Igtp (interferon gamma induced GTPase) - Rat Genome Database

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Gene: Igtp (interferon gamma induced GTPase) Mus musculus
Analyze
No known orthologs.
Symbol: Igtp
Name: interferon gamma induced GTPase
RGD ID: 1315773
MGI Page MGI
Description: Enables GTPase activity. Involved in several processes, including defense response to other organism; negative regulation of PERK-mediated unfolded protein response; and positive regulation of autophagosome maturation. Acts upstream of or within cellular response to interferon-beta. Located in cytosol. Is active in endoplasmic reticulum. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW558444; immunity-related GTPase family M protein 3; Irg; Irgm3; MGC102455; MGC5712
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,090,382 - 58,098,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,090,382 - 58,098,417 (+)EnsemblGRCm39 Ensembl
GRCm381158,199,556 - 58,207,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,199,556 - 58,207,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,013,058 - 58,021,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,015,751 - 58,023,786 (+)NCBIMGSCv36mm8
Celera1162,953,297 - 62,961,257 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1136.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (IBA,ISO)
autophagy  (IEA)
CAMKK-AMPK signaling cascade  (ISO)
CD8-positive, alpha-beta T cell differentiation  (IDA)
cellular response to interferon-beta  (IBA,IDA)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (IDA)
cellular response to virus  (ISO)
cytolysis in another organism  (IDA)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to protozoan  (IDA,IMP)
immune system process  (IEA)
innate immune response  (IBA,IMP,ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cGAS/STING signaling pathway  (ISO)
negative regulation of defense response to virus  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of PERK-mediated unfolded protein response  (IDA)
negative regulation of type I interferon production  (ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of autophagosome maturation  (IDA,ISO)
positive regulation of autophagy  (ISO)
positive regulation of lysosome organization  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of mitophagy  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of type II interferon-mediated signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
protein destabilization  (ISO)
protein stabilization  (ISO)
protein targeting to vacuole involved in autophagy  (ISO)
protein-containing complex assembly  (ISO)
regulation of protein complex stability  (ISO)
regulation of protein-containing complex assembly  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8702776   PMID:9099712   PMID:10189358   PMID:10349636   PMID:10639151   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11457893   PMID:11500431   PMID:12438372   PMID:12477932  
PMID:12819192   PMID:14681479   PMID:14707092   PMID:15177550   PMID:15908352   PMID:16141072   PMID:16141073   PMID:16469053   PMID:16940170   PMID:16959883   PMID:17641048   PMID:17982087  
PMID:18371424   PMID:18424746   PMID:18452580   PMID:18765738   PMID:18772884   PMID:19158679   PMID:19176402   PMID:19265156   PMID:19699172   PMID:20029464   PMID:21267068   PMID:21633090  
PMID:21677750   PMID:21731484   PMID:21757726   PMID:21873635   PMID:21981022   PMID:22855710   PMID:23633952   PMID:23785284   PMID:24715728   PMID:25356593   PMID:25644000   PMID:26440898  
PMID:27001747   PMID:28193861   PMID:30550785   PMID:31648279   PMID:33124745   PMID:34078740   PMID:34338548   PMID:34655526   PMID:34694641   PMID:35941154  


Genomics

Variants

.
Variants in Igtp
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:950
Count of miRNA genes:323
Interacting mature miRNAs:376
Transcripts:ENSMUST00000035266, ENSMUST00000094169, ENSMUST00000168280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse

Markers in Region
AW558444  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381158,207,275 - 58,207,419UniSTSGRCm38
MGSCv371158,020,777 - 58,020,921UniSTSGRCm37
Celera1162,960,940 - 62,961,084UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11766.23UniSTS
Igtp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA275064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU695229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000035266   ⟹   ENSMUSP00000047356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1158,090,382 - 58,098,417 (+)Ensembl
GRCm38.p6 Ensembl1158,199,556 - 58,207,591 (+)Ensembl
RefSeq Acc Id: ENSMUST00000094169   ⟹   ENSMUSP00000091721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1158,090,412 - 58,098,391 (+)Ensembl
GRCm38.p6 Ensembl1158,199,586 - 58,207,565 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168280   ⟹   ENSMUSP00000130878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1158,090,414 - 58,098,401 (+)Ensembl
GRCm38.p6 Ensembl1158,199,588 - 58,207,575 (+)Ensembl
RefSeq Acc Id: NM_018738   ⟹   NP_061208
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391158,090,382 - 58,098,418 (+)NCBI
GRCm381158,199,556 - 58,207,592 (+)ENTREZGENE
MGSCv371158,013,058 - 58,021,094 (+)RGD
Celera1162,953,297 - 62,961,257 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_061208   ⟸   NM_018738
- UniProtKB: J7PDL1 (UniProtKB/Swiss-Prot),   Q8C2M8 (UniProtKB/Swiss-Prot),   Q9DCE9 (UniProtKB/TrEMBL),   Q811M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130878   ⟸   ENSMUST00000168280
RefSeq Acc Id: ENSMUSP00000091721   ⟸   ENSMUST00000094169
RefSeq Acc Id: ENSMUSP00000047356   ⟸   ENSMUST00000035266
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DCE9-F1-model_v2 AlphaFold Q9DCE9 1-423 view protein structure

Promoters
RGD ID:6821127
Promoter ID:MM_KWN:7543
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell
Transcripts:NM_018738,   UC007JAQ.1,   UC007JAR.1,   UC007JAT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361158,012,691 - 58,013,191 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107729 AgrOrtholog
Ensembl Genes ENSMUSG00000037258
  ENSMUSG00000078853 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035266 ENTREZGENE
  ENSMUST00000035266.11 UniProtKB/Swiss-Prot
  ENSMUST00000094169.11 UniProtKB/TrEMBL
  ENSMUST00000168280.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
InterPro G_IRG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunity-related_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16145 UniProtKB/Swiss-Prot
MGD MGI:107729 ENTREZGENE
NCBI Gene 16145 ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY M MEMBER 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IIGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igtp PhenoGen
PROSITE G_IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PW35_MOUSE UniProtKB/TrEMBL
  E9Q9N8_MOUSE UniProtKB/TrEMBL
  IRGM3_MOUSE UniProtKB/Swiss-Prot
  J7PDL1 ENTREZGENE
  Q3U5T3_MOUSE UniProtKB/TrEMBL
  Q811M6 ENTREZGENE, UniProtKB/TrEMBL
  Q8C2M8 ENTREZGENE
  Q9DCE9 ENTREZGENE
UniProt Secondary J7PDL1 UniProtKB/Swiss-Prot
  Q8C2M8 UniProtKB/Swiss-Prot