NRAS (NRAS proto-oncogene, GTPase) - Rat Genome Database

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Gene: NRAS (NRAS proto-oncogene, GTPase) Pan paniscus
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Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
RGD ID: 11922198
Description: ENCODES a protein that exhibits GTPase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN defense response to protozoan (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation of angiogenesis (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN Golgi apparatus (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: GTPase NRas; neuroblastoma RAS viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,890,505 - 122,903,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
adult T-cell leukemia  (ISO)
anemia  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
bladder urothelial carcinoma  (ISO)
Brain Neoplasms  (ISO)
cervical cancer  (ISO)
cholangitis  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myeloid leukemia  (ISO)
chronic myelomonocytic leukemia  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
disease of cellular proliferation  (ISO)
epidermal nevus  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
hepatocellular carcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
large congenital melanocytic nevus  (ISO)
leukemia  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver carcinoma  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
Nasopharyngeal Neoplasms  (ISO)
neuroblastoma  (ISO)
Neurocutaneous Melanosis  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibrosarcoma  (ISO)
non-Hodgkin lymphoma  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 6  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Pigmented Nevus  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
prostate cancer  (ISO)
RASopathy  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland follicular carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
uterine cancer  (ISO)

References

Genomics

Comparative Map Data
NRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,890,505 - 122,903,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBIMhudiblu_PPA_v0panPan3
NRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,247,090 - 115,259,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
Nras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,965,601 - 102,975,230 (+)NCBIGRCm39mm39
GRCm39 Ensembl3102,965,601 - 102,975,230 (+)Ensembl
GRCm383103,058,285 - 103,067,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,058,285 - 103,067,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,862,208 - 102,871,837 (+)NCBIGRCm37mm9NCBIm37
MGSCv363103,187,290 - 103,197,396 (+)NCBImm8
Celera3105,263,160 - 105,272,744 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Nras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22190,582,885 - 190,593,509 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)Ensembl
Rnor_6.02205,553,119 - 205,563,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,983,707 - 224,994,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,292,650 - 198,300,286 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12198,255,369 - 198,265,062 (+)NCBI
Celera2183,056,304 - 183,063,940 (+)NCBICelera
Cytogenetic Map2q34NCBI
Nras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,001,517 - 18,009,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,001,517 - 18,009,105 (-)NCBIChiLan1.0ChiLan1.0
NRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,411,733 - 52,418,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,411,733 - 52,418,788 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,062,320 - 52,069,399 (-)NCBI
ROS_Cfam_1.01753,289,080 - 53,296,149 (-)NCBI
UMICH_Zoey_3.11752,323,232 - 52,330,285 (-)NCBI
UNSW_CanFamBas_1.01752,365,409 - 52,372,486 (-)NCBI
UU_Cfam_GSD_1.01752,938,741 - 52,945,813 (-)NCBI
Nras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,406,378 - 14,416,046 (+)NCBI
SpeTri2.0NW_00493662773,413 - 82,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,845,872 - 105,858,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,845,913 - 105,853,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,034,666 - 116,042,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,953,273 - 18,966,002 (+)NCBI
ChlSab1.1 Ensembl2018,953,883 - 18,961,931 (+)Ensembl
Vero_WHO_p1.0NW_02366603821,707,389 - 21,720,123 (+)NCBI
Nras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052658   ⟹   ENSPPAP00000029807
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052680   ⟹   ENSPPAP00000029828
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1122,891,712 - 122,900,313 (+)Ensembl
RefSeq Acc Id: XM_008973545   ⟹   XP_008971793
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11122,890,505 - 122,903,585 (+)NCBI
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034930093   ⟹   XP_034785984
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0187,837,743 - 87,850,013 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008971793 (Get FASTA)   NCBI Sequence Viewer  
  XP_034785984 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008971793   ⟸   XM_008973545
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034785984   ⟸   XM_034930093
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000029828   ⟸   ENSPPAT00000052680
RefSeq Acc Id: ENSPPAP00000029807   ⟸   ENSPPAT00000052658


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037915 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000029807 ENTREZGENE
NCBI Gene NRAS ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-08 NRAS  NRAS proto-oncogene, GTPase    neuroblastoma RAS viral oncogene homolog  Symbol and/or name change 5135510 APPROVED