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Gene: Igtp (interferon gamma induced GTPase) Mus musculus
Analyze
Symbol:
Igtp
Name:
interferon gamma induced GTPase
RGD ID:
1315773
MGI Page
MGI
Description:
Exhibits GTPase activity. Involved in cellular response to interferon-beta. Localizes to cytosol. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AW558444; Irg; Irgm3; MGC102455; MGC5712
RGD Orthologs
Alliance Genes
No known orthologs.
More Info
homologs ...
More Info
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 11 58,090,382 - 58,098,418 (+) NCBI GRCm39 mm39 GRCm38 11 58,199,556 - 58,207,592 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 11 58,199,556 - 58,207,591 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 11 58,013,058 - 58,021,094 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 11 58,015,751 - 58,023,786 (+) NCBI mm8 Celera 11 62,953,297 - 62,961,257 (+) NCBI Celera Cytogenetic Map 11 B1.3 NCBI cM Map 11 36.01 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of IGTP mRNA CTD PMID:22206623 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGTP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGTP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of IGTP mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of IGTP mRNA CTD PMID:26377647 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IGTP mRNA CTD PMID:17982090 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of IGTP mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of IGTP mRNA CTD PMID:28973697 benzene increases expression EXP 6480464 Benzene results in increased expression of IGTP mRNA CTD PMID:15120971 , PMID:15122651 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein affects the reaction [Benzoapyrene affects the expression of IGTP mRNA] CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzoapyrene results in increased expression of IGTP mRNA CTD PMID:23735875 benzo[a]pyrene decreases expression EXP 6480464 Benzoapyrene results in decreased expression of IGTP mRNA CTD PMID:20713471 , PMID:21964900 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of IGTP mRNA CTD PMID:25554681 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of IGTP mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes more ... CTD PMID:25620056 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of IGTP mRNA CTD PMID:18353800 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of IGTP mRNA CTD PMID:21139344 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of IGTP mRNA CTD PMID:22733784 dextran sulfate increases expression EXP 6480464 Dextran Sulfate results in increased expression of IGTP mRNA CTD PMID:23894361 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:26377693 folpet decreases expression EXP 6480464 folpet results in decreased expression of IGTP mRNA CTD PMID:31558096 lipopolysaccharide multiple interactions EXP 6480464 +-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IGTP mRNA], methyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IGTP mRNA] CTD PMID:24056979 , PMID:25890327 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of IGTP mRNA CTD PMID:17321000 more ... lipopolysaccharide affects expression EXP 6480464 Lipopolysaccharides affects the expression of IGTP mRNA CTD PMID:24056979 metam multiple interactions EXP 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides affects the expression of IGTP mRNA] CTD PMID:24056979 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of IGTP protein CTD PMID:26984711 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of IGTP mRNA CTD PMID:23892564 pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of IGTP mRNA] CTD PMID:17321000 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of IGTP mRNA CTD PMID:17321000 more ... silver atom affects expression EXP 6480464 Silver affects the expression of IGTP mRNA CTD PMID:27131904 silver(0) affects expression EXP 6480464 Silver affects the expression of IGTP mRNA CTD PMID:27131904 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of IGTP mRNA CTD PMID:31558096 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of IGTP mRNA CTD PMID:21641980 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of IGTP mRNA CTD PMID:20937368 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of IGTP mRNA CTD PMID:14729362 , PMID:15003993 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of IGTP mRNA CTD PMID:31919559 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of IGTP mRNA CTD PMID:23557971 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of IGTP mRNA CTD PMID:27760801 trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGTP mRNA CTD PMID:18930950 vancomycin decreases expression EXP 6480464 Vancomycin results in decreased expression of IGTP mRNA CTD PMID:18930951
Imported Annotations - KEGG (archival)
References
Additional References at PubMed
Genomics
QTLs in Region (GRCm38)
27226798 Scvln18_m sacral vertebrae length 2, 16 week (mouse) 11 3300000 60800000 Mouse 26884446 Sklq10_m skull length QTL 10, 10 week (mouse) 11 3300000 63000000 Mouse 26884453 Sklq16_m skull length QTL 16, 16 week (mouse) 11 3300000 72800000 Mouse 13208559 Wght10_m weight 10 (mouse) 11 4000000 89000000 Mouse 13208558 Lgth12_m body length 12 (mouse) 11 4000000 95000000 Mouse 1300905 Scc6_m colon tumor susceptibility 6 (mouse) Not determined 11 6930277 89128908 Mouse 27226738 Metcl11_m metatarsal-calcaneal length 11, 10 week (mouse) 11 8900000 61500000 Mouse 26884401 Huml4_m humerus length 4, 10 week (mouse) 11 11600000 68600000 Mouse 27226762 Feml21_m femur length 21, 16 week (mouse) 11 11800000 66100000 Mouse 4141966 Tailq1_m tail length QTL 1 (mouse) Not determined 12318637 68609504 Mouse 1357851 Scfq3_m subcutaneous fat pad weight QTL 3 (mouse) Not determined 11 12318637 68609504 Mouse 1357437 Epfq4_m epididymal fat pad weight QTL 4 (mouse) Not determined 11 12318637 68609504 Mouse 4141127 W3q4_m weight 3 weeks QTL 4 (mouse) Not determined 12318637 68609504 Mouse 4142216 Lgq1_m late growth QTL 1 (mouse) Not determined 12318637 68609504 Mouse 4142308 W6q3_m weight 6 weeks QTL 3 (mouse) Not determined 11 12318637 68609504 Mouse 4141582 Lgaq1_m late growth adjusted QTL 1 (mouse) Not determined 12318637 68609504 Mouse 4142109 W10q2_m weight 10 weeks QTL 2 (mouse) Not determined 12318637 68609504 Mouse 4141470 Egq4_m early growth QTL 4 (mouse) Not determined 12318637 68609504 Mouse 1357640 Orq2_m ovulation rate QTL 2 (mouse) Not determined 11 12318637 68609504 Mouse 1357720 Kidpq1_m kidney weight percentage QTL 1 (mouse) Not determined 11 12318637 68609504 Mouse 1559002 Lmrq4_m Leishmania major resistance QTL 4 (mouse) Not determined 11 12318637 69794121 Mouse 1357859 Lvrq7_m liver weight QTL 7 (mouse) Not determined 11 12318637 118131898 Mouse 39128214 Lwq20_m liver weight QTL 20 (mouse) 11 12318637 118131898 Mouse 1558945 Orgwq8_m organ weight QTL 8 (mouse) Not determined 11 17106175 67187585 Mouse 10053687 Eae6_m susceptibility to experimental allergic encephalomyelitis 6 (mouse) Not determined 11 17831966 68609504 Mouse 4141894 Nidd6k_m Nidd6 on KK-A (mouse) Not determined 19174204 97007000 Mouse 10412246 Dfs2_m dental fluorosis suseptibility 2 (mouse) Not determined 11 21857364 95990405 Mouse 10044006 Hbnr13_m Heligmosomoides bakeri nematode resistance 13 (mouse) Not determined 11 25881799 59881914 Mouse 1357844 Si5lq5_m serum IGFBP-5 level QTL 5 (mouse) Not determined 11 28275046 62275149 Mouse 13524848 Ppiq7_m prepulse inhibition QTL 7 (mouse) 11 28678320 62678320 Mouse 1301426 Desp2_m despair 2 (mouse) Not determined 11 28817754 62817873 Mouse 11522752 Cocia18_m cocaine-induced activity, QTL 18 (mouse) 11 31117382 65117382 Mouse 11059563 Lmr31_m leishmaniasis resistance 31 (mouse) 11 32209750 66209867 Mouse 1357782 Char8_m P. chabaudi malaria resistance QTL 8 (mouse) Not determined 11 35687789 69794161 Mouse 13208569 Bmiq10_m body mass index QTL 10 (mouse) 11 36000000 85000000 Mouse 1301328 Mol4_m modifier of LPS-response 4 (mouse) Not determined 11 36391750 83590530 Mouse 1301788 Lbw8_m lupus NZB x NZW 8 (mouse) Not determined 11 36612460 70618665 Mouse 1301896 Tria1_m T-cell receptor induced activation 1 (mouse) Not determined 11 36722738 70723028 Mouse 4141853 Skmw17_m skeletal muscle weight 17 (mouse) Not determined 11 37190115 71190238 Mouse 4142475 Ity2a_m immunity to S. typhimurium 2a (mouse) Not determined 11 37877753 60511890 Mouse 10766457 Nwa3_m New Zealand White autoimmunity 3 (mouse) 11 38125289 72125383 Mouse 11532698 Sluc36a_m susceptibility to lung cancer 36a (mouse) 11 42365791 76365904 Mouse 11532699 Sluc36b_m susceptibility to lung cancer 36b (mouse) 11 42365791 76365904 Mouse 4142300 Ctrq3_m C. trachomatis resistance QTL 3 (mouse) Not determined 11 44739211 76963931 Mouse 4141367 Inf1_m acute ozone induced inflammation (mouse) Not determined 44739211 113167183 Mouse 4141000 Nidd3_m non-insulin-dependent diabetes mellitus 3 (mouse) Not determined 45151201 79151308 Mouse 1302021 Nidd1n_m non-insulin-dependent diabetes mellitus 1 in NSY (mouse) Not determined 11 45275046 80087498 Mouse 1357878 Mastr_m modifier of astrocytoma (mouse) Not determined 11 45817754 89927907 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 46294341 80294436 Mouse 1301988 Bmd11_m bone mineral density 11 (mouse) Not determined 11 46428581 80428696 Mouse 1301830 Ssta4_m susceptibility to Salmonella typhimurium antigens 4 (mouse) Not determined 11 50187365 84187585 Mouse 13524840 Ppiq9a_m prepulse inhibition QTL 9a (mouse) 11 52603559 86603559 Mouse 1300774 Pgia7_m proteoglycan induced arthritis 7 (mouse) Not determined 11 53499762 87499911 Mouse 4141084 Spqq1_m sperm quality QTL 1 (mouse) Not determined 54174844 63428696 Mouse 1302186 Blmpf2_m bleomycin-induced pulmonary fibrosis 2 (mouse) Not determined 11 54174844 67187585 Mouse 4142148 Ckdbp2_m chronic kidney disease blood pressure locus 2 (mouse) Not determined 11 54190115 65213015 Mouse 4141830 Pregq1_m pregnancy QTL 1 (mouse) Not determined 11 54235926 83842826 Mouse 4141875 Etax9_m ethanol induced ataxia 9 (mouse) Not determined 55394159 72319101 Mouse 4142121 Tmc1m2_m Tmc1 modifier 2 (mouse) Not determined 11 56973201 114267131 Mouse 1300664 Etohcta9_m ethanol conditioned taste aversion 9 (mouse) Not determined 11 57863834 91863932 Mouse
