NRAS (NRAS proto-oncogene, GTPase) - Rat Genome Database

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Gene: NRAS (NRAS proto-oncogene, GTPase) Homo sapiens
Analyze
Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
RGD ID: 735648
HGNC Page HGNC
Description: Enables GTPase activity. Involved in Ras protein signal transduction and positive regulation of endothelial cell proliferation. Located in extracellular exosome and membrane. Part of Golgi apparatus. Implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); epidermal nevus; and hematologic cancer (multiple). Biomarker of cervical cancer; cholangitis; liver carcinoma; prostate cancer; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS4; CMNS; GTPase NRas; N-ras; N-ras protein part 4; NCMS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS1; NS6; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,247,090 - 115,259,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (IAGP)
acute myeloid leukemia  (EXP,IAGP,ISO)
acute promyelocytic leukemia  (EXP)
adrenocortical carcinoma  (IAGP)
adult hepatocellular carcinoma  (IAGP)
adult T-cell leukemia  (ISO)
anemia  (IAGP)
autoimmune lymphoproliferative syndrome  (EXP)
autoimmune lymphoproliferative syndrome type 4  (IAGP)
B-Cell Chronic Lymphocytic Leukemia  (IAGP)
B-cell lymphoma  (EXP)
bladder urothelial carcinoma  (IAGP)
Brain Neoplasms  (IAGP)
cervical cancer  (IEP)
cholangitis  (IEP)
chronic lymphocytic leukemia  (IAGP)
chronic myeloid leukemia  (IAGP)
chronic myelomonocytic leukemia  (ISO)
colon cancer  (IAGP)
colon carcinoma  (IAGP)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP,IAGP)
disease of cellular proliferation  (IAGP)
epidermal nevus  (IAGP)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Neoplasms  (IMP)
Experimental Neoplasms  (EXP)
Experimental Sarcoma  (ISO)
Follicular Thyroid Cancer  (EXP,IAGP)
gastric adenocarcinoma  (IAGP)
glioblastoma  (IAGP)
hepatocellular carcinoma  (IAGP,IGI)
juvenile myelomonocytic leukemia  (EXP,IAGP)
large congenital melanocytic nevus  (IAGP)
leukemia  (ISO)
Leukocytosis  (EXP)
linear nevus sebaceous syndrome  (IAGP)
liver carcinoma  (IEP)
Liver Metastasis  (IAGP)
lung adenocarcinoma  (IAGP)
lung non-small cell carcinoma  (IAGP)
lymphoma  (EXP)
medulloblastoma  (IAGP)
melanoma  (EXP,IAGP)
Mouth Neoplasms  (ISO)
multiple myeloma  (IAGP)
myelodysplastic syndrome  (IAGP)
myeloid leukemia associated with Down Syndrome  (EXP,IAGP)
myeloid neoplasm  (ISO)
Nasopharyngeal Neoplasms  (IAGP)
neuroblastoma  (EXP,IAGP)
Neurocutaneous Melanosis  (IAGP)
Neurodevelopmental Disorders  (IAGP)
neurofibrosarcoma  (EXP)
non-Hodgkin lymphoma  (IAGP)
Noonan syndrome  (EXP,IAGP)
Noonan syndrome 1  (IAGP)
Noonan syndrome 6  (IAGP)
ovarian serous cystadenocarcinoma  (IAGP)
papillary renal cell carcinoma  (IAGP)
Paraproteinemias  (IAGP)
Pigmented Nevus  (IAGP)
plasma cell neoplasm  (IAGP)
plasmacytoma  (IAGP)
prostate cancer  (IEP)
RASopathy  (IAGP)
rectal benign neoplasm  (EXP)
renal cell carcinoma  (IAGP)
Renal Cell Carcinoma 1  (IAGP)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (IAGP)
skin melanoma  (IAGP)
Splenomegaly  (EXP)
Stomach Neoplasms  (IAGP)
thyroid gland follicular carcinoma  (IAGP,IEA)
Thyroid Neoplasms  (IAGP)
transitional cell carcinoma  (IAGP,IEP)
uterine cancer  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-nitrotoluene  (ISO)
ammonium chloride  (ISO)
antimycin A  (EXP)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (ISO)
bromochloroacetic acid  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobimetinib  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
daunorubicin  (EXP)
Deguelin  (EXP)
deoxycholic acid  (EXP)
diclofenac  (EXP)
dicrotophos  (EXP)
disulfiram  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
genistein  (ISO)
glyphosate  (EXP)
hydroquinone  (EXP)
ivermectin  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
Matrine  (EXP)
metformin  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
microcystin-LR  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
ouabain  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
pemetrexed  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vemurafenib  (EXP)
vitamin E  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal bleeding  (IAGP)
Abnormal dermatoglyphics  (IAGP)
Abnormal hair quantity  (IAGP)
Abnormal leukocyte count  (IAGP)
Abnormal platelet function  (IAGP)
Abnormal pulmonary valve morphology  (IAGP)
Abnormality of coagulation  (IAGP)
Abnormality of dental color  (IAGP)
Abnormality of dental morphology  (IAGP)
Abnormality of finger  (IAGP)
Abnormality of the spleen  (IAGP)
Abnormality of toe  (IAGP)
Abnormality of vision  (IAGP)
Acute myeloid leukemia  (IAGP)
Adenoma sebaceum  (IAGP)
Adrenocortical carcinoma  (IAGP)
Alopecia  (IAGP)
Anemia  (IAGP)
Aplasia of the semicircular canal  (IAGP)
Aplasia/Hypoplasia of the abdominal wall musculature  (IAGP)
Aplasia/Hypoplasia of the corpus callosum  (IAGP)
Arachnoid cyst  (IAGP)
Arrhythmia  (IAGP)
Asymmetric growth  (IAGP)
Autoimmune thrombocytopenia  (IAGP)
Autosomal dominant inheritance  (IAGP)
Basal cell carcinoma  (IAGP)
Bilateral ptosis  (IAGP)
Biparietal narrowing  (IAGP)
Brachydactyly  (IAGP)
Brain neoplasm  (IAGP)
Broad forehead  (IAGP)
Broad nasal tip  (IAGP)
Cafe-au-lait spot  (IAGP)
Cavernous hemangioma  (IAGP)
Cerebral calcification  (IAGP)
Choroid plexus papilloma  (IAGP)
Chronic lymphatic leukemia  (IAGP)
Chronic myelogenous leukemia  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Coarctation of aorta  (IAGP)
Coarse hair  (IAGP)
Coloboma  (IAGP)
Colon cancer  (IAGP)
Congenital giant melanocytic nevus  (IAGP)
Congenital onset  (IAGP)
Corneal opacity  (IAGP)
Cranial asymmetry  (IAGP)
Cranial nerve paralysis  (IAGP)
Cryptorchidism  (IAGP)
Curly hair  (IAGP)
Cutaneous melanoma  (IAGP)
Cystic hygroma  (IAGP)
Dandy-Walker malformation  (IAGP)
Death in infancy  (IAGP)
Decreased lymphocyte apoptosis  (IAGP)
Deep philtrum  (IAGP)
Delayed skeletal maturation  (IAGP)
Delayed speech and language development  (IAGP)
Depressed nasal bridge  (IAGP)
Downslanted palpebral fissures  (IAGP)
Dysarthria  (IAGP)
Edema  (IAGP)
EEG abnormality  (IAGP)
Enlarged thorax  (IAGP)
Epicanthus  (IAGP)
Epidermal nevus  (IAGP)
Everted lower lip vermilion  (IAGP)
Facial asymmetry  (IAGP)
Feeding difficulties  (IAGP)
Feeding difficulties in infancy  (IAGP)
Follicular hyperplasia  (IAGP)
Follicular thyroid carcinoma  (IAGP)
Frontal bossing  (IAGP)
Full cheeks  (IAGP)
Generalized hirsutism  (IAGP)
Generalized hypotonia  (IAGP)
Genu recurvatum  (IAGP)
Glioblastoma multiforme  (IAGP)
Global developmental delay  (IAGP)
Growth delay  (IAGP)
Hemangioma  (IAGP)
Hemihypertrophy  (IAGP)
Hemimegalencephaly  (IAGP)
Hemolytic anemia  (IAGP)
Hepatocellular carcinoma  (IAGP)
Hepatomegaly  (IAGP)
Hereditary nonpolyposis colorectal carcinoma  (IAGP)
High forehead  (IAGP)
High palate  (IAGP)
Horseshoe kidney  (IAGP)
Hydrocephalus  (IAGP)
Hyperphosphaturia  (IAGP)
Hyperreflexia  (IAGP)
Hypertelorism  (IAGP)
Hypertrophic cardiomyopathy  (IAGP)
Hypogonadotropic hypogonadism  (IAGP)
Hypophosphatemic rickets  (IAGP)
Hypopigmentation of the skin  (IAGP)
Hypopigmented skin patches  (IAGP)
Hypotonia  (IAGP)
Ichthyosis  (IAGP)
Increased circulating antibody level  (IAGP)
Increased nuchal translucency  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, borderline  (IAGP)
Iris coloboma  (IAGP)
Irregular hyperpigmentation  (IAGP)
Joint hyperflexibility  (IAGP)
Juvenile myelomonocytic leukemia  (IAGP)
Keratosis pilaris  (IAGP)
Kyphoscoliosis  (IAGP)
Leukemia  (IAGP)
Linear nevus sebaceous  (IAGP)
Long eyebrows  (IAGP)
Long philtrum  (IAGP)
Low posterior hairline  (IAGP)
Low-set ears  (IAGP)
Low-set, posteriorly rotated ears  (IAGP)
Lung adenocarcinoma  (IAGP)
Lymphedema  (IAGP)
Lymphocytosis  (IAGP)
Lymphoma  (IAGP)
Lymphoproliferative disorder  (IAGP)
Macrocephaly  (IAGP)
Medulloblastoma  (IAGP)
Melanocytic nevus  (IAGP)
Melanoma  (IAGP)
Meningioma  (IAGP)
Mental deterioration  (IAGP)
Micrognathia  (IAGP)
Microphthalmia  (IAGP)
Midface retrusion  (IAGP)
Monocytosis  (IAGP)
Motor delay  (IAGP)
Multiple lentigines  (IAGP)
Multiple myeloma  (IAGP)
Muscle weakness  (IAGP)
Myelodysplasia  (IAGP)
Myopia  (IAGP)
Narrow nasal ridge  (IAGP)
Neoplasia of the nasopharynx  (IAGP)
Neoplasm  (IAGP)
Neoplasm of the large intestine  (IAGP)
Neoplasm of the stomach  (IAGP)
Neoplasm of the thyroid gland  (IAGP)
Neuroblastoma  (IAGP)
Neutropenia  (IAGP)
Nevus sebaceous  (IAGP)
Nevus spilus  (IAGP)
Non-Hodgkin lymphoma  (IAGP)
Non-medullary thyroid carcinoma  (IAGP)
Non-small cell lung carcinoma  (IAGP)
Numerous congenital melanocytic nevi  (IAGP)
Numerous nevi  (IAGP)
Nystagmus  (IAGP)
Open mouth  (IAGP)
Ophthalmoplegia  (IAGP)
Osteopenia  (IAGP)
Overgrowth  (IAGP)
Pancytopenia  (IAGP)
Papillary thyroid carcinoma  (IAGP)
Pectus carinatum  (IAGP)
Pectus excavatum  (IAGP)
Periorbital fullness  (IAGP)
Plagiocephaly  (IAGP)
Polyhydramnios  (IAGP)
Porencephalic cyst  (IAGP)
Precocious puberty  (IAGP)
Prominence of the premaxilla  (IAGP)
Prominent forehead  (IAGP)
Prominent occiput  (IAGP)
Proptosis  (IAGP)
Pruritus  (IAGP)
Ptosis  (IAGP)
Pulmonary artery stenosis  (IAGP)
Pulmonic stenosis  (IAGP)
Radioulnar synostosis  (IAGP)
Recurrent fractures  (IAGP)
Recurrent respiratory infections  (IAGP)
Reduced tendon reflexes  (IAGP)
Renal cell carcinoma  (IAGP)
Rhabdomyosarcoma  (IAGP)
Round face  (IAGP)
Scoliosis  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Short neck  (IAGP)
Short nose  (IAGP)
Short stature  (IAGP)
Single umbilical artery  (IAGP)
Somatic mosaicism  (IAGP)
Somatic mutation  (IAGP)
Sparse hair  (IAGP)
Splenomegaly  (IAGP)
Sporadic  (IAGP)
Strabismus  (IAGP)
Subcutaneous nodule  (IAGP)
Syringomyelia  (IAGP)
Telecanthus  (IAGP)
Thick lower lip vermilion  (IAGP)
Thickened helices  (IAGP)
Thickened nuchal skin fold  (IAGP)
Transitional cell carcinoma of the bladder  (IAGP)
Triangular face  (IAGP)
Uterine leiomyosarcoma  (IAGP)
Vertebral segmentation defect  (IAGP)
Webbed neck  (IAGP)
Wide intermamillary distance  (IAGP)
Wide nasal bridge  (IAGP)
References

References - curated
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2. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
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4. Chung SI, etal., Oncotarget. 2016 Feb 9;7(6):7354-66. doi: 10.18632/oncotarget.6931.
5. Dietrich P, etal., Neoplasia. 2019 Mar;21(3):257-268. doi: 10.1016/j.neo.2018.11.011. Epub 2019 Jan 25.
6. Dunna NR, etal., Indian J Biochem Biophys. 2014 Jun;51(3):207-10.
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8. GOA_HUMAN data from the GO Consortium
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16. Laragione T, etal., Arthritis Res Ther. 2008 Aug 15;10(4):R92.
17. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
18. Mulligan G, etal., Blood. 2014 Jan 30;123(5):632-9. doi: 10.1182/blood-2013-05-504340. Epub 2013 Dec 11.
19. Murphy DM, etal., Leukemia. 2013 Oct;27(10):2077-81. doi: 10.1038/leu.2013.160. Epub 2013 May 27.
20. Nakagawa R, etal., Hepatol Res. 2019 Jun;49(6):653-662. doi: 10.1111/hepr.13318. Epub 2019 Feb 26.
21. OMIM Disease Annotation Pipeline
22. Osaka M, etal., Mol Carcinog. 1997 Apr;18(4):206-12.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Pipeline to import SMPDB annotations from SMPDB into RGD
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
29. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
30. Traynor P, etal., Dis Markers. 2008;24(3):157-65.
31. Vairaktaris E, etal., In Vivo. 2007 Jul-Aug;21(4):615-21.
32. Walentinsson A and Levan G, Cancer Lett. 2001 May 10;166(1):47-53.
33. Wang J, etal., Blood. 2011 Jul 14;118(2):368-79. doi: 10.1182/blood-2010-12-326058. Epub 2011 May 17.
34. Zhang J, etal., J Biol Chem. 2015 Jul 31;290(31):19093-103. doi: 10.1074/jbc.M115.653154. Epub 2015 Jun 16.
Additional References at PubMed
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PMID:8665852   PMID:9069260   PMID:9069267   PMID:9269777   PMID:9297626   PMID:9344703   PMID:9368069   PMID:9488663   PMID:9578425   PMID:9674433   PMID:9690470   PMID:10412982  
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PMID:20619739   PMID:20628086   PMID:20678218   PMID:20680410   PMID:20703244   PMID:20713885   PMID:20720566   PMID:20726318   PMID:20736745   PMID:20815269   PMID:20824703   PMID:20860430  
PMID:20880116   PMID:20881644   PMID:20975100   PMID:21072204   PMID:21107323   PMID:21131919   PMID:21134978   PMID:21166657   PMID:21168197   PMID:21200020   PMID:21209378   PMID:21263000  
PMID:21305640   PMID:21358716   PMID:21430505   PMID:21478863   PMID:21595878   PMID:21615881   PMID:21750866   PMID:21757746   PMID:21788131   PMID:21796448   PMID:21809347   PMID:21873635  
PMID:21908617   PMID:21968647   PMID:21988832   PMID:22020736   PMID:22120021   PMID:22123847   PMID:22130161   PMID:22180178   PMID:22199277   PMID:22407852   PMID:22427190   PMID:22456166  
PMID:22589270   PMID:22614978   PMID:22650231   PMID:22753870   PMID:22758774   PMID:22773810   PMID:22809251   PMID:22820081   PMID:22887781   PMID:22912864   PMID:22926523   PMID:22931913  
PMID:22939629   PMID:22974165   PMID:22983396   PMID:22997201   PMID:23000456   PMID:23076151   PMID:23096702   PMID:23153525   PMID:23201159   PMID:23209302   PMID:23233531   PMID:23240926  
PMID:23262097   PMID:23303902   PMID:23313659   PMID:23362874   PMID:23376485   PMID:23392294   PMID:23403319   PMID:23423222   PMID:23448684   PMID:23477374   PMID:23496764   PMID:23515407  
PMID:23536553   PMID:23538902   PMID:23619365   PMID:23633454   PMID:23664541   PMID:23667841   PMID:23673558   PMID:23687087   PMID:23739925   PMID:23758196   PMID:23771122   PMID:23774633  
PMID:23782496   PMID:23795354   PMID:23821376   PMID:23833303   PMID:23855428   PMID:23860532   PMID:23861977   PMID:23922205   PMID:23987572   PMID:23993026   PMID:24006476   PMID:24006859  
PMID:24018645   PMID:24024839   PMID:24067137   PMID:24129063   PMID:24166518   PMID:24189344   PMID:24222113   PMID:24412244   PMID:24509877   PMID:24586049   PMID:24588908   PMID:24590757  
PMID:24603591   PMID:24610751   PMID:24666267   PMID:24691006   PMID:24703650   PMID:24710085   PMID:24714776   PMID:24737308   PMID:24758538   PMID:24774510   PMID:24798740   PMID:24802725  
PMID:24806288   PMID:24806883   PMID:24820091   PMID:24859998   PMID:24866436   PMID:24906137   PMID:24918823   PMID:24941944   PMID:24950457   PMID:24962318   PMID:25009008   PMID:25048604  
PMID:25063807   PMID:25105841   PMID:25109485   PMID:25150293   PMID:25157176   PMID:25158650   PMID:25164765   PMID:25227306   PMID:25252692   PMID:25263998   PMID:25316678   PMID:25316818  
PMID:25337237   PMID:25361812   PMID:25363723   PMID:25373533   PMID:25385688   PMID:25491172   PMID:25609649   PMID:25627962   PMID:25645078   PMID:25659223   PMID:25666295   PMID:25695684  
PMID:25722211   PMID:25736262   PMID:25749811   PMID:25767048   PMID:25796376   PMID:25815427   PMID:25851630   PMID:25858894   PMID:25886136   PMID:25896945   PMID:25901794   PMID:25914220  
PMID:25920435   PMID:25926041   PMID:25997687   PMID:25999051   PMID:25999467   PMID:26049686   PMID:26090869   PMID:26096079   PMID:26146664   PMID:26181424   PMID:26186194   PMID:26220150  
PMID:26222068   PMID:26225944   PMID:26253102   PMID:26260959   PMID:26272610   PMID:26282084   PMID:26297254   PMID:26305188   PMID:26318427   PMID:26325669   PMID:26393682   PMID:26399561  
PMID:26426340   PMID:26439863   PMID:26440707   PMID:26467218   PMID:26471487   PMID:26493479   PMID:26496610   PMID:26515069   PMID:26547216   PMID:26547258   PMID:26560143   PMID:26562020  
PMID:26562302   PMID:26575115   PMID:26581482   PMID:26597176   PMID:26691448   PMID:26701913   PMID:26799668   PMID:26807515   PMID:26862952   PMID:26947772   PMID:26973648   PMID:26980032  
PMID:26989027   PMID:27034005   PMID:27076591   PMID:27101548   PMID:27111337   PMID:27119512   PMID:27121310   PMID:27191502   PMID:27240832   PMID:27342126   PMID:27356691   PMID:27382031  
PMID:27385790   PMID:27391150   PMID:27433783   PMID:27449293   PMID:27458004   PMID:27488117   PMID:27502397   PMID:27502489   PMID:27556696   PMID:27630302   PMID:27634910   PMID:27636997  
PMID:27696542   PMID:27698462   PMID:27737491   PMID:27737711   PMID:27741509   PMID:27758885   PMID:27768959   PMID:27791198   PMID:27815357   PMID:27886225   PMID:27900779   PMID:27911734  
PMID:27916952   PMID:27936046   PMID:28025078   PMID:28074351   PMID:28091917   PMID:28097440   PMID:28098151   PMID:28100394   PMID:28116986   PMID:28134726   PMID:28162770   PMID:28192189  
PMID:28198367   PMID:28202657   PMID:28249840   PMID:28253523   PMID:28259994   PMID:28263956   PMID:28284557   PMID:28323937   PMID:28341702   PMID:28353383   PMID:28378457   PMID:28380455  
PMID:28426398   PMID:28446505   PMID:28514442   PMID:28551389   PMID:28594414   PMID:28630043   PMID:28646021   PMID:28668077   PMID:28680105   PMID:28703285   PMID:28714107   PMID:28797232  
PMID:28822769   PMID:28842324   PMID:28853218   PMID:28859058   PMID:28864536   PMID:28873354   PMID:28947418   PMID:29025887   PMID:29061376   PMID:29101736   PMID:29180316   PMID:29187493  
PMID:29194647   PMID:29198052   PMID:29275866   PMID:29280621   PMID:29329780   PMID:29332123   PMID:29335867   PMID:29397482   PMID:29495918   PMID:29509190   PMID:29564676   PMID:29665313  
PMID:29666387   PMID:29695835   PMID:29708356   PMID:29755118   PMID:29777862   PMID:29806051   PMID:29921458   PMID:29976257   PMID:30120967   PMID:30145692   PMID:30194290   PMID:30210039  
PMID:30359577   PMID:30361901   PMID:30384563   PMID:30384806   PMID:30442762   PMID:30442766   PMID:30484984   PMID:30489482   PMID:30518391   PMID:30542204   PMID:30548225   PMID:30562355  
PMID:30575818   PMID:30639242   PMID:30651601   PMID:30655611   PMID:30712867   PMID:30840064   PMID:30860980   PMID:30997501   PMID:31015455   PMID:31062740   PMID:31104677   PMID:31116161  
PMID:31162857   PMID:31228933   PMID:31337872   PMID:31350822   PMID:31442328   PMID:31511039   PMID:31527615   PMID:31549767   PMID:31586073   PMID:31630873   PMID:31638232   PMID:31647501  
PMID:31675434   PMID:31697451   PMID:31759987   PMID:31774543   PMID:31804006   PMID:31856410   PMID:31881025   PMID:31899815   PMID:31980649   PMID:32027256   PMID:32087194   PMID:32089414  
PMID:32171651   PMID:32227276   PMID:32296183   PMID:32393580   PMID:32562975   PMID:32587355   PMID:32620824   PMID:32628708   PMID:32699322   PMID:32706759   PMID:32732488   PMID:32743766  
PMID:32747568   PMID:32775409   PMID:32814053   PMID:32990852   PMID:33230298   PMID:33247684   PMID:33355187   PMID:33444485   PMID:33620658   PMID:33686722   PMID:33704722   PMID:33710503  
PMID:33773991   PMID:33956301   PMID:34006870   PMID:34230493  


Genomics

Comparative Map Data
NRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,247,090 - 115,259,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
Nras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,965,601 - 102,975,230 (+)NCBIGRCm39mm39
GRCm39 Ensembl3102,965,601 - 102,975,230 (+)Ensembl
GRCm383103,058,285 - 103,067,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,058,285 - 103,067,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,862,208 - 102,871,837 (+)NCBIGRCm37mm9NCBIm37
MGSCv363103,187,290 - 103,197,396 (+)NCBImm8
Celera3105,263,160 - 105,272,744 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Nras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22190,582,885 - 190,593,509 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)Ensembl
Rnor_6.02205,553,119 - 205,563,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,983,707 - 224,994,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,292,650 - 198,300,286 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12198,255,369 - 198,265,062 (+)NCBI
Celera2183,056,304 - 183,063,940 (+)NCBICelera
Cytogenetic Map2q34NCBI
Nras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,001,517 - 18,009,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,001,517 - 18,009,105 (-)NCBIChiLan1.0ChiLan1.0
NRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,890,505 - 122,903,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBIMhudiblu_PPA_v0panPan3
NRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,411,733 - 52,418,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,411,733 - 52,418,788 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,062,320 - 52,069,399 (-)NCBI
ROS_Cfam_1.01753,289,080 - 53,296,149 (-)NCBI
UMICH_Zoey_3.11752,323,232 - 52,330,285 (-)NCBI
UNSW_CanFamBas_1.01752,365,409 - 52,372,486 (-)NCBI
UU_Cfam_GSD_1.01752,938,741 - 52,945,813 (-)NCBI
Nras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,406,378 - 14,416,046 (+)NCBI
SpeTri2.0NW_00493662773,413 - 82,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,845,872 - 105,858,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,845,913 - 105,853,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,034,666 - 116,042,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,953,273 - 18,966,002 (+)NCBI
ChlSab1.1 Ensembl2018,953,883 - 18,961,931 (+)Ensembl
Vero_WHO_p1.0NW_02366603821,707,389 - 21,720,123 (+)NCBI
Nras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBI

Position Markers
RH17093  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37420,891,130 - 20,891,328UniSTSGRCh37
GRCh371115,247,168 - 115,247,366UniSTSGRCh37
Build 361115,048,691 - 115,048,889RGDNCBI36
Celera421,347,621 - 21,347,819UniSTS
Celera1113,476,425 - 113,476,623RGD
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map4p15.32UniSTS
HuRef420,239,814 - 20,240,012UniSTS
HuRef1113,105,642 - 113,105,840UniSTS
GDB:177368  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,256,467 - 115,256,569UniSTSGRCh37
Build 361115,057,990 - 115,058,092RGDNCBI36
Celera1113,485,709 - 113,485,811RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,114,926 - 113,115,028UniSTS
GDB:177539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,258,671 - 115,258,779UniSTSGRCh37
Build 361115,060,194 - 115,060,302RGDNCBI36
Celera1113,487,913 - 113,488,021RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,117,130 - 113,117,238UniSTS
GDB:178391  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,256,561 - 115,256,928UniSTSGRCh37
Build 361115,058,084 - 115,058,451RGDNCBI36
Celera1113,485,803 - 113,486,170RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,115,020 - 113,115,387UniSTS
G20630  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37420,891,130 - 20,891,328UniSTSGRCh37
GRCh371115,247,168 - 115,247,366UniSTSGRCh37
Build 361115,048,691 - 115,048,889RGDNCBI36
Celera421,347,621 - 21,347,819UniSTS
Celera1113,476,425 - 113,476,623RGD
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map4p15.32UniSTS
HuRef420,239,814 - 20,240,012UniSTS
HuRef1113,105,642 - 113,105,840UniSTS
PMC28413P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,258,677 - 115,258,791UniSTSGRCh37
Build 361115,060,200 - 115,060,314RGDNCBI36
Celera1113,487,919 - 113,488,033RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,117,136 - 113,117,250UniSTS
WI-17660  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,249,601 - 115,249,726UniSTSGRCh37
Build 361115,051,124 - 115,051,249RGDNCBI36
Celera1113,478,858 - 113,478,983RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,108,075 - 113,108,200UniSTS
GeneMap99-GB4 RH Map1371.76UniSTS
Whitehead-RH Map1433.8UniSTS
NCBI RH Map1789.8UniSTS
WI-21546  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,247,157 - 115,247,412UniSTSGRCh37
Build 361115,048,680 - 115,048,935RGDNCBI36
Celera1113,476,414 - 113,476,669RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,105,631 - 113,105,886UniSTS
GeneMap99-GB4 RH Map1371.65UniSTS
Whitehead-RH Map1429.9UniSTS
NCBI RH Map1788.3UniSTS
D1S3316  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,250,170 - 115,250,500UniSTSGRCh37
Build 361115,051,693 - 115,052,023RGDNCBI36
Celera1113,479,427 - 113,479,757RGD
Cytogenetic Map1p13.2UniSTS
HuRef1113,108,644 - 113,108,974UniSTS
GeneMap99-GB4 RH Map1372.04UniSTS
Whitehead-RH Map1423.7UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH64700  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,259,668 - 115,259,821UniSTSGRCh37
Build 361115,061,191 - 115,061,344RGDNCBI36
Celera1113,488,910 - 113,489,063RGD
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map1p22UniSTS
HuRef1113,118,127 - 113,118,280UniSTS
GeneMap99-GB4 RH Map1370.92UniSTS
NCBI RH Map1790.3UniSTS
SHGC-32741  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,259,580 - 115,259,688UniSTSGRCh37
Build 361115,061,103 - 115,061,211RGDNCBI36
Celera1113,488,822 - 113,488,930RGD
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map1p22UniSTS
HuRef1113,118,039 - 113,118,147UniSTS
TNG Radiation Hybrid Map162827.0UniSTS
GeneMap99-GB4 RH Map1370.75UniSTS
Whitehead-RH Map1427.0UniSTS
NCBI RH Map1788.3UniSTS
RH64875  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p13.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR20Ahsa-miR-20a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI19110058
MIR124-2hsa-miR-124-3pOncomiRDBexternal_infoNANA22558405
MIRLET7Chsa-let-7c-5pMirtarbaseexternal_infoMicroarray//Northern blot//qRT-PCR//Western blotFunctional MTI15766527
MIR145hsa-miR-145-5pOncomiRDBexternal_infoNANA23201159
MIR145hsa-miR-145-5pOncomiRDBexternal_infoNANA22592534
MIRLET7A2hsa-let-7a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19110058
MIRLET7A2hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI15766527
MIRLET7A1hsa-let-7a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19110058
MIRLET7A1hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI15766527

Predicted Target Of
Summary Value
Count of predictions:1309
Count of miRNA genes:811
Interacting mature miRNAs:919
Transcripts:ENST00000369535
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 1616 1007 1194 383 1346 267 3207 581 1943 352 1165 1588 133 1 1186 1646 6 1
Low 823 1983 532 241 604 198 1150 1616 1791 67 295 24 42 18 1142 1
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF493919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW021410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY428630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY941100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY941101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA007844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD032933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC094396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC094397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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Reference Sequences
RefSeq Acc Id: ENST00000369535   ⟹   ENSP00000358548
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)Ensembl
RefSeq Acc Id: NM_002524   ⟹   NP_002515
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,704,469 - 114,716,771 (-)NCBI
GRCh371115,247,085 - 115,259,515 (-)ENTREZGENE
Build 361115,051,108 - 115,061,038 (-)NCBI Archive
HuRef1113,105,559 - 113,117,974 (-)ENTREZGENE
CHM1_11115,361,892 - 115,374,317 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002515   ⟸   NM_002524
- UniProtKB: P01111 (UniProtKB/Swiss-Prot),   Q5U091 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000358548   ⟸   ENST00000369535

Promoters
RGD ID:6856714
Promoter ID:EPDNEW_H1522
Type:initiation region
Name:NRAS_1
Description:NRAS proto-oncogene, GTPase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,716,765 - 114,716,825EPDNEW
RGD ID:6786158
Promoter ID:HG_KWN:4244
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000406761,   NM_002524
Position:
Human AssemblyChrPosition (strand)Source
Build 361115,060,666 - 115,061,166 (-)MPROMDB
RGD ID:6850270
Promoter ID:EP30003
Type:multiple initiation site
Name:HS_NRAS
Description:Cellular-Neuroblastoma ras-like, NRAS gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 162; Mammalian N-ras gene
Tissues & Cell Lines:ubiquitous
Experiment Methods:Nuclease protection; Primer extension
Position:
Human AssemblyChrPosition (strand)Source
Build 361115,060,897 - 115,060,957EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002524.5(NRAS):c.464C>T (p.Ala155Val) single nucleotide variant not provided [RCV000521930] Chr1:114708641 [GRCh38]
Chr1:115251262 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.101C>T (p.Pro34Leu) single nucleotide variant Epidermal nevus [RCV000032848]|Noonan syndrome 1 [RCV000208568] Chr1:114716060 [GRCh38]
Chr1:115258681 [GRCh37]
Chr1:1p13.2
pathogenic|other
NM_002524.5(NRAS):c.38G>A (p.Gly13Asp) single nucleotide variant Acute megakaryoblastic leukemia in down syndrome [RCV001293767]|Acute myeloid leukemia [RCV000440357]|Adenocarcinoma of stomach [RCV000430350]|Juvenile myelomonocytic leukemia [RCV000014915]|Malignant melanoma of skin [RCV000422699]|Medulloblastoma [RCV000421906]|Melanoma [RCV000431020]|Multiple myeloma [RCV000433031]|Myelodysplastic syndrome [RCV000431528]|Neoplasm of the large intestine [RCV000440593]|Non-Hodgkin lymphoma [RCV000442419]|Noonan syndrome 6 [RCV000022690]|RAS-associated autoimmune leukoproliferative disorder [RCV000144962]|Transitional cell carcinoma of the bladder [RCV000421229]|not provided [RCV000157672] Chr1:114716123 [GRCh38]
Chr1:115258744 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.149C>T (p.Thr50Ile) single nucleotide variant Noonan syndrome 1 [RCV000208537]|Noonan syndrome 6 [RCV000014916]|Noonan syndrome [RCV000211835]|Rasopathy [RCV000463185] Chr1:114713941 [GRCh38]
Chr1:115256562 [GRCh37]
Chr1:1p13.2
pathogenic
NM_002524.5(NRAS):c.179G>A (p.Gly60Glu) single nucleotide variant Noonan syndrome 1 [RCV000208552]|Noonan syndrome 6 [RCV000014917]|Rasopathy [RCV001382056]|not provided [RCV000158982] Chr1:114713911 [GRCh38]
Chr1:115256532 [GRCh37]
Chr1:1p13.2
pathogenic
NM_002524.5(NRAS):c.25G>A (p.Val9Ile) single nucleotide variant Rasopathy [RCV000545519] Chr1:114716136 [GRCh38]
Chr1:115258757 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.37G>C (p.Gly13Arg) single nucleotide variant Acute myeloid leukemia [RCV000438070]|Adenocarcinoma of stomach [RCV000427817]|Carcinoma of colon [RCV000014913]|Large congenital melanocytic nevus [RCV000114743]|Malignant melanoma of skin [RCV000444449]|Medulloblastoma [RCV000419545]|Melanoma [RCV000424942]|Multiple myeloma [RCV000426328]|Myelodysplastic syndrome [RCV000428963]|Neoplasm of the large intestine [RCV000434327]|Non-Hodgkin lymphoma [RCV000437450]|Transitional cell carcinoma of the bladder [RCV000419583] Chr1:114716124 [GRCh38]
Chr1:115258745 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic|other
NM_002524.5(NRAS):c.182A>G (p.Gln61Arg) single nucleotide variant Acute myeloid leukemia [RCV000441317]|Adenocarcinoma of stomach [RCV000439264]|Adrenocortical carcinoma [RCV000422078]|Chronic lymphocytic leukemia [RCV000420832]|Epidermal nevus [RCV000032847]|Epidermal nevus syndrome [RCV000148032]|Glioblastoma [RCV000438052]|Hepatocellular carcinoma [RCV000432961]|Large congenital melanocytic nevus [RCV000114744]|Lung adenocarcinoma [RCV000424721]|Malignant melanoma of skin [RCV000430407]|Malignant neoplasm of body of uterus [RCV000445249]|Melanoma [RCV000424960]|Multiple myeloma [RCV000431883]|Nasopharyngeal Neoplasms [RCV000430593]|Neoplasm of brain [RCV000424455]|Neoplasm of the large intestine [RCV000435687]|Neurocutaneous melanocytosis [RCV000114745]|Non-small cell lung cancer [RCV000037574]|Ovarian Serous Cystadenocarcinoma [RCV000422278]|Renal cell carcinoma, papillary, 1 [RCV000419710]|Thyroid cancer, nonmedullary, 2 [RCV000014914]|Transitional cell carcinoma of the bladder [RCV000440367]|not provided [RCV000413804] Chr1:114713908 [GRCh38]
Chr1:115256529 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic|other|not provided
NRAS:c.181C>A (p.Gln61Lys) single nucleotide variant MELANOCYTIC NEVUS SYNDROME, CONGENITAL, SOMATIC [RCV000114746]|NEUROCUTANEOUS MELANOSIS, SOMATIC INCLUDED [RCV000114747] Chr1:114713909 [GRCh38]
Chr1:115256530 [GRCh37]
Chr1:1p13.2
other
NM_002524.5(NRAS):c.35G>A (p.Gly12Asp) single nucleotide variant Acute myeloid leukemia [RCV000436228]|Adenocarcinoma of stomach [RCV000434517]|Epidermal nevus [RCV000032849]|Juvenile myelomonocytic leukemia [RCV000144963]|Malignant melanoma of skin [RCV000440963]|Malignant neoplasm of body of uterus [RCV000430706]|Melanoma [RCV000417869]|Multiple myeloma [RCV000417702]|Myelodysplastic syndrome [RCV000424239]|Neoplasm of the large intestine [RCV000427949]|Non-small cell lung cancer [RCV000439064]|not provided [RCV000158980] Chr1:114716126 [GRCh38]
Chr1:115258747 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic|other|not provided
NM_002524.5(NRAS):c.291-8G>A single nucleotide variant Rasopathy [RCV000862599]|not specified [RCV000037575] Chr1:114709736 [GRCh38]
Chr1:115252357 [GRCh37]
Chr1:1p13.2
likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_002524.5(NRAS):c.35G>T (p.Gly12Val) single nucleotide variant Acute myeloid leukemia [RCV000429393]|Adenocarcinoma of stomach [RCV000423890]|Malignant melanoma of skin [RCV000438750]|Malignant neoplasm of body of uterus [RCV000438967]|Melanoma [RCV000419124]|Multiple myeloma [RCV000421072]|Myelodysplastic syndrome [RCV000432178]|Neoplasm of the large intestine [RCV000439421]|Noonan syndrome [RCV000037576]|Rasopathy [RCV001377735]|not provided [RCV000158986] Chr1:114716126 [GRCh38]
Chr1:115258747 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.360G>A (p.Leu120=) single nucleotide variant Noonan syndrome 6 [RCV001100796]|Rasopathy [RCV001080827]|not provided [RCV000587570]|not specified [RCV000037577] Chr1:114709659 [GRCh38]
Chr1:115252280 [GRCh37]
Chr1:1p13.2
benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
GRCh38/hg38 1p13.3-12(chr1:109756630-118650204)x3 copy number gain See cases [RCV000051827] Chr1:109756630..118650204 [GRCh38]
Chr1:110299252..119192827 [GRCh37]
Chr1:110100775..118994350 [NCBI36]
Chr1:1p13.3-12
pathogenic
NM_002524.5(NRAS):c.181C>A (p.Gln61Lys) single nucleotide variant Acute myeloid leukemia [RCV000418907]|Adenocarcinoma of stomach [RCV000441348]|Adrenocortical carcinoma [RCV000431313]|Chronic lymphocytic leukemia [RCV000418269]|Glioblastoma [RCV000428264]|Hepatocellular carcinoma [RCV000441559]|Large congenital melanocytic nevus [RCV000114746]|Lung adenocarcinoma [RCV000433274]|Malignant melanoma of skin [RCV000436806]|Malignant neoplasm of body of uterus [RCV000436588]|Melanoma [RCV000434388]|Multiple myeloma [RCV000444882]|Nasopharyngeal Neoplasms [RCV000426976]|Neoplasm of brain [RCV000435041]|Neoplasm of the large intestine [RCV000444538]|Neuroblastoma [RCV000423656]|Neurocutaneous melanocytosis [RCV000144964]|Non-small cell lung cancer [RCV000425440]|Ovarian Serous Cystadenocarcinoma [RCV000443974]|Ras Inhibitor response [RCV000626456]|Rasopathy [RCV000696329]|Renal cell carcinoma, papillary, 1 [RCV000423012]|Transitional cell carcinoma of the bladder [RCV000428499]|Vascular Tumors Including Pyogenic Granuloma [RCV000662267]|not provided [RCV001092890] Chr1:114713909 [GRCh38]
Chr1:115256530 [GRCh37]
Chr1:115058053 [NCBI36]
Chr1:1p13.2
pathogenic|likely pathogenic|drug response|uncertain significance|other|not provided
NM_002524.5(NRAS):c.504G>C (p.Met168Ile) single nucleotide variant not provided [RCV000680367]|not specified [RCV000121741] Chr1:114708601 [GRCh38]
Chr1:115251222 [GRCh37]
Chr1:1p13.2
uncertain significance|not provided
NM_002524.5(NRAS):c.112-8A>G single nucleotide variant Noonan syndrome 6 [RCV001101050]|Rasopathy [RCV001089307]|not provided [RCV000588495]|not specified [RCV000127228] Chr1:114713986 [GRCh38]
Chr1:115256607 [GRCh37]
Chr1:1p13.2
benign|likely benign|uncertain significance
NM_002524.5(NRAS):c.-50A>G single nucleotide variant Noonan syndrome 6 [RCV000377346]|not specified [RCV000127229] Chr1:114716690 [GRCh38]
Chr1:115259311 [GRCh37]
Chr1:1p13.2
benign|likely benign|uncertain significance
NM_002524.5(NRAS):c.503T>A (p.Met168Lys) single nucleotide variant not specified [RCV001293540] Chr1:114708602 [GRCh38]
Chr1:115251223 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh38/hg38 1p13.2(chr1:114499327-114926423)x1 copy number loss See cases [RCV000139157] Chr1:114499327..114926423 [GRCh38]
Chr1:115041949..115469044 [GRCh37]
Chr1:114843472..115270567 [NCBI36]
Chr1:1p13.2
uncertain significance
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12
pathogenic
NM_002524.5(NRAS):c.553C>T (p.Pro185Ser) single nucleotide variant Noonan syndrome 6 [RCV000373742]|Noonan syndrome [RCV001261093]|Rasopathy [RCV000654962]|not specified [RCV000155806] Chr1:114708552 [GRCh38]
Chr1:115251173 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002524.5(NRAS):c.34G>A (p.Gly12Ser) single nucleotide variant Acute myeloid leukemia [RCV000445150]|Adenocarcinoma of stomach [RCV000442594]|Juvenile myelomonocytic leukemia [RCV000158978]|Malignant melanoma of skin [RCV000421993]|Malignant neoplasm of body of uterus [RCV000427184]|Melanoma [RCV000431995]|Multiple myeloma [RCV000433097]|Myelodysplastic syndrome [RCV000430288]|Neoplasm of the large intestine [RCV000439216]|Non-small cell lung cancer [RCV000421327]|Rasopathy [RCV001066799]|not provided [RCV000212761] Chr1:114716127 [GRCh38]
Chr1:115258748 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.368G>A (p.Arg123Lys) single nucleotide variant not specified [RCV000151575] Chr1:114709651 [GRCh38]
Chr1:115252272 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.225C>T (p.Gly75=) single nucleotide variant Noonan syndrome 6 [RCV000320449]|Rasopathy [RCV001086742]|not provided [RCV000157673]|not specified [RCV000154799] Chr1:114713865 [GRCh38]
Chr1:115256486 [GRCh37]
Chr1:1p13.2
benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_002524.5(NRAS):c.159G>A (p.Leu53=) single nucleotide variant Rasopathy [RCV000534894]|not specified [RCV000151574] Chr1:114713931 [GRCh38]
Chr1:115256552 [GRCh37]
Chr1:1p13.2
benign|likely benign
NM_002524.5(NRAS):c.34G>T (p.Gly12Cys) single nucleotide variant Acute myeloid leukemia [RCV000433830]|Adenocarcinoma of stomach [RCV000432311]|Malignant melanoma of skin [RCV000435186]|Malignant neoplasm of body of uterus [RCV000422059]|Melanoma [RCV000444830]|Multiple myeloma [RCV000425805]|Myelodysplastic syndrome [RCV000445013]|Neoplasm of the large intestine [RCV000422738]|Non-small cell lung cancer [RCV000440380]|not provided [RCV000158979] Chr1:114716127 [GRCh38]
Chr1:115258748 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.34G>C (p.Gly12Arg) single nucleotide variant Acute myeloid leukemia [RCV000423088]|Adenocarcinoma of stomach [RCV000420637]|Chronic myelogenous leukemia, BCR-ABL1 positive [RCV000430635]|Increased nuchal translucency [RCV001526619]|Malignant melanoma of skin [RCV000430032]|Malignant neoplasm of body of uterus [RCV000438291]|Melanoma [RCV000444217]|Multiple myeloma [RCV000420396]|Myelodysplastic syndrome [RCV000440262]|Neoplasm of the large intestine [RCV000435447]|Non-small cell lung cancer [RCV000425150]|not provided [RCV000158985] Chr1:114716127 [GRCh38]
Chr1:115258748 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.562G>A (p.Val188Met) single nucleotide variant not provided [RCV000157674] Chr1:114708543 [GRCh38]
Chr1:115251164 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.175G>A (p.Ala59Thr) single nucleotide variant not provided [RCV000158981] Chr1:114713915 [GRCh38]
Chr1:115256536 [GRCh37]
Chr1:1p13.2
likely pathogenic
NM_002524.5(NRAS):c.325G>C (p.Val109Leu) single nucleotide variant not provided [RCV000158983] Chr1:114709694 [GRCh38]
Chr1:115252315 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.112-1_113dup duplication Rasopathy [RCV000158984] Chr1:114713976..114713977 [GRCh38]
Chr1:115256597..115256598 [GRCh37]
Chr1:1p13.2
pathogenic
NM_002524.5(NRAS):c.334G>T (p.Val112Leu) single nucleotide variant not provided [RCV000158987] Chr1:114709685 [GRCh38]
Chr1:115252306 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.442A>G (p.Thr148Ala) single nucleotide variant not provided [RCV000158988] Chr1:114709577 [GRCh38]
Chr1:115252198 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*344A>G single nucleotide variant Noonan syndrome 6 [RCV000259443] Chr1:114707750 [GRCh38]
Chr1:115250371 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.317C>T (p.Ser106Leu) single nucleotide variant Noonan syndrome 6 [RCV000709916]|not specified [RCV000194018] Chr1:114709702 [GRCh38]
Chr1:115252323 [GRCh37]
Chr1:1p13.2
uncertain significance|not provided
NM_002524.5(NRAS):c.*1643G>C single nucleotide variant Noonan syndrome 6 [RCV000285060] Chr1:114706451 [GRCh38]
Chr1:115249072 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.380C>G (p.Thr127Arg) single nucleotide variant Noonan syndrome 6 [RCV000262996] Chr1:114709639 [GRCh38]
Chr1:115252260 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.182A>C (p.Gln61Pro) single nucleotide variant Acute myeloid leukemia [RCV000444278]|Adenocarcinoma of stomach [RCV000421291]|Adrenocortical carcinoma [RCV000419053]|Chronic lymphocytic leukemia [RCV000420302]|Glioblastoma [RCV000432170]|Hepatocellular carcinoma [RCV000437545]|Lung adenocarcinoma [RCV000439765]|Malignant melanoma of skin [RCV000427746]|Malignant neoplasm of body of uterus [RCV000421496]|Melanoma [RCV000431592]|Multiple myeloma [RCV000419201]|Nasopharyngeal Neoplasms [RCV000426654]|Neoplasm of brain [RCV000434604]|Neoplasm of the large intestine [RCV000430000]|Neoplasm of the thyroid gland [RCV000438468]|Non-small cell lung cancer [RCV000428903]|Ovarian Serous Cystadenocarcinoma [RCV000439526]|Renal cell carcinoma, papillary, 1 [RCV000444660]|Transitional cell carcinoma of the bladder [RCV000437312]|not provided [RCV000291285] Chr1:114713908 [GRCh38]
Chr1:115256529 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic
NM_002524.5(NRAS):c.35G>C (p.Gly12Ala) single nucleotide variant Acute myeloid leukemia [RCV000426950]|Adenocarcinoma of stomach [RCV000433455]|Malignant melanoma of skin [RCV000444591]|Malignant neoplasm of body of uterus [RCV000437165]|Melanoma [RCV000434113]|Multiple myeloma [RCV000418647]|Myelodysplastic syndrome [RCV000425963]|Myelodysplastic syndrome progressed to acute myeloid leukemia [RCV000203450]|Neoplasm of the large intestine [RCV000444670]|Non-small cell lung cancer [RCV000427550]|Rasopathy [RCV001324275]|not provided [RCV000380895] Chr1:114716126 [GRCh38]
Chr1:115258747 [GRCh37]
Chr1:1p13.2
pathogenic|likely pathogenic|uncertain significance
NM_002524.5(NRAS):c.71T>A (p.Ile24Asn) single nucleotide variant Noonan syndrome 1 [RCV000208553]|not provided [RCV000522652] Chr1:114716090 [GRCh38]
Chr1:115258711 [GRCh37]
Chr1:1p13.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
NM_002524.5(NRAS):c.461A>G (p.Asp154Gly) single nucleotide variant Rasopathy [RCV000548898] Chr1:114708644 [GRCh38]
Chr1:115251265 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.290+15A>C single nucleotide variant not specified [RCV000600398] Chr1:114713785 [GRCh38]
Chr1:115256406 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*3366G>T single nucleotide variant Noonan syndrome 6 [RCV000278492] Chr1:114704728 [GRCh38]
Chr1:115247349 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.-106G>T single nucleotide variant Noonan syndrome 6 [RCV000285468] Chr1:114716746 [GRCh38]
Chr1:115259367 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*2327C>T single nucleotide variant Noonan syndrome 6 [RCV000281427] Chr1:114705767 [GRCh38]
Chr1:115248388 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002524.5(NRAS):c.*2662G>A single nucleotide variant Noonan syndrome 6 [RCV000272399] Chr1:114705432 [GRCh38]
Chr1:115248053 [GRCh37]
Chr1:1p13.2
benign|likely benign
NM_002524.5(NRAS):c.*2510_*2515del deletion Noonan syndrome [RCV000277907] Chr1:114705579..114705584 [GRCh38]
Chr1:115248200..115248205 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*2464A>G single nucleotide variant Noonan syndrome 6 [RCV000373515] Chr1:114705630 [GRCh38]
Chr1:115248251 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002524.5(NRAS):c.*2844T>A single nucleotide variant Noonan syndrome 6 [RCV000398306] Chr1:114705250 [GRCh38]
Chr1:115247871 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*2965del deletion Noonan syndrome [RCV000300681] Chr1:114705129 [GRCh38]
Chr1:115247750 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*2513T>A single nucleotide variant Noonan syndrome 6 [RCV000316496] Chr1:114705581 [GRCh38]
Chr1:115248202 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*3219C>G single nucleotide variant Noonan syndrome 6 [RCV000335852] Chr1:114704875 [GRCh38]
Chr1:115247496 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*111A>G single nucleotide variant Noonan syndrome 6 [RCV000317051] Chr1:114707983 [GRCh38]
Chr1:115250604 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.4(NRAS):c.-208T>A single nucleotide variant Noonan syndrome [RCV000288966] Chr1:114716848 [GRCh38]
Chr1:115259469 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*2805T>C single nucleotide variant Noonan syndrome 6 [RCV000304039] Chr1:114705289 [GRCh38]
Chr1:115247910 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*3384C>T single nucleotide variant Noonan syndrome 6 [RCV000405052] Chr1:114704710 [GRCh38]
Chr1:115247331 [GRCh37]
Chr1:1p13.2
benign|likely benign
NM_002524.5(NRAS):c.*2784T>A single nucleotide variant Noonan syndrome 6 [RCV000361225] Chr1:114705310 [GRCh38]
Chr1:115247931 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002524.5(NRAS):c.*3404T>C single nucleotide variant Noonan syndrome 6 [RCV000292737] Chr1:114704690 [GRCh38]
Chr1:115247311 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*2667T>C single nucleotide variant Noonan syndrome 6 [RCV000364455] Chr1:114705427 [GRCh38]
Chr1:115248048 [GRCh37]
Chr1:1p13.2
benign|likely benign
NM_002524.5(NRAS):c.*3499C>T single nucleotide variant Noonan syndrome 6 [RCV000386944] Chr1:114704595 [GRCh38]
Chr1:115247216 [GRCh37]
Chr1:1p13.2
likely benign
NM_002524.5(NRAS):c.*2546C>T single nucleotide variant Noonan syndrome 6 [RCV000388618] Chr1:114705548 [GRCh38]
Chr1:115248169 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002524.5(NRAS):c.*872C>T single nucleotide variant Noonan syndrome 6 [RCV000345781] Chr1:114707222 [GRCh38]
Chr1:115249843 [GRCh37]
Chr1:1p13.2
benign|likely benign
NM_002524.5(NRAS):c.*583T>G single nucleotide variant Noonan syndrome 6 [RCV000367629] Chr1:114707511 [GRCh38]
Chr1:115250132 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance