Fbxl2 (F-box and leucine-rich repeat protein 2) - Rat Genome Database

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Gene: Fbxl2 (F-box and leucine-rich repeat protein 2) Rattus norvegicus
Analyze
Symbol: Fbxl2
Name: F-box and leucine-rich repeat protein 2
RGD ID: 1562243
Description: Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity; protein phosphatase binding activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; modulation by host of viral RNA genome replication; and negative regulation of NLRP3 inflammasome complex assembly. Predicted to act upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box/LRR-repeat protein 2; LOC363156; RGD1562243; similar to F-box and leucine-rich repeat protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28113,916,660 - 113,965,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8113,913,373 - 113,965,066 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08122,240,393 - 122,290,439 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,243,016 - 122,311,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,554,708 - 121,603,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,621,502 - 118,669,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,162,143 - 113,212,326 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15893726   PMID:21343341   PMID:23604317   PMID:26674878  


Genomics

Comparative Map Data
Fbxl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28113,916,660 - 113,965,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8113,913,373 - 113,965,066 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08122,240,393 - 122,290,439 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,243,016 - 122,311,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,554,708 - 121,603,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,621,502 - 118,669,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,162,143 - 113,212,326 (-)NCBICelera
Cytogenetic Map8q32NCBI
FBXL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38333,277,025 - 33,422,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl333,277,025 - 33,403,662 (+)EnsemblGRCh38hg38GRCh38
GRCh37333,318,517 - 33,464,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36333,293,938 - 33,403,129 (+)NCBINCBI36Build 36hg18NCBI36
Build 34333,293,937 - 33,403,121NCBI
Celera333,262,399 - 33,372,286 (+)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef333,259,441 - 33,369,309 (+)NCBIHuRef
CHM1_1333,268,994 - 33,378,729 (+)NCBICHM1_1
T2T-CHM13v2.0333,278,817 - 33,424,454 (+)NCBIT2T-CHM13v2.0
Fbxl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399113,787,625 - 113,855,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9113,792,705 - 113,875,259 (-)EnsemblGRCm39 Ensembl
GRCm389113,958,557 - 114,026,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9113,963,637 - 114,046,191 (-)EnsemblGRCm38mm10GRCm38
MGSCv379113,886,076 - 113,935,869 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369113,825,656 - 113,875,449 (-)NCBIMGSCv36mm8
Celera9113,686,095 - 113,734,801 (-)NCBICelera
Cytogenetic Map9F3NCBI
Fbxl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955421512,158 - 617,524 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955421512,197 - 617,524 (+)NCBIChiLan1.0ChiLan1.0
FBXL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1333,261,360 - 33,370,750 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0333,199,436 - 33,308,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1333,501,519 - 33,646,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl333,501,525 - 33,610,039 (+)Ensemblpanpan1.1panPan2
FBXL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,498,253 - 3,606,016 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,498,979 - 3,607,093 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,541,659 - 3,650,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,750,529 - 3,868,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl233,749,200 - 3,868,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,592,258 - 3,701,543 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,719,289 - 3,828,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,692,819 - 3,802,389 (-)NCBIUU_Cfam_GSD_1.0
Fbxl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118190,428,643 - 190,520,703 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647323,567,230 - 23,658,240 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647323,567,251 - 23,659,708 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1319,128,237 - 19,221,201 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11319,128,145 - 19,206,458 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11577,769,424 - 77,895,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1577,769,748 - 77,878,340 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604151,150,472 - 51,278,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478811,253,934 - 11,349,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478811,253,912 - 11,350,045 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxl2
137 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000033126
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat

Markers in Region
D8Got178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28113,974,178 - 113,974,319 (+)MAPPERmRatBN7.2
Rnor_6.08122,309,023 - 122,309,163NCBIRnor6.0
Rnor_5.08121,621,877 - 121,622,017UniSTSRnor5.0
RGSC_v3.48118,678,708 - 118,678,848RGDRGSC3.4
RGSC_v3.48118,678,709 - 118,678,849UniSTSRGSC3.4
RGSC_v3.18118,698,163 - 118,698,303RGD
Celera8113,221,389 - 113,221,529UniSTS
RH 3.4 Map81202.1UniSTS
RH 3.4 Map81202.1RGD
RH 2.0 Map8955.6RGD
Cytogenetic Map8q32UniSTS
BF412611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28113,922,884 - 113,923,106 (+)MAPPERmRatBN7.2
Rnor_6.08122,248,627 - 122,248,848NCBIRnor6.0
Rnor_5.08121,562,157 - 121,562,378UniSTSRnor5.0
RGSC_v3.48118,626,927 - 118,627,148UniSTSRGSC3.4
Celera8113,170,375 - 113,170,596UniSTS
RH 3.4 Map81198.6UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 50 1
Low 3 42 30 14 19 14 8 8 24 31 40 11 8
Below cutoff 1 21 21 21 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033126   ⟹   ENSRNOP00000033447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8113,913,373 - 113,965,066 (-)Ensembl
Rnor_6.0 Ensembl8122,243,016 - 122,311,431 (-)Ensembl
RefSeq Acc Id: XM_039082672   ⟹   XP_038938600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28113,916,660 - 113,965,061 (-)NCBI
RefSeq Acc Id: XM_039082673   ⟹   XP_038938601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28113,922,205 - 113,965,061 (-)NCBI
RefSeq Acc Id: XM_039082674   ⟹   XP_038938602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28113,922,205 - 113,965,061 (-)NCBI
RefSeq Acc Id: XM_343495   ⟹   XP_343496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28113,916,660 - 113,965,137 (-)NCBI
Rnor_6.08122,240,393 - 122,290,439 (-)NCBI
Rnor_5.08121,554,708 - 121,603,927 (-)NCBI
RGSC_v3.48118,621,502 - 118,669,052 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_038938600 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938601 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938602 (Get FASTA)   NCBI Sequence Viewer  
  XP_343496 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76997 (Get FASTA)   NCBI Sequence Viewer  
  EDL76998 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_343496   ⟸   XM_343495
- Peptide Label: isoform X2
- UniProtKB: F1M768 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033447   ⟸   ENSRNOT00000033126
RefSeq Acc Id: XP_038938600   ⟸   XM_039082672
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038938601   ⟸   XM_039082673
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938602   ⟸   XM_039082674
- Peptide Label: isoform X4
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M768-F1-model_v2 AlphaFold F1M768 1-438 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562243 AgrOrtholog
BioCyc Gene G2FUF-28935 BioCyc
Ensembl Genes ENSRNOG00000027099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033447 ENTREZGENE
  ENSRNOP00000033447.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033126 ENTREZGENE
  ENSRNOT00000033126.7 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
KEGG Report rno:363156 UniProtKB/TrEMBL
NCBI Gene 363156 ENTREZGENE
PANTHER F-BOX/LRR-REPEAT PROTEIN 2 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
PhenoGen Fbxl2 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
  LRR_CC UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt F1M768 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Fbxl2  F-box and leucine-rich repeat protein 2  RGD1562243_predicted  similar to F-box and leucine-rich repeat protein 2 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562243_predicted  similar to F-box and leucine-rich repeat protein 2 (predicted)  LOC363156  similar to F-box and leucine-rich repeat protein 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363156  similar to F-box and leucine-rich repeat protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL