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ONTOLOGY REPORT - ANNOTATIONS


Term:autophagosome maturation
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Accession:GO:0097352 term browser browse the term
Definition:Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
Synonyms:exact_synonym: autophagic vacuole fusion;   autophagic vacuole maturation
 related_synonym: autophagosome fusion
 alt_id: GO:0000046



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autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 involved_in ISO (PMID:10625637) RGD PMID:10625637 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Becn1 beclin 1 involved_in ISO (PMID:10625637) RGD PMID:10625637 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Chmp1a charged multivesicular body protein 1A involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
JBrowse link
G Chmp1b charged multivesicular body protein 1B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr18:60,740,349...60,742,879 JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452
JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr11:3,338,007...3,364,357
Ensembl chr11:3,337,494...3,385,181
JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959
JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844
JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in ISO
IEA
(PMID:17984323)
GO_REF:0000107
RGD
Ensembl
PMID:17984323 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668
JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529
JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640
JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin acts_upstream_of_or_within ISO MGI:2388888 (MGI:3690270|PMID:16714284) RGD PMID:16714284 MGI:3690270 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434
JBrowse link
G Epg5 ectopic P-granules 5 autophagy tethering factor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5505596 (MGI:5488852|PMID:23479740)
RGD PMID:23479740 PMID:21873635 MGI:5488852, RGD:13792537 NCBI chr18:71,403,990...71,502,079
Ensembl chr18:71,404,010...71,501,502
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5805578|PMID:27628032)
PMID:21873635
UniProt
RGD
PMID:27628032 PMID:21873635 GO_REF:0000024 MGI:5805578, RGD:13792537 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lix1 limb and CNS expressed 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:58,128,961...58,187,554
Ensembl chr 1:58,128,961...58,185,964
JBrowse link
G Lix1l limb and CNS expressed 1 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:184,136,018...184,161,918
Ensembl chr 2:184,136,038...184,161,916
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha involved_in ISO
IBA
(PMID:28223137)
PMID:21873635
RGD PMID:28223137 PMID:21873635 RGD:13792537 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta involved_in ISO
IBA
(PMID:28223137)
PMID:21873635
RGD PMID:28223137 PMID:21873635 RGD:13792537 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map1lc3b2 microtubule-associated protein 1 light chain 3 beta 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:70,993,893...70,994,586
Ensembl chr16:70,994,128...70,994,606
JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 acts_upstream_of_or_within ISO MGI:3794204 (MGI:4839416|PMID:20600908) RGD PMID:20600908 MGI:4839416 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252
JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (MGI:6155546|PMID:29514215) RGD PMID:29514215 MGI:6155546 NCBI chr 2:123,822,042...123,882,913
Ensembl chr 2:123,816,614...123,857,971
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 involved_in ISO (PMID:10625637) RGD PMID:10625637 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 involved_in ISO (PMID:10625637) RGD PMID:10625637 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
JBrowse link
G Rubcnl rubicon like autophagy enhancer involved_in ISO
IBA
(PMID:28306502), (PMID:30704899)
(MGI:6282647|PMID:30704899)
PMID:21873635
RGD PMID:28306502 PMID:30704899 PMID:21873635 MGI:6282647, RGD:13792537 NCBI chr15:50,332,458...50,377,494
Ensembl chr15:50,332,418...50,400,849
JBrowse link
G Snap29 synaptosome associated protein 29 involved_in ISS
ISO
GO_REF:0000024
(PMID:23217709)
UniProt
RGD
PMID:23217709 GO_REF:0000024 NCBI chr11:83,578,479...83,608,953
Ensembl chr11:83,578,489...83,608,958
JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (MGI:4879078|PMID:20920792), (MGI:5504339|PMID:22797916) RGD PMID:20920792 PMID:22797916 MGI:4879078 MGI:5504339 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231
JBrowse link
G Snx14 sorting nexin 14 involved_in ISO
IBA
(PMID:25848753)
PMID:21873635
RGD PMID:25848753 PMID:21873635 RGD:13792537 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580
JBrowse link
G Stx17 syntaxin 17 involved_in ISO
ISS
(PMID:23217709), (PMID:24554770), (PMID:28306502)
GO_REF:0000024
RGD
UniProt
PMID:23217709 PMID:24554770 PMID:28306502 GO_REF:0000024 NCBI chr 5:62,446,138...62,506,108
Ensembl chr 5:62,446,187...62,504,451
JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:22342342)
UniProt
RGD
PMID:22342342 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611
JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:23459205)
Ensembl
RGD
PMID:23459205 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
JBrowse link
G Uvrag UV radiation resistance associated involved_in ISO (PMID:28306502) RGD PMID:28306502 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 NOT|involved_in ISO (PMID:23217709) RGD PMID:23217709 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in ISO
ISS
(PMID:23217709)
GO_REF:0000024
RGD
UniProt
PMID:23217709 GO_REF:0000024 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
G Vcp valosin-containing protein involved_in ISO
IBA
ISS
(PMID:20104022)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20104022 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vipas39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog NOT|involved_in ISO (PMID:25783203) RGD PMID:25783203 NCBI chr 6:106,888,284...106,913,139
Ensembl chr 6:106,888,284...106,913,117
JBrowse link
G Vps16 VPS16 core subunit of CORVET and HOPS complexes involved_in ISO (PMID:25783203) RGD PMID:25783203 NCBI chr 3:117,622,534...117,644,041
Ensembl chr 3:117,622,542...117,646,441
JBrowse link
G Vps33a VPS33A core subunit of CORVET and HOPS complexes involved_in ISO
IEA
(PMID:24554770), (PMID:25783203)
GO_REF:0000107
RGD
Ensembl
PMID:24554770 PMID:25783203 GO_REF:0000107 NCBI chr12:33,024,596...33,051,399
Ensembl chr12:33,024,650...33,051,393
JBrowse link
G Vps33b VPS33B, late endosome and lysosome associated NOT|involved_in ISO (PMID:25783203) RGD PMID:25783203 NCBI chr 1:134,223,967...134,247,232
Ensembl chr 1:134,223,949...134,246,970
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B NOT|involved_in ISO (PMID:23217709) RGD PMID:23217709 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465
JBrowse link
G Wipi2 WD repeat domain, phosphoinositide interacting 2 NOT|involved_in ISO (PMID:20505359) RGD PMID:20505359 NCBI chr12:11,911,369...11,939,799
Ensembl chr12:11,911,337...11,939,794
JBrowse link
autophagosome membrane docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 involved_in ISO (PMID:25686604) RGD PMID:25686604 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in ISO
ISS
(PMID:28890335)
GO_REF:0000024
RGD
UniProt
PMID:28890335 GO_REF:0000024 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Calm1 calmodulin 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:28890335)
UniProt
RGD
PMID:28890335 GO_REF:0000024 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:28890335)
UniProt
RGD
PMID:28890335 GO_REF:0000024 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:28890335)
UniProt
RGD
PMID:28890335 GO_REF:0000024 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Snap29 synaptosome associated protein 29 involved_in ISO (PMID:25686604) RGD PMID:25686604 NCBI chr11:83,578,479...83,608,953
Ensembl chr11:83,578,489...83,608,958
JBrowse link
G Stx17 syntaxin 17 involved_in ISO (PMID:25686604) RGD PMID:25686604 NCBI chr 5:62,446,138...62,506,108
Ensembl chr 5:62,446,187...62,504,451
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in ISO
IEA
(PMID:25686604)
GO_REF:0000107
RGD
Ensembl
PMID:25686604 GO_REF:0000107 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
G Vmp1 vacuole membrane protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:28890335)
UniProt
RGD
PMID:28890335 GO_REF:0000024 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
JBrowse link
negative regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
ISS
IBA
(PMID:25484098)
GO_REF:0000024
PMID:21873635
RGD
GO_Central
PMID:25484098 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:54,718,608...54,722,784
Ensembl chr10:54,717,724...54,722,782
JBrowse link
G Rubcn rubicon autophagy regulator involved_in IBA
ISO
PMID:21873635
(PMID:21062745)
RGD PMID:21062745 PMID:21873635 RGD:13792537 NCBI chr11:67,907,534...67,964,347
Ensembl chr11:67,907,516...67,964,314
JBrowse link
G Tmem39a transmembrane protein 39a involved_in ISO
IBA
ISS
(PMID:31806350)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:31806350 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:23459205) RGD PMID:23459205 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059
JBrowse link
positive regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025818.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:48,598,506...48,599,444 JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in ISO
ISS
(PMID:23708524)
GO_REF:0000024
RGD
GO_Central
PMID:23708524 GO_REF:0000024 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 involved_in ISO (PMID:25771791) RGD PMID:25771791 NCBI chr10:81,055,467...81,069,298 JBrowse link
G Clec16a C-type lectin domain containing 16A acts_upstream_of_or_within ISO MGI:5648633 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Fyco1 FYVE and coiled-coil domain autophagy adaptor 1 involved_in ISO
IBA
(PMID:26468287)
PMID:21873635
RGD PMID:26468287 PMID:21873635 RGD:13792537 NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021
JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:16888103)
(MGI:3656111|PMID:16888103)
RGD PMID:16888103 MGI:3656111 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
JBrowse link
G Tom1 target of myb1 membrane trafficking protein involved_in ISO (PMID:23023224) RGD PMID:23023224 NCBI chr19:13,405,482...13,440,384
Ensembl chr19:13,405,501...13,440,384
JBrowse link
regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 involved_in ISO (PMID:22342342) RGD PMID:22342342 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 involved_in ISO
IEA
(PMID:22342342)
GO_REF:0000107
RGD
Ensembl
PMID:22342342 GO_REF:0000107 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Clec16a C-type lectin domain containing 16A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,927,804...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) RGD PMID:26450516 MGI:5698740 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434
JBrowse link
G Tbc1d25 TBC1 domain family, member 25 involved_in ISO
IBA
(PMID:21383079)
PMID:21873635
RGD PMID:21383079 PMID:21873635 RGD:13792537 NCBI chr  X:14,314,095...14,339,171
Ensembl chr  X:14,314,414...14,338,275
JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 involved_in ISO (PMID:22342342) RGD PMID:22342342 NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      process utilizing autophagic mechanism 508
        autophagy 508
          macroautophagy 267
            autophagosome maturation 61
              autophagosome membrane docking 9
              negative regulation of autophagosome maturation 5
              positive regulation of autophagosome maturation 8
              regulation of autophagosome maturation + 17
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      catabolic process 2657
        cellular catabolic process 2129
          autophagy 508
            macroautophagy 267
              autophagosome maturation 61
                autophagosome membrane docking 9
                negative regulation of autophagosome maturation 5
                positive regulation of autophagosome maturation 8
                regulation of autophagosome maturation + 17
paths to the root