Igtp (interferon gamma induced GTPase) - Rat Genome Database
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Gene: Igtp (interferon gamma induced GTPase) Mus musculus
Analyze
No known orthologs.
Symbol: Igtp
Name: interferon gamma induced GTPase
RGD ID: 1315773
MGI Page MGI
Description: Exhibits GTPase activity. Involved in cellular response to interferon-beta. Localizes to cytosol. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW558444; Irg; Irgm3; MGC102455; MGC5712
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,090,382 - 58,098,418 (+)NCBIGRCm39mm39
GRCm381158,199,556 - 58,207,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,199,556 - 58,207,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,013,058 - 58,021,094 (+)NCBIGRCm37mm9NCBIm37
MGSCv361158,015,751 - 58,023,786 (+)NCBImm8
Celera1162,953,297 - 62,961,257 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1136.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
GTPase activity  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8702776   PMID:10189358   PMID:10349636   PMID:10639151   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11457893   PMID:12438372   PMID:12477932   PMID:12819192   PMID:14681479  
PMID:14707092   PMID:15177550   PMID:15908352   PMID:16141072   PMID:16141073   PMID:16469053   PMID:16940170   PMID:16959883   PMID:17641048   PMID:17982087   PMID:18371424   PMID:18424746  
PMID:18452580   PMID:18765738   PMID:18772884   PMID:19158679   PMID:19176402   PMID:19265156   PMID:19699172   PMID:20029464   PMID:21267068   PMID:21633090   PMID:21677750   PMID:21731484  
PMID:21757726   PMID:21873635   PMID:22855710   PMID:23633952   PMID:23785284   PMID:24715728   PMID:25356593   PMID:25644000   PMID:27001747   PMID:28193861   PMID:31648279  


Genomics

Position Markers
AW558444  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381158,207,275 - 58,207,419UniSTSGRCm38
MGSCv371158,020,777 - 58,020,921UniSTSGRCm37
Celera1162,960,940 - 62,961,084UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11766.23UniSTS
Igtp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11890000061500000Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112588179959881914Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112827504662275149Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113787775360511890Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:950
Count of miRNA genes:323
Interacting mature miRNAs:376
Transcripts:ENSMUST00000035266, ENSMUST00000094169, ENSMUST00000168280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA275064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU695229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035266   ⟹   ENSMUSP00000047356
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1158,199,556 - 58,207,591 (+)Ensembl
RefSeq Acc Id: ENSMUST00000094169   ⟹   ENSMUSP00000091721
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1158,199,586 - 58,207,565 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168280   ⟹   ENSMUSP00000130878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1158,199,588 - 58,207,575 (+)Ensembl
RefSeq Acc Id: NM_018738   ⟹   NP_061208
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391158,090,382 - 58,098,418 (+)NCBI
GRCm381158,199,556 - 58,207,592 (+)ENTREZGENE
MGSCv371158,013,058 - 58,021,094 (+)RGD
Celera1162,953,297 - 62,961,257 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061208   ⟸   NM_018738
- UniProtKB: Q9DCE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130878   ⟸   ENSMUST00000168280
RefSeq Acc Id: ENSMUSP00000091721   ⟸   ENSMUST00000094169
RefSeq Acc Id: ENSMUSP00000047356   ⟸   ENSMUST00000035266
Protein Domains
IRG-type G

Promoters
RGD ID:6821127
Promoter ID:MM_KWN:7543
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell
Transcripts:NM_018738,   UC007JAQ.1,   UC007JAR.1,   UC007JAT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361158,012,691 - 58,013,191 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107729 AgrOrtholog
Ensembl Genes ENSMUSG00000037258
  ENSMUSG00000078853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000047356 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000091721 UniProtKB/TrEMBL
  ENSMUSP00000130878 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035266 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000094169 UniProtKB/TrEMBL
  ENSMUST00000168280 UniProtKB/TrEMBL
InterPro G_IRG_dom UniProtKB/TrEMBL
  Interferon-induced_GTPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report mmu:16145 UniProtKB/TrEMBL
MGD MGI:107729 ENTREZGENE
NCBI Gene 16145 ENTREZGENE
Pfam IIGP UniProtKB/TrEMBL
PhenoGen Igtp PhenoGen
PROSITE G_IRG UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt E9PW35_MOUSE UniProtKB/TrEMBL
  E9Q9N8_MOUSE UniProtKB/TrEMBL
  Q3U5T3_MOUSE UniProtKB/TrEMBL
  Q811M6_MOUSE UniProtKB/TrEMBL
  Q8C2M8_MOUSE UniProtKB/TrEMBL
  Q9DCE9 ENTREZGENE, UniProtKB/TrEMBL