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Gene: NRAS (NRAS proto-oncogene, GTPase) Homo sapiens
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Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
RGD ID: 735648
Description: Exhibits GTPase activity. Involved in Ras protein signal transduction and positive regulation of endothelial cell proliferation. Localizes to Golgi apparatus. Implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); epidermal nevus; and hematologic cancer (multiple). Biomarker of cervical cancer; cholangitis; liver carcinoma; prostate cancer; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS4; CMNS; GTPase NRas; N-ras; N-ras protein part 4; NCMS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS1; NS6; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Nras (neuroblastoma ras oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nras (NRAS proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nras (NRAS proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : NRAS (NRAS proto-oncogene, GTPase)
Canis lupus familiaris (dog) : NRAS (NRAS proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nras (NRAS proto-oncogene, GTPase)
Sus scrofa (pig) : NRAS (NRAS proto-oncogene, GTPase)
Chlorocebus sabaeus (African green monkey) : NRAS (NRAS proto-oncogene, GTPase)
Heterocephalus glaber (naked mole-rat) : Nras (NRAS proto-oncogene, GTPase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,247,085 - 115,259,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

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Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on NRAS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735648
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.