36
Build 343138,063,770 - 138,150,665NCBI
Celera3135,007,352 - 135,094,246 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3133,957,144 - 134,043,755 (+)NCBIHuRef
CHM1_13136,544,712 - 136,631,607 (+)NCBICHM1_1
Nck1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,376,047 - 100,428,187 (-)NCBIGRCm39mm39
GRCm39 Ensembl9100,374,346 - 100,428,187 (-)Ensembl
GRCm389100,494,302 - 100,546,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9100,492,293 - 100,546,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv379100,395,422 - 100,446,472 (-)NCBIGRCm37mm9NCBIm37
MGSCv369100,304,355 - 100,355,405 (-)NCBImm8
Celera9100,033,773 - 100,084,727 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
Nck1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28101,018,610 - 101,079,237 (-)NCBI
Rnor_6.0 Ensembl8108,787,798 - 108,847,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08108,787,797 - 108,847,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08108,204,372 - 108,264,127 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48105,346,933 - 105,409,843 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18105,365,785 - 105,380,767 (-)NCBI
Celera8100,416,045 - 100,476,576 (-)NCBICelera
Cytogenetic Map8q31NCBI
Nck1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555011,867,956 - 1,963,091 (-)NCBIChiLan1.0ChiLan1.0
NCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13141,362,407 - 141,451,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3141,427,870 - 141,451,444 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03133,902,463 - 133,990,414 (+)NCBIMhudiblu_PPA_v0panPan3
NCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12333,297,660 - 33,374,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2333,297,756 - 33,372,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2333,281,832 - 33,358,413 (+)NCBI
ROS_Cfam_1.02333,827,357 - 33,903,748 (+)NCBI
UMICH_Zoey_3.12333,509,571 - 33,586,142 (+)NCBI
UNSW_CanFamBas_1.02333,575,236 - 33,651,579 (+)NCBI
UU_Cfam_GSD_1.02333,819,866 - 33,896,593 (+)NCBI
Nck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560272,886,653 - 72,961,283 (+)NCBI
SpeTri2.0NW_0049365299,647,161 - 9,718,512 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,863,701 - 77,986,156 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11377,863,655 - 77,940,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21385,560,199 - 85,580,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11553,501,152 - 53,595,500 (-)NCBI
ChlSab1.1 Ensembl1553,500,623 - 53,523,576 (-)Ensembl
Vero_WHO_p1.0NW_02366604126,543,119 - 26,636,848 (-)NCBI
Nck1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473013,271,575 - 13,366,930 (+)NCBI

Position Markers
D3S3617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373136,601,263 - 136,601,454UniSTSGRCh37
Build 363138,083,953 - 138,084,144RGDNCBI36
Celera3135,027,549 - 135,027,740RGD
Cytogenetic Map3q21UniSTS
HuRef3133,977,036 - 133,977,227UniSTS
Marshfield Genetic Map3149.97RGD
Marshfield Genetic Map3149.97UniSTS
Genethon Genetic Map3151.5UniSTS
deCODE Assembly Map3144.06UniSTS
Whitehead-YAC Contig Map3 UniSTS
D3S3349  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373136,667,299 - 136,667,393UniSTSGRCh37
Build 363138,149,989 - 138,150,083RGDNCBI36
Celera3135,093,577 - 135,093,671RGD
Cytogenetic Map3q21UniSTS
HuRef3134,043,086 - 134,043,180UniSTS
GeneMap99-GB4 RH Map3491.07UniSTS
Whitehead-RH Map3632.5UniSTS
Whitehead-YAC Contig Map3 UniSTS
NCBI RH Map31200.8UniSTS
SHGC-77376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373136,667,113 - 136,667,324UniSTSGRCh37
Build 363138,149,803 - 138,150,014RGDNCBI36
Celera3135,093,391 - 135,093,602RGD
Cytogenetic Map3q21UniSTS
HuRef3134,042,900 - 134,043,111UniSTS
TNG Radiation Hybrid Map378400.0UniSTS
GeneMap99-GB4 RH Map3486.24UniSTS
NCBI RH Map31200.8UniSTS
D3S4077  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373136,579,575 - 136,579,700UniSTSGRCh37
Build 363138,062,265 - 138,062,390RGDNCBI36
Celera3135,005,877 - 135,006,002RGD
Cytogenetic Map3q21UniSTS
HuRef3133,955,669 - 133,955,794UniSTS
Whitehead-RH Map3624.9UniSTS
NCBI RH Map31200.8UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1991
Count of miRNA genes:841
Interacting mature miRNAs:972
Transcripts:ENST00000288986, ENST00000460960, ENST00000467911, ENST00000469404, ENST00000476286, ENST00000478862, ENST00000481752, ENST00000482071, ENST00000485096, ENST00000488930, ENST00000491539, ENST00000496489
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2080 1619 1425 393 1240 239 4076 1492 1515 267 1420 1601 169 1197 2519 3
Low 359 1372 301 231 710 226 281 705 2219 152 40 12 6 1 7 269 3 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP339594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA265476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA855124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB117533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000288986   ⟹   ENSP00000288986
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,208 - 136,949,126 (+)Ensembl
RefSeq Acc Id: ENST00000460960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,267 - 136,928,473 (+)Ensembl
RefSeq Acc Id: ENST00000467911   ⟹   ENSP00000418060
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,930,502 - 136,948,432 (+)Ensembl
RefSeq Acc Id: ENST00000469404   ⟹   ENSP00000419631
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,930,470 - 136,949,823 (+)Ensembl
RefSeq Acc Id: ENST00000476286   ⟹   ENSP00000418513
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,264 - 136,928,227 (+)Ensembl
RefSeq Acc Id: ENST00000478862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,267 - 136,928,724 (+)Ensembl
RefSeq Acc Id: ENST00000481752   ⟹   ENSP00000417273
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,208 - 136,951,606 (+)Ensembl
RefSeq Acc Id: ENST00000482071
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,945,725 - 136,947,047 (+)Ensembl
RefSeq Acc Id: ENST00000485096   ⟹   ENSP00000419677
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,242 - 136,945,702 (+)Ensembl
RefSeq Acc Id: ENST00000488930   ⟹   ENSP00000417729
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,298 - 136,946,218 (+)Ensembl
RefSeq Acc Id: ENST00000491539   ⟹   ENSP00000419302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,862,233 - 136,945,743 (+)Ensembl
RefSeq Acc Id: ENST00000496489   ⟹   ENSP00000419544
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3136,928,039 - 136,946,214 (+)Ensembl
RefSeq Acc Id: NM_001190796   ⟹   NP_001177725
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383136,930,502 - 136,951,606 (+)NCBI
GRCh373136,581,050 - 136,670,446 (+)NCBI
HuRef3133,957,144 - 134,043,755 (+)ENTREZGENE
CHM1_13136,612,954 - 136,634,091 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291999   ⟹   NP_001278928
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383136,862,208 - 136,951,606 (+)NCBI
CHM1_13136,544,712 - 136,634,091 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006153   ⟹   NP_006144
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383136,862,208 - 136,951,606 (+)NCBI
GRCh373136,581,050 - 136,670,446 (+)NCBI
Build 363138,063,763 - 138,150,658 (+)NCBI Archive
HuRef3133,957,144 - 134,043,755 (+)ENTREZGENE
CHM1_13136,544,712 - 136,634,091 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024453538   ⟹   XP_024309306
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383136,862,496 - 136,949,129 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006144   ⟸   NM_006153
- Peptide Label: isoform 1
- UniProtKB: P16333 (UniProtKB/Swiss-Prot),   A0A0S2Z4Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177725   ⟸   NM_001190796
- Peptide Label: isoform 2
- UniProtKB: P16333 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278928   ⟸   NM_001291999
- Peptide Label: isoform 1
- UniProtKB: P16333 (UniProtKB/Swiss-Prot),   A0A0S2Z4Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024309306   ⟸   XM_024453538
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000419302   ⟸   ENST00000491539
RefSeq Acc Id: ENSP00000418060   ⟸   ENST00000467911
RefSeq Acc Id: ENSP00000419631   ⟸   ENST00000469404
RefSeq Acc Id: ENSP00000417273   ⟸   ENST00000481752
RefSeq Acc Id: ENSP00000419544   ⟸   ENST00000496489
RefSeq Acc Id: ENSP00000419677   ⟸   ENST00000485096
RefSeq Acc Id: ENSP00000288986   ⟸   ENST00000288986
RefSeq Acc Id: ENSP00000417729   ⟸   ENST00000488930
RefSeq Acc Id: ENSP00000418513   ⟸   ENST00000476286
Protein Domains
SH2   SH3

Promoters
RGD ID:6865784
Promoter ID:EPDNEW_H6057
Type:initiation region
Name:NCK1_1
Description:NCK adaptor protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6055  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383136,862,233 - 136,862,293EPDNEW
RGD ID:6801332
Promoter ID:HG_KWN:46292
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006153
Position:
Human AssemblyChrPosition (strand)Source
Build 363138,063,541 - 138,064,187 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q22.1-23(chr3:132690641-141064444)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051570]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051570]|See cases [RCV000051570] Chr3:132690641..141064444 [GRCh38]
Chr3:132409485..140783286 [GRCh37]
Chr3:133892175..142265976 [NCBI36]
Chr3:3q22.1-23
pathogenic
GRCh38/hg38 3q22.1-22.3(chr3:132972567-136894498)x1 copy number loss See cases [RCV000051571] Chr3:132972567..136894498 [GRCh38]
Chr3:132691411..136613340 [GRCh37]
Chr3:134174101..138096030 [NCBI36]
Chr3:3q22.1-22.3
pathogenic
GRCh38/hg38 3q22.2-24(chr3:135227451-145870770)x1 copy number loss See cases [RCV000051572] Chr3:135227451..145870770 [GRCh38]
Chr3:134946293..145588557 [GRCh37]
Chr3:136428983..147071247 [NCBI36]
Chr3:3q22.2-24
pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q22.1-24(chr3:129817243-143381624)x1 copy number loss See cases [RCV000136558] Chr3:129817243..143381624 [GRCh38]
Chr3:129536086..143100466 [GRCh37]
Chr3:131018776..144583156 [NCBI36]
Chr3:3q22.1-24
pathogenic
GRCh38/hg38 3q22.2-25.1(chr3:134257180-149729538)x1 copy number loss See cases [RCV000138135] Chr3:134257180..149729538 [GRCh38]
Chr3:133976022..149447325 [GRCh37]
Chr3:135458712..150930015 [NCBI36]
Chr3:3q22.2-25.1
pathogenic|likely benign
GRCh38/hg38 3q22.1-23(chr3:130401265-139005019)x1 copy number loss See cases [RCV000139240] Chr3:130401265..139005019 [GRCh38]
Chr3:130120109..138723861 [GRCh37]
Chr3:131602799..140206551 [NCBI36]
Chr3:3q22.1-23
pathogenic
GRCh38/hg38 3q22.2-23(chr3:134333553-141701458)x1 copy number loss See cases [RCV000140453] Chr3:134333553..141701458 [GRCh38]
Chr3:134052395..141420300 [GRCh37]
Chr3:135535085..142902990 [NCBI36]
Chr3:3q22.2-23
pathogenic
GRCh38/hg38 3q22.1-23(chr3:129817243-141425155)x1 copy number loss See cases [RCV000140995] Chr3:129817243..141425155 [GRCh38]
Chr3:129536086..141143997 [GRCh37]
Chr3:131018776..142626687 [NCBI36]
Chr3:3q22.1-23
pathogenic
GRCh38/hg38 3q21.3-23(chr3:126106779-140918089)x3 copy number gain See cases [RCV000142010] Chr3:126106779..140918089 [GRCh38]
Chr3:125825622..140636931 [GRCh37]
Chr3:127308312..142119621 [NCBI36]
Chr3:3q21.3-23
uncertain significance
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24
pathogenic
GRCh38/hg38 3q22.1-24(chr3:132716978-144784743)x1 copy number loss See cases [RCV000143634] Chr3:132716978..144784743 [GRCh38]
Chr3:132435822..144503585 [GRCh37]
Chr3:133918512..145986275 [NCBI36]
Chr3:3q22.1-24
pathogenic
GRCh37/hg19 3q22.3-23(chr3:135935129-141867748)x3 copy number gain See cases [RCV000239877] Chr3:135935129..141867748 [GRCh37]
Chr3:3q22.3-23
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q22.3(chr3:135805001-137555312)x3 copy number gain not provided [RCV000682306] Chr3:135805001..137555312 [GRCh37]
Chr3:3q22.3
uncertain significance
GRCh38/hg38 3q22.2-22.3(chr3:135423479-136961152)x1 copy number loss Intellectual disability, autosomal dominant 47 [RCV000680252] Chr3:135423479..136961152 [GRCh38]
Chr3:135142319..136679992 [GRCh37]
Chr3:3q22.2-22.3
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q22.2-24(chr3:135288025-146874012) copy number gain not provided [RCV000767703] Chr3:135288025..146874012 [GRCh37]
Chr3:3q22.2-24
pathogenic
GRCh37/hg19 3q22.2-23(chr3:135186881-140826836)x3 copy number gain not provided [RCV000846949] Chr3:135186881..140826836 [GRCh37]
Chr3:3q22.2-23
uncertain significance
NM_001291999.2(NCK1):c.772G>C (p.Gly258Arg) single nucleotide variant not provided [RCV000956139] Chr3:136946128 [GRCh38]
Chr3:136664970 [GRCh37]
Chr3:3q22.3
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7664 AgrOrtholog
COSMIC NCK1 COSMIC
Ensembl Genes ENSG00000158092 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000288986 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417729 UniProtKB/TrEMBL
  ENSP00000418060 UniProtKB/TrEMBL
  ENSP00000418513 UniProtKB/TrEMBL
  ENSP00000419302 UniProtKB/TrEMBL
  ENSP00000419544 UniProtKB/TrEMBL
  ENSP00000419631 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000419677 UniProtKB/TrEMBL
Ensembl Transcript ENST00000288986 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000467911 UniProtKB/TrEMBL
  ENST00000469404 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000476286 UniProtKB/TrEMBL
  ENST00000481752 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000485096 UniProtKB/TrEMBL
  ENST00000488930 UniProtKB/TrEMBL
  ENST00000491539 UniProtKB/TrEMBL
  ENST00000496489 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000158092 GTEx
HGNC ID HGNC:7664 ENTREZGENE
Human Proteome Map NCK1 Human Proteome Map
InterPro EPS8 UniProtKB/TrEMBL
  EPS8-like UniProtKB/TrEMBL
  NCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4690 ENTREZGENE
OMIM 600508 OMIM
PANTHER PTHR12287 UniProtKB/TrEMBL
  PTHR12287:SF21 UniProtKB/TrEMBL
  PTHR19969:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31466 PharmGKB
PIRSF Cytoplasmic_NCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z4D7_HUMAN UniProtKB/TrEMBL
  A0A0S2Z4E4_HUMAN UniProtKB/TrEMBL
  A0A0S2Z4Y3 ENTREZGENE, UniProtKB/TrEMBL
  C9J0K5_HUMAN UniProtKB/TrEMBL
  C9J869_HUMAN UniProtKB/TrEMBL
  C9JAB9_HUMAN UniProtKB/TrEMBL
  C9JVV5_HUMAN UniProtKB/TrEMBL
  C9K098_HUMAN UniProtKB/TrEMBL
  H7C5C7_HUMAN UniProtKB/TrEMBL
  NCK1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B7Z751 UniProtKB/Swiss-Prot
  D3DNE3 UniProtKB/Swiss-Prot