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Gene: BCAR1 (BCAR1 scaffold protein, Cas family member) Homo sapiens
Symbol: BCAR1
Name: BCAR1 scaffold protein, Cas family member
Description: Exhibits protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to hepatocyte growth factor stimulus; and endothelin receptor signaling pathway. Localizes to cytoplasm; focal adhesion; and ruffle. Colocalizes with plasma membrane. Implicated in breast ductal carcinoma. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; CASS1; Crk-associated substrate p130Cas; CRKAS; FLJ12176; FLJ45059; P130Cas; v-crk-associated tyrosine kinase substrate
Mus musculus (house mouse) : Bcar1 (breast cancer anti-estrogen resistance 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcar1 (BCAR1 scaffold protein, Cas family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcar1 (BCAR1 scaffold protein, Cas family member)
Pan paniscus (bonobo/pygmy chimpanzee) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Canis lupus familiaris (dog) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcar1 (BCAR1 scaffold protein, Cas family member)
Sus scrofa (pig) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Chlorocebus sabaeus (African green monkey) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Heterocephalus glaber (naked mole-rat) : Bcar1 (BCAR1 scaffold protein, Cas family member)
more info ...
Related Pseudogenes: BCAR1P1   BCAR1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1675,228,181 - 75,268,053 (-)EnsemblGRCh38hg38GRCh38
GRCh381675,228,181 - 75,268,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371675,262,928 - 75,301,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,820,429 - 73,843,004 (-)NCBINCBI36hg18NCBI36
Build 341673,820,429 - 73,843,004NCBI
Celera1659,556,476 - 59,596,268 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1661,013,718 - 61,052,474 (-)NCBIHuRef
CHM1_11676,675,047 - 76,714,069 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BCAR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734116
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.