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Ontology Browser

Term:
negative regulation of intracellular signal transduction (GO:1902532)
Annotations: Rat: (546) Mouse: (533) Human: (566) Chinchilla: (492) Bonobo: (504) Dog: (525) Squirrel: (497) Pig: (526)
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
extracellular negative regulation of signal transduction +   
hippo signaling +   
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
metarhodopsin inactivation 
negative adaptation of signaling pathway +   
negative regulation of abscisic acid-activated signaling pathway 
negative regulation of anti-Mullerian hormone signaling pathway  
negative regulation of antigen receptor-mediated signaling pathway +   
negative regulation of apolipoprotein A-I-mediated signaling pathway 
negative regulation of apoptotic signaling pathway +   
negative regulation of auxin mediated signaling pathway 
negative regulation of brain-derived neurotrophic factor receptor signaling pathway +   
negative regulation of brassinosteroid mediated signaling pathway 
negative regulation of CD40 signaling pathway  
negative regulation of chemorepellent activity 
negative regulation of corticotropin-releasing hormone receptor activity  
negative regulation of cytokine activity +   
negative regulation of cytokine-mediated signaling pathway +   
negative regulation of cytokinin-activated signaling pathway 
negative regulation of dopamine receptor signaling pathway +   
negative regulation of endoplasmic reticulum unfolded protein response +   
negative regulation of ephrin receptor signaling pathway 
negative regulation of ERBB signaling pathway +   
negative regulation of excitatory postsynaptic potential +   
negative regulation of Fas signaling pathway  
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  
negative regulation of fibroblast growth factor receptor signaling pathway +   
negative regulation of G protein-coupled receptor signaling pathway +   
negative regulation of gibberellic acid mediated signaling pathway 
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  
negative regulation of glucocorticoid mediated signaling pathway  
negative regulation of glucose mediated signaling pathway +  
negative regulation of glutamate receptor signaling pathway +   
negative regulation of growth hormone activity 
negative regulation of growth hormone receptor signaling pathway  
negative regulation of hepatocyte growth factor receptor signaling pathway  
negative regulation of hypoxia-inducible factor-1alpha signaling pathway  
negative regulation of insulin receptor signaling pathway +   
negative regulation of insulin-like growth factor receptor signaling pathway  
negative regulation of integrin-mediated signaling pathway  
negative regulation of intracellular signal transduction +   
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
negative regulation of intracellular steroid hormone receptor signaling pathway +   
negative regulation of lipopolysaccharide-mediated signaling pathway +   
negative regulation of nerve growth factor receptor activity 
negative regulation of netrin-activated signaling pathway  
negative regulation of neuronal signal transduction 
negative regulation of neurotrophin TRK receptor signaling pathway  
negative regulation of Notch signaling pathway +   
negative regulation of osmosensory signaling pathway 
negative regulation of peptidoglycan recognition protein signaling pathway 
negative regulation of peroxisome proliferator activated receptor signaling pathway  
negative regulation of platelet-derived growth factor receptor signaling pathway +   
negative regulation of receptor signaling pathway via STAT +   
negative regulation of red or far-red light signaling pathway 
negative regulation of retinoic acid receptor signaling pathway  
negative regulation of Roundabout signaling pathway +  
negative regulation of semaphorin-plexin signaling pathway 
negative regulation of sevenless signaling pathway 
negative regulation of signal transduction by receptor internalization +  
negative regulation of signal transduction in absence of ligand +   
negative regulation of signal transduction involved in conjugation with cellular fusion +  
negative regulation of smoothened signaling pathway +   
negative regulation of sphingolipid mediated signaling pathway 
negative regulation of SREBP signaling pathway +   
negative regulation of thyroid hormone mediated signaling pathway 
negative regulation of Toll signaling pathway  
negative regulation of toll-like receptor signaling pathway +   
negative regulation of torso signaling pathway 
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +   
negative regulation of vascular endothelial growth factor receptor signaling pathway  
negative regulation of vascular endothelial growth factor signaling pathway  
negative regulation of vitamin D receptor signaling pathway  
negative regulation of Wnt signaling pathway +   
NIK/NF-kappaB signaling +   
phosphorelay signal transduction system +   
PKR-mediated signaling 
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of calcium-mediated signaling +   
regulation of cAMP-mediated signaling +   
regulation of cGMP-mediated signaling +   
regulation of hippo signaling +   
regulation of I-kappaB kinase/NF-kappaB signaling +   
regulation of intracellular signal transduction +   
regulation of intrinsic apoptotic signaling pathway +   
regulation of MAPK cascade +   
regulation of NIK/NF-kappaB signaling +   
regulation of nitric oxide mediated signal transduction +   
regulation of nucleotide-binding oligomerization domain containing signaling pathway +   
regulation of phosphatidylinositol 3-kinase signaling +   
regulation of phosphorelay signal transduction system +  
regulation of protein kinase A signaling +   
regulation of protein kinase B signaling +   
regulation of protein kinase C signaling +   
regulation of protein kinase D signaling +   
regulation of signal transduction by p53 class mediator +   
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint +   
regulation of small GTPase mediated signal transduction +   
regulation of stress-activated protein kinase signaling cascade +   
regulation of TOR signaling +   
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway 
suppression by symbiont of host cAMP-mediated signal transduction 
termination of signal transduction +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Exact Synonyms: down regulation of intracellular signal transduction ;   down regulation of intracellular signaling chain ;   downregulation of intracellular signal transduction ;   downregulation of intracellular signaling chain ;   negative regulation of intracellular protein kinase cascade ;   negative regulation of intracellular signaling cascade ;   negative regulation of intracellular signaling chain
Narrow Synonyms: down regulation of intracellular signal transduction pathway ;   downregulation of intracellular signal transduction pathway ;   downregulation of intracellular signaling cascade ;   downregulation of signal transmission via intracellular cascade ;   inhibition of intracellular signal transduction ;   inhibition of intracellular signal transduction pathway ;   inhibition of intracellular signaling cascade ;   inhibition of intracellular signaling chain ;   inhibition of signal transmission via intracellular cascade ;   negative regulation of intracellular signal transduction pathway ;   negative regulation of signal transmission via intracellular cascade
Related Synonyms: down regulation of intracellular signaling pathway ;   down regulation of signal transduction via intracellular signaling cascade ;   down-regulation of intracellular signaling cascade ;   down-regulation of signal transmission via intracellular cascade ;   downregulation of intracellular signaling pathway ;   downregulation of signal transduction via intracellular signaling cascade ;   inhibition of intracellular signaling pathway ;   inhibition of signal transduction via intracellular signaling cascade ;   negative regulation of intracellular signaling pathway ;   negative regulation of signal transduction via intracellular signaling cascade
Alternate IDs: GO:0010741
Definition Sources: GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.