EFNA5 (ephrin A5) - Rat Genome Database

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Gene: EFNA5 (ephrin A5) Homo sapiens
Analyze
Symbol: EFNA5
Name: ephrin A5
RGD ID: 1350398
HGNC Page HGNC
Description: Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; regulation of cytoskeleton organization; and regulation of focal adhesion assembly. Acts upstream of or within negative regulation of substrate adhesion-dependent cell spreading. Is anchored component of external side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AF1; AL-1; EFL5; eph-related receptor tyrosine kinase ligand 7; ephrin-A5; EPLG7; GLC1M; LERK-7; LERK7; RAGS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385107,376,894 - 107,670,937 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5107,376,894 - 107,670,937 (-)EnsemblGRCh38hg38GRCh38
GRCh375106,712,595 - 107,006,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365106,744,250 - 107,034,495 (-)NCBINCBI36hg18NCBI36
Build 345106,744,249 - 107,034,495NCBI
Celera5102,652,515 - 102,946,033 (-)NCBI
Cytogenetic Map5q21.3NCBI
HuRef5101,885,499 - 102,179,416 (-)NCBIHuRef
CHM1_15106,145,383 - 106,439,350 (-)NCBICHM1_1
T2T-CHM13v2.05107,879,857 - 108,173,778 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:7748564   PMID:8661153   PMID:8755474   PMID:9195962   PMID:9245480   PMID:9267020   PMID:9530499   PMID:9576626   PMID:9751130   PMID:10207129   PMID:10366629   PMID:10531456  
PMID:10601038   PMID:10730216   PMID:11128993   PMID:11256076   PMID:11416136   PMID:11519828   PMID:11870224   PMID:12477932   PMID:15107857   PMID:15489334   PMID:15777695   PMID:15901737  
PMID:17400922   PMID:17474147   PMID:17631495   PMID:18385452   PMID:18563700   PMID:18628988   PMID:19036963   PMID:19270726   PMID:19668339   PMID:19695673   PMID:19836338   PMID:20029409  
PMID:20228801   PMID:20379614   PMID:20505120   PMID:20659327   PMID:20889312   PMID:21873635   PMID:22072270   PMID:22074469   PMID:22568954   PMID:22623531   PMID:22860012   PMID:23242526  
PMID:23401654   PMID:23419831   PMID:23812375   PMID:23959867   PMID:25300504   PMID:25663355   PMID:25993310   PMID:26760575   PMID:27354374   PMID:28514442   PMID:28611215   PMID:30352868  
PMID:30561431   PMID:31988455   PMID:32296183   PMID:33389678   PMID:33893375   PMID:33961781  


Genomics

Comparative Map Data
EFNA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385107,376,894 - 107,670,937 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5107,376,894 - 107,670,937 (-)EnsemblGRCh38hg38GRCh38
GRCh375106,712,595 - 107,006,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365106,744,250 - 107,034,495 (-)NCBINCBI36hg18NCBI36
Build 345106,744,249 - 107,034,495NCBI
Celera5102,652,515 - 102,946,033 (-)NCBI
Cytogenetic Map5q21.3NCBI
HuRef5101,885,499 - 102,179,416 (-)NCBIHuRef
CHM1_15106,145,383 - 106,439,350 (-)NCBICHM1_1
T2T-CHM13v2.05107,879,857 - 108,173,778 (-)NCBI
Efna5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391762,909,952 - 63,188,312 (-)NCBIGRCm39mm39
GRCm39 Ensembl1762,911,179 - 63,188,312 (-)Ensembl
GRCm381762,602,957 - 62,881,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1762,604,184 - 62,881,317 (-)EnsemblGRCm38mm10GRCm38
MGSCv371762,952,306 - 63,230,666 (-)NCBIGRCm37mm9NCBIm37
MGSCv361762,290,210 - 62,566,779 (-)NCBImm8
Celera1766,941,186 - 67,218,870 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1732.57NCBI
Efna5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29102,316,753 - 102,595,480 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl9102,320,295 - 102,597,413 (-)Ensembl
Rnor_6.09110,054,002 - 110,329,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9110,057,155 - 110,225,486 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09109,624,143 - 109,898,215 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49101,227,615 - 101,532,696 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.19101,437,094 - 101,742,176 (-)NCBI
Celera999,743,743 - 100,016,279 (-)NCBICelera
Cytogenetic Map9q37NCBI
Efna5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554186,920,919 - 7,185,478 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554186,919,270 - 7,188,561 (+)NCBIChiLan1.0ChiLan1.0
EFNA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15108,548,927 - 108,842,729 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5108,548,927 - 108,598,942 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05102,732,268 - 103,026,746 (-)NCBIMhudiblu_PPA_v0panPan3
EFNA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.134,272,138 - 4,546,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl34,272,518 - 4,542,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha35,666,868 - 5,947,210 (+)NCBI
ROS_Cfam_1.034,163,164 - 4,443,229 (+)NCBI
ROS_Cfam_1.0 Ensembl34,169,390 - 4,439,740 (+)Ensembl
UMICH_Zoey_3.134,102,672 - 4,382,928 (+)NCBI
UNSW_CanFamBas_1.034,131,173 - 4,411,046 (+)NCBI
UU_Cfam_GSD_1.034,274,587 - 4,554,692 (+)NCBI
Efna5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213159,344,414 - 159,394,038 (+)NCBI
SpeTri2.0NW_0049365312,217,467 - 2,267,265 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFNA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2112,534,917 - 112,815,628 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12112,533,124 - 112,821,293 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22117,052,889 - 117,095,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EFNA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12310,823,243 - 11,115,175 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2310,823,261 - 10,873,666 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660363,139,584 - 3,432,471 (+)NCBIVero_WHO_p1.0
Efna5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474325,341,132 - 25,611,564 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474325,336,851 - 25,611,698 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D5S475  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,952,827 - 106,953,074UniSTSGRCh37
Build 365106,980,726 - 106,980,973RGDNCBI36
Celera5102,892,294 - 102,892,541RGD
Cytogenetic Map5q21UniSTS
HuRef5102,125,679 - 102,125,926UniSTS
Marshfield Genetic Map5114.75UniSTS
Marshfield Genetic Map5114.75RGD
Genethon Genetic Map5114.7UniSTS
TNG Radiation Hybrid Map547992.0UniSTS
deCODE Assembly Map5114.81UniSTS
GeneMap99-GB4 RH Map5457.95UniSTS
Whitehead-YAC Contig Map5 UniSTS
WI-18120  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,859,037 - 106,859,162UniSTSGRCh37
Build 365106,886,936 - 106,887,061RGDNCBI36
Celera5102,798,721 - 102,798,846RGD
Cytogenetic Map5q21UniSTS
HuRef5102,031,857 - 102,031,982UniSTS
GeneMap99-GB4 RH Map5455.92UniSTS
Whitehead-RH Map5358.4UniSTS
A006T32  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,713,638 - 106,713,784UniSTSGRCh37
Build 365106,741,537 - 106,741,683RGDNCBI36
Celera5102,653,563 - 102,653,709RGD
Cytogenetic Map5q21UniSTS
HuRef5101,886,547 - 101,886,693UniSTS
GeneMap99-GB4 RH Map5457.95UniSTS
RH16297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,714,375 - 106,714,510UniSTSGRCh37
Build 365106,742,274 - 106,742,409RGDNCBI36
Celera5102,654,300 - 102,654,435RGD
Cytogenetic Map5q21UniSTS
HuRef5101,887,284 - 101,887,419UniSTS
SHGC-82929  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,950,787 - 106,951,137UniSTSGRCh37
Build 365106,978,686 - 106,979,036RGDNCBI36
Celera5102,890,254 - 102,890,604RGD
Cytogenetic Map5q21UniSTS
HuRef5102,123,639 - 102,123,989UniSTS
TNG Radiation Hybrid Map547996.0UniSTS
D5S1688E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,713,564 - 106,713,703UniSTSGRCh37
Build 365106,741,463 - 106,741,602RGDNCBI36
Celera5102,653,489 - 102,653,628RGD
Cytogenetic Map5q21UniSTS
HuRef5101,886,473 - 101,886,612UniSTS
GDB:315565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,976,594 - 106,976,803UniSTSGRCh37
GRCh378144,112,990 - 144,114,398UniSTSGRCh37
Build 365107,004,493 - 107,004,702RGDNCBI36
Celera8140,422,825 - 140,424,233UniSTS
Celera5102,916,060 - 102,916,269RGD
Cytogenetic Map5q21UniSTS
HuRef5102,149,446 - 102,149,651UniSTS
HuRef8139,366,374 - 139,367,782UniSTS
SHGC-106401  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,749,877 - 106,750,190UniSTSGRCh37
Build 365106,777,776 - 106,778,089RGDNCBI36
Celera5102,689,503 - 102,689,816RGD
Cytogenetic Map5q21UniSTS
HuRef5101,922,694 - 101,923,007UniSTS
TNG Radiation Hybrid Map547876.0UniSTS
SHGC-142233  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,979,047 - 106,979,319UniSTSGRCh37
Build 365107,006,946 - 107,007,218RGDNCBI36
Celera5102,918,512 - 102,918,784RGD
Cytogenetic Map5q21UniSTS
HuRef5102,151,892 - 102,152,164UniSTS
TNG Radiation Hybrid Map548047.0UniSTS
SHGC-142620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,978,948 - 106,979,268UniSTSGRCh37
Build 365107,006,847 - 107,007,167RGDNCBI36
Celera5102,918,413 - 102,918,733RGD
Cytogenetic Map5q21UniSTS
HuRef5102,151,793 - 102,152,113UniSTS
TNG Radiation Hybrid Map548022.0UniSTS
SHGC-145540  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,928,948 - 106,929,274UniSTSGRCh37
Build 365106,956,847 - 106,957,173RGDNCBI36
Celera5102,868,415 - 102,868,741RGD
Cytogenetic Map5q21UniSTS
HuRef5102,101,801 - 102,102,127UniSTS
TNG Radiation Hybrid Map548007.0UniSTS
RH78310  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,716,462 - 106,716,607UniSTSGRCh37
Build 365106,744,361 - 106,744,506RGDNCBI36
Celera5102,656,384 - 102,656,529RGD
Cytogenetic Map5q21UniSTS
HuRef5101,889,370 - 101,889,515UniSTS
GeneMap99-GB4 RH Map5455.92UniSTS
SHGC-173148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,754,700 - 106,755,024UniSTSGRCh37
Build 365106,782,599 - 106,782,923RGDNCBI36
Celera5102,694,326 - 102,694,650RGD
Cytogenetic Map5q21UniSTS
TNG Radiation Hybrid Map547876.0UniSTS
EFNA5_1540  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,716,296 - 106,716,974UniSTSGRCh37
Build 365106,744,195 - 106,744,873RGDNCBI36
Celera5102,656,218 - 102,656,896RGD
HuRef5101,889,204 - 101,889,882UniSTS
SGC34450  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,714,511 - 106,714,660UniSTSGRCh37
Build 365106,742,410 - 106,742,559RGDNCBI36
Celera5102,654,436 - 102,654,585RGD
Cytogenetic Map5q21UniSTS
HuRef5101,887,420 - 101,887,569UniSTS
GeneMap99-GB4 RH Map5453.28UniSTS
Whitehead-RH Map5336.6UniSTS
RH12376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,858,292 - 106,858,508UniSTSGRCh37
Build 365106,886,191 - 106,886,407RGDNCBI36
Celera5102,797,976 - 102,798,192RGD
Cytogenetic Map5q21UniSTS
HuRef5102,031,112 - 102,031,328UniSTS
GeneMap99-GB4 RH Map5454.28UniSTS
RH36350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,820,180 - 106,820,298UniSTSGRCh37
Build 365106,848,079 - 106,848,197RGDNCBI36
Celera5102,759,836 - 102,759,954RGD
Cytogenetic Map5q21UniSTS
HuRef5101,992,976 - 101,993,094UniSTS
GeneMap99-GB4 RH Map5457.95UniSTS
WI-15986  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,712,639 - 106,712,739UniSTSGRCh37
Build 365106,740,538 - 106,740,638RGDNCBI36
Celera5102,652,564 - 102,652,664RGD
Cytogenetic Map5q21UniSTS
HuRef5101,885,548 - 101,885,648UniSTS
GeneMap99-GB4 RH Map5457.95UniSTS
Whitehead-RH Map5360.1UniSTS
D5S1443  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,979,866 - 106,980,166UniSTSGRCh37
Build 365107,007,765 - 107,008,065RGDNCBI36
Celera5102,919,331 - 102,919,631RGD
Cytogenetic Map5q21UniSTS
HuRef5102,152,711 - 102,153,011UniSTS
Stanford-G3 RH Map54275.0UniSTS
Whitehead-YAC Contig Map5 UniSTS
NCBI RH Map5712.8UniSTS
STS-D29229  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,812,561 - 106,812,712UniSTSGRCh37
Build 365106,840,460 - 106,840,611RGDNCBI36
Celera5102,752,233 - 102,752,384RGD
Cytogenetic Map5q21UniSTS
HuRef5101,985,358 - 101,985,509UniSTS
GeneMap99-GB4 RH Map5458.05UniSTS
A004F05  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,857,304 - 106,857,452UniSTSGRCh37
Build 365106,885,203 - 106,885,351RGDNCBI36
Celera5102,796,988 - 102,797,136RGD
Cytogenetic Map5q21UniSTS
HuRef5102,030,124 - 102,030,272UniSTS
GeneMap99-GB4 RH Map5455.43UniSTS
D5S1890  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,773,562 - 106,773,777UniSTSGRCh37
Build 365106,801,461 - 106,801,676RGDNCBI36
Celera5102,713,183 - 102,713,398RGD
Cytogenetic Map5q21UniSTS
HuRef5101,946,357 - 101,946,572UniSTS
Whitehead-YAC Contig Map5 UniSTS
EFNA5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,716,678 - 106,716,897UniSTSGRCh37
GRCh375106,716,880 - 106,717,077UniSTSGRCh37
Celera5102,656,600 - 102,656,819UniSTS
Celera5102,656,802 - 102,656,999UniSTS
HuRef5101,889,788 - 101,889,985UniSTS
HuRef5101,889,586 - 101,889,805UniSTS
EFNA5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375106,716,678 - 106,716,897UniSTSGRCh37
GRCh375106,716,880 - 106,717,077UniSTSGRCh37
Celera5102,656,600 - 102,656,819UniSTS
Celera5102,656,802 - 102,656,999UniSTS
HuRef5101,889,788 - 101,889,985UniSTS
HuRef5101,889,586 - 101,889,805UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2255
Count of miRNA genes:1032
Interacting mature miRNAs:1262
Transcripts:ENST00000333274, ENST00000504941, ENST00000505499, ENST00000509503, ENST00000510359
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 144 498 297 132 153 30 1768 37 486 155 420 205 110 201 916
Low 2243 1733 1002 164 836 107 2066 1586 3012 241 989 1372 61 1003 1352 4 1
Below cutoff 37 732 395 299 818 300 522 563 228 22 43 31 3 1 520

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC010227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC024587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U26403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000333274   ⟹   ENSP00000328777
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,376,894 - 107,670,937 (-)Ensembl
RefSeq Acc Id: ENST00000504941
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,426,976 - 107,670,885 (-)Ensembl
RefSeq Acc Id: ENST00000505499
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,427,217 - 107,506,191 (-)Ensembl
RefSeq Acc Id: ENST00000509503   ⟹   ENSP00000426989
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,381,238 - 107,670,627 (-)Ensembl
RefSeq Acc Id: ENST00000510359
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,380,984 - 107,388,553 (-)Ensembl
RefSeq Acc Id: ENST00000611503   ⟹   ENSP00000484681
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5107,376,889 - 107,427,514 (-)Ensembl
RefSeq Acc Id: NM_001962   ⟹   NP_001953
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385107,376,894 - 107,670,937 (-)NCBI
GRCh375106,712,590 - 107,006,596 (-)ENTREZGENE
Build 365106,744,250 - 107,034,495 (-)NCBI Archive
HuRef5101,885,499 - 102,179,416 (-)ENTREZGENE
CHM1_15106,145,383 - 106,439,350 (-)NCBI
T2T-CHM13v2.05107,879,857 - 108,173,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006714565   ⟹   XP_006714628
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385107,376,894 - 107,670,937 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543250   ⟹   XP_011541552
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385107,376,894 - 107,502,219 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001953   ⟸   NM_001962
- Peptide Label: precursor
- UniProtKB: P52803 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006714628   ⟸   XM_006714565
- Peptide Label: isoform X2
- UniProtKB: D6RDV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541552   ⟸   XM_011543250
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000328777   ⟸   ENST00000333274
RefSeq Acc Id: ENSP00000484681   ⟸   ENST00000611503
RefSeq Acc Id: ENSP00000426989   ⟸   ENST00000509503
Protein Domains
Ephrin RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52803-F1-model_v2 AlphaFold P52803 1-228 view protein structure

Promoters
RGD ID:6803023
Promoter ID:HG_KWN:50782
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:NM_001962,   UC010JBR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365107,034,061 - 107,035,237 (-)MPROMDB
RGD ID:6870210
Promoter ID:EPDNEW_H8270
Type:initiation region
Name:EFNA5_1
Description:ephrin A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385107,670,905 - 107,670,965EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1		 pathogenic
GRCh38/hg38 5q15-22.3(chr5:96454445-114050905)x3 copy number gain See cases [RCV000051841] Chr5:96454445..114050905 [GRCh38]
Chr5:95790149..113386602 [GRCh37]
Chr5:95815905..113414501 [NCBI36]
Chr5:5q15-22.3		 pathogenic
GRCh38/hg38 5q21.1-22.2(chr5:102373396-113594030)x1 copy number loss See cases [RCV000053523] Chr5:102373396..113594030 [GRCh38]
Chr5:101709100..112929727 [GRCh37]
Chr5:101736999..112957626 [NCBI36]
Chr5:5q21.1-22.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-23.1(chr5:107002209-118025316)x1 copy number loss See cases [RCV000135699] Chr5:107002209..118025316 [GRCh38]
Chr5:106337910..117361011 [GRCh37]
Chr5:106365809..117388910 [NCBI36]
Chr5:5q21.3-23.1		 pathogenic
GRCh38/hg38 5q21.3-22.1(chr5:106547519-110687501)x3 copy number gain See cases [RCV000138127] Chr5:106547519..110687501 [GRCh38]
Chr5:105883220..110023202 [GRCh37]
Chr5:105911119..110051101 [NCBI36]
Chr5:5q21.3-22.1		 likely pathogenic|uncertain significance
GRCh38/hg38 5q14.3-23.3(chr5:90374606-128076423)x1 copy number loss See cases [RCV000139893] Chr5:90374606..128076423 [GRCh38]
Chr5:89670423..127412115 [GRCh37]
Chr5:89706179..127440014 [NCBI36]
Chr5:5q14.3-23.3		 pathogenic
GRCh38/hg38 5q14.3-22.1(chr5:84603580-111435081)x1 copy number loss See cases [RCV000139656] Chr5:84603580..111435081 [GRCh38]
Chr5:83899398..110770779 [GRCh37]
Chr5:83935154..110798678 [NCBI36]
Chr5:5q14.3-22.1		 pathogenic
GRCh38/hg38 5q14.3-23.1(chr5:92899734-119614119)x1 copy number loss See cases [RCV000141252] Chr5:92899734..119614119 [GRCh38]
Chr5:92235441..118949814 [GRCh37]
Chr5:92261197..118977713 [NCBI36]
Chr5:5q14.3-23.1		 pathogenic
GRCh38/hg38 5q21.3-22.2(chr5:106586078-113006585)x1 copy number loss See cases [RCV000142171] Chr5:106586078..113006585 [GRCh38]
Chr5:105921779..112342282 [GRCh37]
Chr5:105949678..112370181 [NCBI36]
Chr5:5q21.3-22.2		 pathogenic
GRCh38/hg38 5q21.3(chr5:106619588-109258642)x3 copy number gain See cases [RCV000142807] Chr5:106619588..109258642 [GRCh38]
Chr5:105955289..108594343 [GRCh37]
Chr5:105983188..108622242 [NCBI36]
Chr5:5q21.3		 likely pathogenic
GRCh38/hg38 5q15-22.2(chr5:93193104-113287795)x1 copy number loss See cases [RCV000143249] Chr5:93193104..113287795 [GRCh38]
Chr5:92528810..112623492 [GRCh37]
Chr5:92554566..112651391 [NCBI36]
Chr5:5q15-22.2		 pathogenic
GRCh38/hg38 5q14.3-31.1(chr5:91411708-131319563)x1 copy number loss See cases [RCV000143746] Chr5:91411708..131319563 [GRCh38]
Chr5:90707525..130655256 [GRCh37]
Chr5:90743281..130683155 [NCBI36]
Chr5:5q14.3-31.1		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735)x1 copy number loss See cases [RCV000445968] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q21.3(chr5:105708752-108378522)x1 copy number loss See cases [RCV000510495] Chr5:105708752..108378522 [GRCh37]
Chr5:5q21.3		 uncertain significance
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5q21.3(chr5:106265124-107656892)x1 copy number loss not provided [RCV000682588] Chr5:106265124..107656892 [GRCh37]
Chr5:5q21.3		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q14.3-23.3(chr5:89949118-129317455)x3 copy number gain not provided [RCV000849289] Chr5:89949118..129317455 [GRCh37]
Chr5:5q14.3-23.3		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q21.3(chr5:105738092-108214791)x3 copy number gain not provided [RCV000846494] Chr5:105738092..108214791 [GRCh37]
Chr5:5q21.3		 uncertain significance
GRCh37/hg19 5q14.3-21.3(chr5:87792844-109221844)x3 copy number gain See cases [RCV001007415] Chr5:87792844..109221844 [GRCh37]
Chr5:5q14.3-21.3		 likely pathogenic
GRCh37/hg19 5q15-22.3(chr5:93650000-114969108) copy number loss not specified [RCV002053511] Chr5:93650000..114969108 [GRCh37]
Chr5:5q15-22.3		 pathogenic
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735) copy number loss not specified [RCV002053515] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3225 AgrOrtholog
COSMIC EFNA5 COSMIC
Ensembl Genes ENSG00000184349 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000328777 ENTREZGENE
  ENSP00000328777.6 UniProtKB/Swiss-Prot
  ENSP00000426989 ENTREZGENE
  ENSP00000426989.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000333274 ENTREZGENE
  ENST00000333274.11 UniProtKB/Swiss-Prot
  ENST00000509503 ENTREZGENE
  ENST00000509503.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000184349 GTEx
HGNC ID HGNC:3225 ENTREZGENE
Human Proteome Map EFNA5 Human Proteome Map
InterPro Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin-A_Ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1946 UniProtKB/Swiss-Prot
NCBI Gene 1946 ENTREZGENE
OMIM 601535 OMIM
PANTHER PTHR11304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27660 PharmGKB
PRINTS EPHRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EPHRIN_RBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN_RBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RDV5 ENTREZGENE, UniProtKB/TrEMBL
  EFNA5_HUMAN UniProtKB/Swiss-Prot
  L8E7B5_HUMAN UniProtKB/TrEMBL
  L8E8V0_HUMAN UniProtKB/TrEMBL
  P52803 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 EFNA5  ephrin A5    ephrin-A5  Symbol and/or name change 5135510 APPROVED
2011-08-17 EFNA5  ephrin-A5  EFNA5  ephrin-A5  Symbol and/or name change 5135510 APPROVED