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Gene: Chmp2b (charged multivesicular body protein 2B) Rattus norvegicus
Symbol: Chmp2b
Name: charged multivesicular body protein 2B
RGD ID: 1306781
Description: Predicted to have protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure. Localizes to glutamatergic synapse. Predicted to colocalize with late endosome; lysosome; and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 17; chromosome 3-linked frontotemporal dementia; and frontotemporal dementia. Orthologous to human CHMP2B (charged multivesicular body protein 2B); PARTICIPATES IN autophagy pathway; endocytosis pathway; INTERACTS WITH 17beta-estradiol; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: MODEL
Also known as: chromatin modifying protein 2B; LOC363720; RGD1306781; similar to CGI-84 protein
Homo sapiens (human) : CHMP2B (charged multivesicular body protein 2B)  HGNC  Alliance
Mus musculus (house mouse) : Chmp2b (charged multivesicular body protein 2B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chmp2b (charged multivesicular body protein 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : CHMP2B (charged multivesicular body protein 2B)
Canis lupus familiaris (dog) : CHMP2B (charged multivesicular body protein 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chmp2b (charged multivesicular body protein 2B)
Sus scrofa (pig) : CHMP2B (charged multivesicular body protein 2B)
Chlorocebus sabaeus (African green monkey) : CHMP2B (charged multivesicular body protein 2B)
Heterocephalus glaber (naked mole-rat) : Chmp2b (charged multivesicular body protein 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0112,666,405 - 2,692,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,665,285 - 2,692,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0112,649,767 - 2,676,685 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,984,295 - 3,090,399 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1112,983,240 - 3,025,923 (-)NCBI
Celera113,315,643 - 3,340,019 (-)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Chmp2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306781
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.