RGD Reference Report - An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. - Rat Genome Database

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An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients.

Authors: Traynor, P  McGlynn, LM  Mukhergee, R  Grimsley, SJ  Bartlett, JM  Edwards, J 
Citation: Traynor P, etal., Dis Markers. 2008;24(3):157-65.
RGD ID: 2314837
Pubmed: PMID:18334737   (View Abstract at PubMed)
PMCID: PMC3850597   (View Article at PubMed Central)

Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse (p=0.01) and shorter disease specific survival (p=0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p=0.02) and expression correlated with phosphorylated MAP kinase (p=0.010) and proliferation index (Ki67, p=0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer disease_progressionIEP 2314837 RGD 
prostate cancer disease_progressionISONRAS (Homo sapiens)2314837; 2314837 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nras  (NRAS proto-oncogene, GTPase)

Genes (Mus musculus)
Nras  (neuroblastoma ras oncogene)

Genes (Homo sapiens)
NRAS  (NRAS proto-oncogene, GTPase)


Additional Information