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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of inflammasome-mediated signaling pathway
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Accession:GO:0141085 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway.
Synonyms:exact_synonym: regulation of inflammasome-mediated signal transduction


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negative regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trim11 tripartite motif-containing 11 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27498865)		 UniProt
RGD		 PMID:27498865 GO_REF:0000024 NCBI chr10:43,758,299...43,771,138
Ensembl chr10:43,758,354...43,771,138 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd17a abhydrolase domain containing 17A, depalmitoylase involved_in ISO (PMID:38092000) RGD PMID:38092000 NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762 		JBrowse link
G Cptp ceramide-1-phosphate transfer protein involved_in ISO
ISS		 (PMID:29164996)
GO_REF:0000024		 RGD
UniProt		 PMID:29164996 GO_REF:0000024 NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:34615873)		 UniProt
RGD		 PMID:34615873 GO_REF:0000024 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 involved_in ISO (PMID:26037928) RGD PMID:26037928 NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in ISO (PMID:36586411) RGD PMID:36586411 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
ISO		 GO_REF:0000024
(PMID:30612879)		 UniProt
RGD		 PMID:30612879 GO_REF:0000024 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISO (PMID:36586411) RGD PMID:36586411 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in ISS
ISO		 GO_REF:0000024
(PMID:26347139)		 UniProt
RGD		 PMID:26347139 GO_REF:0000024 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:25277106) RGD PMID:25277106 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Sirt2 sirtuin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23502856)		 Ensembl
RGD		 PMID:23502856 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within ISO (PMID:32514138)
(PMID:29887864)		 RGD PMID:29887864 PMID:32514138 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim31 tripartite motif-containing 31 involved_in ISO (PMID:27929086) RGD PMID:27929086 NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494 		JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:36586411)		 UniProt
Ensembl
RGD		 PMID:36586411 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:13,363,504...13,366,383
Ensembl chr 3:13,363,504...13,366,474 		JBrowse link
negative regulation of non-canonical inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37962578)		 UniProt
Ensembl
RGD		 PMID:37962578 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
positive regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbp2 guanylate binding protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25774715), (PMID:25774716)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25774715 PMID:25774716 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571 		JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (PMID:25774715), (PMID:25774716) RGD PMID:25774715 PMID:25774716 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061 		JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23502856)		 Ensembl
RGD		 PMID:23502856 GO_REF:0000107 NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28943315)
(PMID:23246432)		 UniProt
RGD		 PMID:23246432 PMID:28943315 GO_REF:0000024 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080 		JBrowse link
G Btk Bruton tyrosine kinase involved_in ISO (PMID:34554188) RGD PMID:34554188 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:26173909) RGD PMID:26173909 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cd36 CD36 molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23812099)		 UniProt
Ensembl
RGD		 PMID:23812099 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:31511697) RGD PMID:31511697 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Dhx33 DEAH-box helicase 33 involved_in ISO (PMID:23871209) RGD PMID:23871209 NCBI chr10:55,708,102...55,724,618
Ensembl chr10:55,705,756...55,724,567 		JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (PMID:22461501) RGD PMID:22461501 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061 		JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:84,525,613...84,533,948
Ensembl chr 1:84,525,590...84,534,677 		JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in ISO (PMID:39173637) RGD PMID:39173637 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Lats2 large tumor suppressor kinase 2 involved_in ISO (PMID:39173637) RGD PMID:39173637 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28943315)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28943315 GO_REF:0000024 GO_REF:0000107 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mark4 microtubule affinity regulating kinase 4 involved_in ISO (PMID:28656979) RGD PMID:28656979 NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in ISO (PMID:23582325) RGD PMID:23582325 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mir21 microRNA 21 IDA RGD PMID:29084974 RGD:41404715 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:33718825)		 UniProt
RGD		 PMID:33718825 GO_REF:0000024 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nek7 NIMA-related kinase 7 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:26642356), (PMID:26814970)
(PMID:31189953), (PMID:36442502), (PMID:39173637)
GO_REF:0000033		 UniProt
Ensembl
RGD
GO_Central		 PMID:26642356 PMID:26814970 PMID:31189953 PMID:36442502 PMID:39173637 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29958799)		 UniProt
RGD		 PMID:29958799 GO_REF:0000024 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138)
GO_REF:0000107		 RGD
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:28465465)		 UniProt
RGD		 PMID:28465465 GO_REF:0000024 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkd1 protein kinase D1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28716882)		 UniProt
RGD		 PMID:28716882 GO_REF:0000024 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:27043286) RGD PMID:27043286 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Stmp1 short transmembrane mitochondrial protein 1 involved_in ISO (PMID:31836654) RGD PMID:31836654 NCBI chr 4:63,927,523...63,937,355 JBrowse link
G Tlr4 toll-like receptor 4 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23812099)		 UniProt
Ensembl
RGD		 PMID:23812099 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO (PMID:23812099) RGD PMID:23812099 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Usp50 ubiquitin specific peptidase 50 acts_upstream_of_or_within ISO (PMID:28094437) RGD PMID:28094437 NCBI chr 3:114,012,104...114,035,468
Ensembl chr 3:114,011,702...114,035,476 		JBrowse link
G Zdhhc1 zinc finger, DHHC-type containing 1 involved_in ISO (PMID:39173637) RGD PMID:39173637 NCBI chr19:33,350,533...33,375,717
Ensembl chr19:33,350,533...33,375,616 		JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in ISO (PMID:38092000) RGD PMID:38092000 NCBI chr 3:69,772,037...69,800,142
Ensembl chr 3:69,771,890...69,799,921 		JBrowse link
regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22801494)		 UniProt
RGD		 PMID:22801494 GO_REF:0000024 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Kcnk13 potassium two pore domain channel subfamily K member 13 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:35353387)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:35353387 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:119,240,825...119,345,292
Ensembl chr 6:119,242,188...119,345,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      signal transduction 7180
        regulation of signal transduction 3279
          regulation of pattern recognition receptor signaling pathway 182
            regulation of cytoplasmic pattern recognition receptor signaling pathway 123
              regulation of inflammasome-mediated signaling pathway 46
                negative regulation of inflammasome-mediated signaling pathway + 15
                positive regulation of inflammasome-mediated signaling pathway + 29
                regulation of AIM2 inflammasome complex assembly + 3
                regulation of NLRP3 inflammasome complex assembly + 43
Path 2
Term Annotations click to browse term
  biological_process 20069
    response to stimulus 10792
      response to external stimulus 2751
        response to external biotic stimulus 1863
          response to other organism 1859
            defense response to other organism 1311
              defense response to symbiont 1177
                innate immune response 1005
                  regulation of innate immune response 480
                    positive regulation of innate immune response 386
                      activation of innate immune response 314
                        innate immune response-activating signaling pathway 287
                          pattern recognition receptor signaling pathway 276
                            cytoplasmic pattern recognition receptor signaling pathway 181
                              regulation of cytoplasmic pattern recognition receptor signaling pathway 123
                                regulation of inflammasome-mediated signaling pathway 46
                                  negative regulation of inflammasome-mediated signaling pathway + 15
                                  positive regulation of inflammasome-mediated signaling pathway + 29
                                  regulation of AIM2 inflammasome complex assembly + 3
                                  regulation of NLRP3 inflammasome complex assembly + 43
paths to the root