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Gene: Trem2 (triggering receptor expressed on myeloid cells 2) Mus musculus
Symbol: Trem2
Name: triggering receptor expressed on myeloid cells 2
Description: Exhibits several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including glial cell activation; positive regulation of intracellular signal transduction; and response to bacterium. Localizes to the integral component of plasma membrane. Used to study frontotemporal dementia. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381748,346,401 - 48,352,276 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371748,485,726 - 48,491,598 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,811,968 - 47,817,840 (+)NCBImm8
Celera1751,775,275 - 51,781,150 (+)NCBICelera
Cytogenetic Map17 CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trem2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320402
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.