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ONTOLOGY REPORT - ANNOTATIONS

Term:cytosolic pattern recognition receptor signaling pathway
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Accession:GO:0002753 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a ligand from another organism to a cytosolic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Comment:This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has been activated. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
Synonyms:exact_synonym: cytoplasmic PAMP receptor signaling pathway;   cytoplasmic PRR signaling pathway;   cytoplasmic pathogen receptor signaling pathway;   cytoplasmic pattern recognition receptor signaling pathway;   cytoplasmic pattern recognition receptor signalling pathway
 narrow_synonym: cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway;   cytoplasmic pattern recognition receptor signaling pathway in response to virus;   cytoplasmic pattern recognition receptor signalling pathway in response to virus;   virus-induced cytoplasmic pattern recognition receptor signaling pathway
 alt_id: GO:0039528


show annotations for term's descendants           Sort by:
 
cytosolic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpk1 alpha-kinase 1 involved_in ISO
IBA		 (PMID:28222186), (PMID:28877472), (PMID:30111836)
PMID:21873635
(MGI:6196443|PMID:30111836)		 RGD PMID:28222186 PMID:28877472 PMID:30111836 PMID:21873635 MGI:6196443, RGD:13792537 NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (PMID:19211564) RGD PMID:19211564 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain involved_in ISO
ISS
IBA		 (PMID:26068852), (PMID:28222186), (PMID:28877472), (PMID:30111836)
GO_REF:0000024
PMID:21873635		 RGD
UniProt		 PMID:26068852 PMID:28222186 PMID:28877472 PMID:30111836 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841 		JBrowse link
MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 involved_in ISO (PMID:17600090), (PMID:33727702)
(PMID:17600090), (PMID:19211564), (PMID:33727702)		 RGD PMID:17600090 PMID:19211564 PMID:33727702 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA		 (PMID:30078389)
GO_REF:0000107		 RGD
Ensembl		 PMID:30078389 GO_REF:0000107 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISO
ISS		 (PMID:19164550)
GO_REF:0000024		 RGD
UniProt		 PMID:19164550 GO_REF:0000024 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (PMID:21187438) RGD PMID:21187438 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO (PMID:25865883) RGD PMID:25865883 NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343 		JBrowse link
G Tkfc triokinase and FMN cyclase involved_in ISS
ISO		 GO_REF:0000024
(PMID:17600090)		 UniProt
RGD		 PMID:17600090 GO_REF:0000024 NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:3777503|PMID:18342009) RGD PMID:18342009 MGI:3777503 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbin erbb2 interacting protein involved_in ISO (PMID:16203728)
(MGI:5640951|PMID:16203728)		 RGD PMID:16203728 MGI:5640951 NCBI chr 2:34,926,962...35,028,440
Ensembl chr 2:34,928,863...35,027,852 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO		 PMID:21873635
(MGI:5640942|PMID:23991106)
(PMID:23991106)		 RGD PMID:23991106 PMID:21873635 MGI:5640942, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:3777503|PMID:18342009) RGD PMID:18342009 MGI:3777503 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISO
ISS		 (PMID:19164550)
GO_REF:0000024		 RGD
UniProt		 PMID:19164550 GO_REF:0000024 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (PMID:18411269), (PMID:21187438)
(MGI:3836702|PMID:17475874)		 RGD PMID:17475874 PMID:18411269 PMID:21187438 MGI:3836702 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Gpatch3 G patch domain containing 3 involved_in ISO
IBA		 (PMID:28414768)
PMID:21873635		 RGD PMID:28414768 PMID:21873635 RGD:13792537 NCBI chr 5:145,798,069...145,809,250
Ensembl chr 5:145,800,111...145,809,250 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5141085 (MGI:5050761|PMID:21703540)		 Ensembl
RGD		 PMID:21703540 GO_REF:0000107 MGI:5050761 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISO
IEA
ISS		 (PMID:26471729)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26471729 GO_REF:0000024 GO_REF:0000107 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Rnf125 ring finger protein 125 involved_in ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044 PMID:26471729 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Sec14l1 SEC14-like lipid binding 1 involved_in ISO
IBA		 (PMID:23843640)
PMID:21873635		 RGD PMID:23843640 PMID:21873635 RGD:13792537 NCBI chr10:102,319,920...102,367,070
Ensembl chr10:102,319,920...102,367,068 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
ISS		 (PMID:26471729)
GO_REF:0000024		 RGD
UniProt		 PMID:26471729 GO_REF:0000024 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) RGD PMID:19865078 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:15474016) RGD PMID:15474016 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5619743|PMID:21695056)		 Ensembl
RGD		 PMID:21695056 GO_REF:0000107 MGI:5619743 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gramd4 GRAM domain containing 4 involved_in IBA
ISO		 PMID:21873635
(MGI:6274965|PMID:25917084)		 RGD PMID:25917084 PMID:21873635 MGI:6274965, RGD:13792537 NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO (PMID:26231120) RGD PMID:26231120 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in ISO (MGI:4355098|PMID:19587007) RGD PMID:19587007 MGI:4355098 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tspan6 tetraspanin 6 involved_in ISO (PMID:22908223) RGD PMID:22908223 NCBI chr  X:97,092,394...97,099,659
Ensembl chr  X:97,092,388...97,099,309 		JBrowse link
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia NFKB inhibitor alpha acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2660793 (MGI:2176422|PMID:11894098) RGD PMID:11894098 MGI:2176422 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:3775161|PMID:18261938)
GO_REF:0000107		 RGD
Ensembl		 PMID:18261938 GO_REF:0000107 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inava innate immunity activator involved_in ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lacc1 laccase domain containing 1 involved_in ISO (PMID:31875558) RGD PMID:31875558 NCBI chr15:52,390,267...52,407,630
Ensembl chr15:52,395,183...52,407,545 		JBrowse link
G Nfkbia NFKB inhibitor alpha acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO (MGI:5562512|PMID:23892723)
(PMID:12527755)
(PMID:23806334)		 RGD PMID:12527755 PMID:23806334 PMID:23892723 MGI:5562512 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity involved_in ISO (PMID:23806334) RGD PMID:23806334 NCBI chr 2:78,290,437...78,316,633
Ensembl chr 2:78,290,959...78,316,422 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:12527755) RGD PMID:12527755 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:23806334)
MGI:2660793 (MGI:2176422|PMID:11894098)		 RGD PMID:11894098 PMID:23806334 MGI:2176422 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:3775161|PMID:18261938)
GO_REF:0000107		 RGD
Ensembl		 PMID:18261938 GO_REF:0000107 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in ISO (PMID:22328336) RGD PMID:22328336 NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Ddx60 DEXD/H-box helicase 60 involved_in ISO (PMID:21791617) RGD PMID:21791617 NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (MGI:4421606|PMID:20080593) RGD PMID:20080593 MGI:4421606 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:20368735) RGD PMID:20368735 NCBI chr 1:159,151,417...159,155,192
Ensembl chr 1:159,151,432...159,155,192 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6278628|PMID:21277849), (MGI:6450424|PMID:19570976)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:19570976 PMID:21277849 GO_REF:0000024 GO_REF:0000107 MGI:6278628 MGI:6450424 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 involved_in ISO (PMID:28539433) RGD PMID:28539433 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3775161|PMID:18261938)		 Ensembl
RGD		 PMID:18261938 GO_REF:0000107 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (MGI:5562512|PMID:23892723) RGD PMID:23892723 MGI:5562512 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Slc15a3 solute carrier family 15 member 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5571205|PMID:24695226)		 UniProt
RGD		 PMID:24695226 GO_REF:0000024 MGI:5571205 NCBI chr 1:207,492,365...207,507,158
Ensembl chr 1:207,492,365...207,507,157 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5571205|PMID:24695226)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24695226 GO_REF:0000024 GO_REF:0000107 MGI:5571205 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3775161|PMID:18261938)		 Ensembl
RGD		 PMID:18261938 GO_REF:0000107 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in ISO (PMID:22328336) RGD PMID:22328336 NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Ddx60 DEXD/H-box helicase 60 involved_in ISO (PMID:21791617) RGD PMID:21791617 NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (MGI:4421606|PMID:20080593) RGD PMID:20080593 MGI:4421606 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:20368735) RGD PMID:20368735 NCBI chr 1:159,151,417...159,155,192
Ensembl chr 1:159,151,432...159,155,192 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like involved_in ISO (PMID:25925578) RGD PMID:25925578 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641 		JBrowse link
G Pum1 pumilio RNA-binding family member 1 involved_in ISO (PMID:25340845) RGD PMID:25340845 NCBI chr 5:142,836,933...142,954,331
Ensembl chr 5:142,837,127...142,954,039 		JBrowse link
G Pum2 pumilio RNA-binding family member 2 involved_in ISO (PMID:25340845) RGD PMID:25340845 NCBI chr 6:31,462,879...31,542,976
Ensembl chr 6:31,462,872...31,542,976 		JBrowse link
G Trim15 tripartite motif containing 15 involved_in ISO (PMID:23077300) RGD PMID:23077300 NCBI chr20:1,700,905...1,710,249
Ensembl chr20:1,700,905...1,710,249 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 involved_in ISO
IEA		 (PMID:24399297)
GO_REF:0000107		 RGD
Ensembl		 PMID:24399297 GO_REF:0000107 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 involved_in ISO (PMID:21102435) RGD PMID:21102435 NCBI chr 4:67,012,151...67,062,406
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 involved_in ISO
IBA		 (PMID:30193849)
PMID:21873635		 RGD PMID:30193849 PMID:21873635 RGD:13792537 NCBI chr 3:140,872,460...140,875,851
Ensembl chr 3:140,872,460...140,882,408 		JBrowse link
positive regulation of toll-like receptor 13 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Treml4 triggering receptor expressed on myeloid cells-like 4 involved_in ISO (MGI:5775261|PMID:25848864) RGD PMID:25848864 MGI:5775261 NCBI chr 9:12,718,968...12,743,879
Ensembl chr 9:12,721,815...12,743,253 		JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) RGD PMID:19865078 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Flot1 flotillin 1 involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:4361448 (MGI:4359971|PMID:19734906) RGD PMID:19734906 MGI:4359971 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO		 PMID:21873635
(MGI:5562517|PMID:23871208)
(PMID:23871208)		 RGD PMID:23871208 PMID:21873635 MGI:5562517, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (MGI:4943396|PMID:17322885) RGD PMID:17322885 MGI:4943396 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 involved_in ISO
IBA		 (PMID:25736436)
PMID:21873635
(MGI:5688815|PMID:25736436)		 RGD PMID:25736436 PMID:21873635 MGI:5688815, RGD:13792537 NCBI chr 9:81,034,852...81,092,823
Ensembl chr 9:81,034,849...81,092,775 		JBrowse link
positive regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:30341167) RGD PMID:30341167 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO		 PMID:21873635
(MGI:5562517|PMID:23871208)		 RGD PMID:23871208 PMID:21873635 MGI:5562517, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:4943343|PMID:21435586)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21435586 GO_REF:0000024 GO_REF:0000107 MGI:4943343 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:4848237|PMID:21045126), (MGI:6357091|PMID:25238095)
GO_REF:0000024
(PMID:25238095), (PMID:32433612)		 Ensembl
RGD
UniProt		 PMID:21045126 PMID:25238095 PMID:32433612 GO_REF:0000024 GO_REF:0000107 MGI:4848237 MGI:6357091 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO (PMID:32433612) RGD PMID:32433612 NCBI chr  X:50,403,962...50,423,141
Ensembl chr  X:50,361,248...50,423,269 		JBrowse link
G Treml4 triggering receptor expressed on myeloid cells-like 4 involved_in ISO
IBA		 (PMID:25848864)
(MGI:5775261|PMID:25848864)
PMID:21873635		 RGD PMID:25848864 PMID:21873635 MGI:5775261, RGD:13792537 NCBI chr 9:12,718,968...12,743,879
Ensembl chr 9:12,721,815...12,743,253 		JBrowse link
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:30341167) RGD PMID:30341167 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:32433612)		 Ensembl
UniProt
RGD		 PMID:32433612 GO_REF:0000024 GO_REF:0000107 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO (PMID:32433612) RGD PMID:32433612 NCBI chr  X:50,403,962...50,423,141
Ensembl chr  X:50,361,248...50,423,269 		JBrowse link
positive regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO		 PMID:21873635
(MGI:5562517|PMID:23871208)		 RGD PMID:23871208 PMID:21873635 MGI:5562517, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:4943343|PMID:21435586)		 UniProt
Ensembl
RGD		 PMID:21435586 GO_REF:0000024 GO_REF:0000107 MGI:4943343 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G Rtn4 reticulon 4 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6274965|PMID:25917084)		 UniProt
Ensembl
RGD		 PMID:25917084 GO_REF:0000024 GO_REF:0000107 MGI:6274965 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO
ISS
IEA		 (PMID:25238095)
GO_REF:0000024
(MGI:4848237|PMID:21045126), (MGI:6278628|PMID:21277849), (MGI:6357091|PMID:25238095)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:21045126 PMID:21277849 PMID:25238095 GO_REF:0000024 GO_REF:0000107 MGI:4848237 MGI:6278628 MGI:6357091 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (MGI:3828189|PMID:18931679) RGD PMID:18931679 MGI:3828189 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Treml4 triggering receptor expressed on myeloid cells-like 4 involved_in ISO (MGI:5775261|PMID:25848864) RGD PMID:25848864 MGI:5775261 NCBI chr 9:12,718,968...12,743,879
Ensembl chr 9:12,721,815...12,743,253 		JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (MGI:5562512|PMID:23892723) RGD PMID:23892723 MGI:5562512 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
regulation of nucleotide-binding oligomerization domain containing signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a2 solute carrier family 15 member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6192142|PMID:29784761)		 UniProt
RGD		 PMID:29784761 GO_REF:0000024 MGI:6192142 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6192142|PMID:29784761)		 UniProt
RGD		 PMID:29784761 GO_REF:0000024 MGI:6192142 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:27824081) RGD PMID:27824081 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 NOT|involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756 		JBrowse link
regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:23857366) RGD PMID:23857366 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir708 microRNA 708 involved_in ISO (PMID:31599428) RGD PMID:31599428 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963 		JBrowse link
RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpb caseinolytic mitochondrial matrix peptidase chaperone subunit B involved_in ISO (PMID:31522117) RGD PMID:31522117 NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788 		JBrowse link
G Ddx58 DEXD/H-box helicase 58 involved_in ISO (PMID:19211564), (PMID:28469175) RGD PMID:19211564 PMID:28469175 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor acts_upstream_of_or_within ISO MGI:2442858|MGI:2444773 (MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:5432265 NCBI chr 1:86,964,800...87,009,325
Ensembl chr 1:86,964,828...87,009,276 		JBrowse link
G Mavs mitochondrial antiviral signaling protein acts_upstream_of_or_within ISO MGI:1914320 (MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:5432265 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA		 (PMID:30078389)
GO_REF:0000107		 RGD
Ensembl		 PMID:30078389 GO_REF:0000107 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:31522117) RGD PMID:31522117 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Phb2 prohibitin 2 involved_in ISO
IEA		 (PMID:31522117)
GO_REF:0000107		 RGD
Ensembl		 PMID:31522117 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Rnf135 ring finger protein 135 involved_in ISO
ISS		 (PMID:23950712), (PMID:28469175), (PMID:31006531)
GO_REF:0000024
UniProtKB:Q8IUD6 (MGI:6152590|PMID:21147464), (MGI:6377978|PMID:28469175)		 RGD
UniProt		 PMID:21147464 PMID:23950712 PMID:28469175 PMID:31006531 GO_REF:0000024 MGI:6152590 MGI:6377978 NCBI chr10:65,170,560...65,189,791
Ensembl chr10:65,170,560...65,262,804 		JBrowse link
G Trim25 tripartite motif-containing 25 NOT|involved_in ISO (PMID:31006531) RGD PMID:31006531 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257 		JBrowse link
toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule involved_in ISO (MGI:5645190|PMID:25158758) RGD PMID:25158758 MGI:5645190 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Colec12 collectin sub-family member 12 involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Lgals9 galectin 9 involved_in IMP PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30078389) RGD PMID:30078389 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Rftn1 raftlin lipid raft linker 1 acts_upstream_of_or_within ISO (PMID:21266579) RGD PMID:21266579 NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084 		JBrowse link
G Scara3 scavenger receptor class A, member 3 NOT|involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr15:40,139,873...40,172,866
Ensembl chr15:40,140,161...40,172,894 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr10:55,507,593...55,528,288
Ensembl chr10:55,507,519...55,528,171 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tnf tumor necrosis factor involved_in IMP PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IBA
ISO		 PMID:21873635
(MGI:3656197|PMID:16633345)		 RGD PMID:16633345 PMID:21873635 MGI:3656197, RGD:13792537 NCBI chr14:76,228,283...76,246,609
Ensembl chr14:76,228,371...76,275,265 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IBA
ISO		 PMID:21873635
(MGI:3615690|PMID:16415873)
(PMID:18082565)		 RGD PMID:16415873 PMID:18082565 PMID:21873635 MGI:3615690, RGD:13792537 NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338 		JBrowse link
toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305504|PMID:22187458) RGD PMID:22187458 MGI:5305504 NCBI chr 1:240,090,859...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr10:55,507,593...55,528,288
Ensembl chr10:55,507,519...55,528,171 		JBrowse link
G Tlr7 toll-like receptor 7 involved_in ISO
IEA		 (MGI:3042320|PMID:14976261)
GO_REF:0000002		 RGD
InterPro		 PMID:14976261 GO_REF:0000002 MGI:3042320 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IBA
ISO		 PMID:21873635
(MGI:3615690|PMID:16415873)
(PMID:19006693)		 RGD PMID:16415873 PMID:19006693 PMID:21873635 MGI:3615690, RGD:13792537 NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338 		JBrowse link
toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 MYD88, innate immune signal transduction adaptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:33718825)		 UniProt
RGD		 PMID:33718825 GO_REF:0000024 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Tlr8 toll-like receptor 8 involved_in ISO (PMID:24942581), (PMID:33718825) RGD PMID:24942581 PMID:33718825 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epg5 ectopic P-granules 5 autophagy tethering factor acts_upstream_of_positive_effect ISO (PMID:29130391) RGD PMID:29130391 NCBI chr18:71,403,990...71,502,079
Ensembl chr18:71,404,010...71,501,502 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (MGI:5486235|PMID:23372731)
GO_REF:0000107		 RGD
Ensembl		 PMID:23372731 GO_REF:0000107 MGI:5486235 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305503|PMID:22187460), (MGI:5305504|PMID:22187458) RGD PMID:22187458 PMID:22187460 MGI:5305503 MGI:5305504 NCBI chr 1:240,090,859...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in ISO (MGI:3656197|PMID:16633345) RGD PMID:16633345 MGI:3656197 NCBI chr14:76,228,283...76,246,609
Ensembl chr14:76,228,371...76,275,265 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IBA
ISO		 PMID:21873635
(MGI:3615690|PMID:16415873)
(PMID:19006693)		 RGD PMID:16415873 PMID:19006693 PMID:21873635 MGI:3615690, RGD:13792537 NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      signal transduction 7110
        intracellular receptor signaling pathway 295
          cytosolic pattern recognition receptor signaling pathway 90
            MDA-5 signaling pathway + 9
            RIG-I signaling pathway + 28
            cGAS/STING signaling pathway 0
            endolysosomal toll-like receptor signaling pathway + 39
            endosomal pattern recognition receptor signaling pathway 0
            negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 19
            nucleotide-binding oligomerization domain containing signaling pathway + 19
            regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 52
Path 2
Term Annotations click to browse term
  biological_process 20099
    response to stimulus 10542
      response to external stimulus 3276
        response to external biotic stimulus 1760
          response to other organism 1756
            defense response to other organism 1210
              innate immune response 897
                regulation of innate immune response 372
                  positive regulation of innate immune response 295
                    activation of innate immune response 223
                      innate immune response-activating signaling pathway 196
                        pattern recognition receptor signaling pathway 183
                          cytosolic pattern recognition receptor signaling pathway 90
                            MDA-5 signaling pathway + 9
                            RIG-I signaling pathway + 28
                            cGAS/STING signaling pathway 0
                            endolysosomal toll-like receptor signaling pathway + 39
                            endosomal pattern recognition receptor signaling pathway 0
                            negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 19
                            nucleotide-binding oligomerization domain containing signaling pathway + 19
                            regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 52
paths to the root