Enables GTPase activity. Involved in several processes, including defense response to other organism; negative regulation of PERK-mediated unfolded protein response; and positive regulation of autophagosome maturation. Acts upstream of or within cellular response to interferon-beta. Located in cytosol. Is active in endoplasmic reticulum. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).
[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of IGTP mRNA
[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of IGTP mRNA
[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of IGTP mRNA
[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of IGTP mRNA
[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of IGTP mRNA
(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IGTP mRNA] and methyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IGTP mRNA]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of IGTP mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of IGTP mRNA
[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IGTP mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of IGTP mRNA