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Gene: Chmp2b (charged multivesicular body protein 2B) Rattus norvegicus
Symbol: Chmp2b
Name: charged multivesicular body protein 2B
Description: Predicted to have protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure and regulation of postsynapse organization. Localizes to the glutamatergic synapse and postsynaptic density. Predicted to colocalize with the late endosome; lysosome; and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 17; and frontotemporal dementia. Orthologous to human CHMP2B (charged multivesicular body protein 2B); PARTICIPATES IN autophagy pathway; endocytosis pathway; INTERACTS WITH 17beta-estradiol; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: MODEL
Also known as: chromatin modifying protein 2B; LOC363720; RGD1306781; similar to CGI-84 protein
Homo sapiens (human) : CHMP2B (charged multivesicular body protein 2B)  HGNC  Alliance
Mus musculus (house mouse) : Chmp2b (charged multivesicular body protein 2B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chmp2b (charged multivesicular body protein 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : CHMP2B (charged multivesicular body protein 2B)
Canis lupus familiaris (dog) : CHMP2B (charged multivesicular body protein 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chmp2b (charged multivesicular body protein 2B)
Sus scrofa (pig) : CHMP2B (charged multivesicular body protein 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0112,666,405 - 2,692,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0112,649,767 - 2,676,685 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,984,295 - 3,090,399 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1112,983,240 - 3,025,923 (-)NCBI
Celera113,315,643 - 3,340,019 (-)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Chmp2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306781
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.