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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of canonical NF-kappaB signal transduction
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Accession:GO:0043124 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
Synonyms:exact_synonym: negative regulation of I-kappaB kinase/NF-kappaB signaling
 narrow_synonym: inhibition of I-kappaB kinase/NF-kappaB cascade
 related_synonym: down regulation of I-kappaB kinase/NF-kappaB cascade;   downregulation of I-kappaB kinase/NF-kappaB cascade;   negative regulation of I-kappaB kinase/NF-kappaB cascade


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negative regulation of canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Azi2 5-azacytidine induced gene 2 involved_in IDA (PMID:10580148) MGI PMID:10580148 NCBI chr 9:117,869,510...117,898,866
Ensembl chr 9:117,869,567...117,898,862 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:81,156,937...81,162,085
Ensembl chr10:81,156,937...81,162,076 		JBrowse link
G Casp8 caspase 8 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:7,460,048...7,471,659
Ensembl chr  X:7,460,048...7,471,756 		JBrowse link
G Coro1a coronin, actin binding protein 1A involved_in ISO (PMID:25093672) AgBase PMID:25093672 NCBI chr 7:126,298,946...126,303,925
Ensembl chr 7:126,298,945...126,306,959 		JBrowse link
G Dab2ip disabled 2 interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 involved_in IDA (MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:5009411 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Hdac1 histone deacetylase 1 acts_upstream_of_or_within IGI (PMID:19805123) MGI PMID:19805123 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Igtp interferon gamma induced GTPase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Irgm1 immunity-related GTPase family M member 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510 		JBrowse link
G Irgm2 immunity-related GTPase family M member 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Mapkbp1 mitogen-activated protein kinase binding protein 1 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:119,802,868...119,857,884
Ensembl chr 2:119,803,180...119,857,889 		JBrowse link
G Mir138-1 microRNA 138-1 involved_in ISO (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr 9:122,511,941...122,512,039
Ensembl chr 9:122,511,941...122,512,039 		JBrowse link
G Mir138-2 microRNA 138-2 involved_in ISO (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr 8:95,050,939...95,051,009
Ensembl chr 8:95,050,939...95,051,009 		JBrowse link
G Mir146 microRNA 146 involved_in ISO (PMID:25515214) ARUK-UCL PMID:25515214 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir15a microRNA 15a involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr14:61,869,476...61,869,559
Ensembl chr14:61,869,476...61,869,559 		JBrowse link
G Mir15b microRNA 15b involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr 3:68,917,105...68,917,168
Ensembl chr 3:68,917,105...68,917,168 		JBrowse link
G Mir16-1 microRNA 16-1 involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr14:61,869,329...61,869,421
Ensembl chr14:61,869,329...61,869,421 		JBrowse link
G Mir16-2 microRNA 16-2 involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr 3:68,917,235...68,917,329
Ensembl chr 3:68,917,235...68,917,329 		JBrowse link
G Mir195a microRNA 195a involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr11:70,125,868...70,125,961
Ensembl chr11:70,125,868...70,125,961 		JBrowse link
G Mir30c-2 microRNA 30c-2 involved_in ISO (PMID:25732226) ARUK-UCL PMID:25732226 NCBI chr 1:23,330,782...23,330,865
Ensembl chr 1:23,330,782...23,330,865 		JBrowse link
G Mir365-1 microRNA 365-1 involved_in ISO (PMID:30910589) ARUK-UCL PMID:30910589 NCBI chr16:13,271,704...13,271,790
Ensembl chr16:13,271,704...13,271,790 		JBrowse link
G Mir365-2 microRNA 365-2 involved_in ISO (PMID:30910589) ARUK-UCL PMID:30910589 NCBI chr11:79,617,226...79,617,337
Ensembl chr11:79,617,226...79,617,337 		JBrowse link
G Mir497 microRNA 497 involved_in ISO (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha involved_in ISO
IDA		 (PMID:7963540) MGI PMID:7963540 GO_REF:0000119 MGI:4834177 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta acts_upstream_of_or_within IDA (PMID:11931770) MGI PMID:11931770 NCBI chr 7:30,121,156...30,128,173
Ensembl chr 7:30,121,157...30,128,171 		JBrowse link
G Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 involved_in IDA (PMID:22024480) MGI PMID:22024480 NCBI chr17:35,439,151...35,455,457
Ensembl chr17:35,439,151...35,454,768 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in
acts_upstream_of_or_within		 IBA
IDA
ISO
IGI
IMP		 (PMID:22863753) GO_Central
MGI		 PMID:22863753 GO_REF:0000008 GO_REF:0000033 NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:3,267,317...3,298,400
Ensembl chr 7:3,267,458...3,298,370 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within IMP (PMID:22763455) MGI PMID:22763455 NCBI chr 7:140,500,777...140,509,105
Ensembl chr 7:140,500,815...140,509,105 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:21703540) GO_Central
MGI		 PMID:21703540 GO_REF:0000033 NCBI chr 9:44,164,010...44,179,896
Ensembl chr 9:44,164,014...44,179,896 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IMP (MGI:6283959|PMID:30792350) UniProt PMID:30792350 MGI:6283959 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in IMP
ISO		 (MGI:5707586|PMID:18972444) UniProt
MGI		 PMID:18972444 GO_REF:0000119 MGI:4834177 MGI:5707586 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Olfm4 olfactomedin 4 acts_upstream_of_or_within IDA (PMID:20534456) MGI PMID:20534456 NCBI chr14:80,237,742...80,260,581
Ensembl chr14:80,221,521...80,260,579 		JBrowse link
G Optn optineurin acts_upstream_of_or_within IMP (PMID:17702576) MGI PMID:17702576 NCBI chr 2:5,023,902...5,069,210
Ensembl chr 2:5,025,453...5,068,862 		JBrowse link
G Otud7b OTU domain containing 7B involved_in IMP
ISO		 (MGI:5474156|PMID:23334419) UniProt
MGI		 PMID:23334419 GO_REF:0000119 MGI:4834177 MGI:5474156 NCBI chr 3:96,011,759...96,068,446
Ensembl chr 3:96,011,839...96,068,446 		JBrowse link
G Per1 period circadian clock 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593 		JBrowse link
G Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr17:85,264,169...85,331,420
Ensembl chr17:85,264,169...85,331,419 		JBrowse link
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:19,010,730...19,014,047
Ensembl chr 7:19,010,730...19,013,989 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO RGD
MGI		 PMID:17615156 GO_REF:0000096 MGI:4417868 RGD:1642824 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rhoh ras homolog family member H involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:66,018,092...66,054,043
Ensembl chr 5:66,018,556...66,054,043 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:12,259,114...12,290,424
Ensembl chr18:12,261,798...12,290,444 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Rora RAR-related orphan receptor alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc39a8 solute carrier family 39 (metal ion transporter), member 8 acts_upstream_of_negative_effect ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333 		JBrowse link
G Snip1 Smad nuclear interacting protein 1 acts_upstream_of_or_within
involved_in		 IC
IDA		 (MGI:2154675|PMID:11567019)
(PMID:11567019)		 GOC
MGI		 PMID:11567019 MGI:2154675 NCBI chr 4:124,960,465...124,967,836
Ensembl chr 4:124,960,465...124,967,835 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tank TRAF family member-associated Nf-kappa B activator involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515 		JBrowse link
G Tgfbr3 transforming growth factor, beta receptor III involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495 		JBrowse link
G Tle1 transducin-like enhancer of split 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:72,028,182...72,124,575
Ensembl chr 4:72,036,042...72,119,130 		JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome acts_upstream_of_or_within_positive_effect ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr  X:165,990,089...165,996,475
Ensembl chr  X:165,990,089...165,992,311 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in IMP
ISO		 (MGI:3777503|PMID:18342009), (MGI:4946158|PMID:21088135) BHF-UCL
MGI		 PMID:18342009 PMID:21088135 GO_REF:0000119 MGI:3777503 MGI:4834177 MGI:4946158 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in IDA
ISO
IBA		 (MGI:5319605|PMID:18212736) UniProt
MGI
GO_Central		 PMID:18212736 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5319605 NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 acts_upstream_of_or_within IDA (PMID:11390377) MGI PMID:11390377 NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335 		JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:65,567,382...65,611,024
Ensembl chr 6:65,502,297...65,611,024 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IMP (MGI:6695683|PMID:29663649) ARUK-UCL PMID:29663649 MGI:6695683 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
G Trim39 tripartite motif-containing 39 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:36,569,764...36,582,896
Ensembl chr17:36,569,765...36,583,139 		JBrowse link
G Trim59 tripartite motif-containing 59 acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 (PMID:22588174) MGI
GO_Central		 PMID:22588174 GO_REF:0000008 GO_REF:0000033 NCBI chr 3:68,942,625...68,952,075
Ensembl chr 3:68,942,621...68,952,088 		JBrowse link
G Tspan6 tetraspanin 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:132,791,817...132,801,957
Ensembl chr  X:132,791,817...132,799,178 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats involved_in IMP (PMID:14961764) MGI PMID:14961764 NCBI chr 9:60,700,488...60,787,713
Ensembl chr 9:60,701,824...60,787,652 		JBrowse link
G Usp10 ubiquitin specific peptidase 10 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:120,637,099...120,684,299
Ensembl chr 8:120,637,099...120,684,299 		JBrowse link
G Usp20 ubiquitin specific peptidase 20 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:30,872,291...30,912,667
Ensembl chr 2:30,872,291...30,913,598 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in IDA
ISO		 (MGI:5142149|PMID:21616078) UniProt
MGI		 PMID:21616078 GO_REF:0000119 MGI:4834177 MGI:5142149 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633 		JBrowse link
G Zmynd11 zinc finger, MYND domain containing 11 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:9,734,872...9,816,050
Ensembl chr13:9,734,869...9,815,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    negative regulation of biological process 5939
      negative regulation of signaling 1647
        negative regulation of signal transduction 1501
          negative regulation of intracellular signal transduction 649
            negative regulation of canonical NF-kappaB signal transduction 73
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13127
      regulation of biological process 12732
        signaling 7290
          signal transduction 6676
            intracellular signal transduction 2808
              intracellular signaling cassette 1948
                canonical NF-kappaB signal transduction 336
                  regulation of canonical NF-kappaB signal transduction 312
                    negative regulation of canonical NF-kappaB signal transduction 73
paths to the root