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ONTOLOGY REPORT - ANNOTATIONS

Term:scaffold protein binding
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Accession:GO:0097110 term browser browse the term
Definition:Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.


show annotations for term's descendants           Sort by:
scaffold protein binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY5 adenylate cyclase 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090 		JBrowse link
G ADCY6 adenylate cyclase 6 enables ISO (PMID:20164376) MGI PMID:20164376 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 enables IPI (PMID:10939335) SynGO-UCL PMID:10939335 NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503 		JBrowse link
G ATG4B autophagy related 4B cysteine peptidase enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr 2:241,637,693...241,673,857
Ensembl chr 2:241,637,213...241,673,857 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 enables ISS BHF-UCL GO_REF:0000024 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,832...203,744,081 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 enables ISO
IEA		 RGD
Ensembl		 PMID:12421375 PMID:15673667 PMID:15758177 GO_REF:0000107 RGD:11576289 RGD:9684984 RGD:9684988 NCBI chr17:81,035,151...81,117,434
Ensembl chr17:81,035,122...81,117,434 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase enables IPI (PMID:18567582) BHF-UCL PMID:18567582 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G enables IPI (PMID:21084288) BHF-UCL PMID:21084288 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H enables IPI (PMID:21084288) BHF-UCL PMID:21084288 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G CASP1 caspase 1 ISO RGD PMID:19416975 RGD:5491011 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP4 caspase 4 ISO RGD PMID:19416975 RGD:5491011 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP8 caspase 8 enables IPI (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAV2 caveolin 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541 		JBrowse link
G CD163 CD163 molecule enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr12:7,470,811...7,503,777
Ensembl chr12:7,470,811...7,503,893 		JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone enables IPI (PMID:10409742) UniProt PMID:10409742 NCBI chr19:10,391,133...10,403,542
Ensembl chr19:10,391,133...10,420,121 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:22593058 RGD:7205692 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex enables IDA (PMID:23776175) MGI PMID:23776175 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CIT citron rho-interacting serine/threonine kinase enables IDA
ISO		 (PMID:17474715) BHF-UCL
RGD		 PMID:9870942 PMID:17474715 RGD:70684 NCBI chr12:119,685,791...119,877,320
Ensembl chr12:119,685,791...119,877,320 		JBrowse link
G CRIPT CXXC repeat containing interactor of PDZ3 domain enables IDA (PMID:17474715) BHF-UCL PMID:17474715 NCBI chr 2:46,617,215...46,630,176
Ensembl chr 2:46,616,416...46,630,176 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein enables ISO
IEA		 RGD
Ensembl		 PMID:20623582 GO_REF:0000107 RGD:11568073 NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 enables ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836 		JBrowse link
G DLGAP3 DLG associated protein 3 enables ISO PMID:10433269 BHF-UCL PMID:10433269 RGD:8554380 NCBI chr 1:34,865,436...34,929,650
Ensembl chr 1:34,865,436...34,929,650 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:170,282,206...170,291,078
Ensembl chr 6:170,282,206...170,306,565 		JBrowse link
G DSP desmoplakin enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr 6:7,541,671...7,586,714
Ensembl chr 6:7,541,326...7,586,717 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 enables ISO
IEA		 RGD
Ensembl		 PMID:12097491 GO_REF:0000107 RGD:628355 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493 		JBrowse link
G DYNLL2 dynein light chain LC8-type 2 ISO RGD PMID:12097491 RGD:628355 NCBI chr17:58,083,419...58,095,542
Ensembl chr17:58,083,419...58,095,542 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G GIT1 GIT ArfGAP 1 ISO RGD PMID:12629171 RGD:152995492 NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054 		JBrowse link
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 enables ISO
IEA		 RGD
Ensembl		 PMID:14597197 PMID:23460828 GO_REF:0000107 RGD:152975667 RGD:152995495 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO RGD PMID:10414981 RGD:632958 NCBI chr 4:157,220,120...157,366,075
Ensembl chr 4:157,204,182...157,387,146 		JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 enables ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:92,303,966...93,810,456
Ensembl chr 4:92,303,966...93,810,157 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO Dlg4 species unclear; MMO:0000683 RGD PMID:12597860 RGD:152995391 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 enables ISO
IEA		 Dlg4 species unclear;MMO:0000683 RGD
Ensembl		 PMID:12597860 GO_REF:0000107 RGD:152995391 NCBI chr 6:101,393,708...102,070,083
Ensembl chr 6:100,962,701...102,081,622 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A enables ISO PMID:20847060 BHF-UCL
RGD		 PMID:20847060 PMID:22375001 RGD:401950481 RGD:8554370 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:17270176 RGD:13432036 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:28162981 RGD:13513989 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 enables IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613 		JBrowse link
G GRM3 glutamate metabotropic receptor 3 enables ISS ARUK-UCL GO_REF:0000024 NCBI chr 7:86,643,909...86,864,879
Ensembl chr 7:86,643,909...86,864,879 		JBrowse link
G HOMER1 homer scaffold protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 enables IPI (PMID:10409742) UniProt PMID:10409742 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta enables IDA (PMID:23776175) MGI PMID:23776175 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer enables IPI (PMID:31145836) ARUK-UCL PMID:31145836 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 enables IPI (PMID:11782428) UniProt PMID:11782428 NCBI chr12:26,335,352...26,833,194
Ensembl chr12:26,335,352...26,833,194 		JBrowse link
G KARS1 lysyl-tRNA synthetase 1 enables ISO (MGI:3055639|PMID:12060739) CAFA PMID:12060739 MGI:3055639 NCBI chr16:75,627,724...75,647,665
Ensembl chr16:75,627,474...75,648,643 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 enables IPI (PMID:18281375)
(PMID:12970345)		 BHF-UCL PMID:12970345 PMID:18281375 NCBI chr12:5,043,879...5,046,788
Ensembl chr12:5,043,879...5,046,788 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 enables IPI (PMID:18923542) BHF-UCL PMID:18923542 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 enables IPI (PMID:11799244), (PMID:16002409), (PMID:18093912) BHF-UCL PMID:11799244 PMID:16002409 PMID:18093912 NCBI chr11:2,445,008...2,849,105
Ensembl chr11:2,444,654...2,849,105 		JBrowse link
G KIF1B kinesin family member 1B ISO RGD PMID:12097473 RGD:8553481 NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603 		JBrowse link
G KIF5A kinesin family member 5A ISO Disc1 RGD PMID:17202468 RGD:4107038 NCBI chr12:57,550,044...57,586,633
Ensembl chr12:57,546,026...57,586,633 		JBrowse link
G KRT15 keratin 15 enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr17:41,513,745...41,518,890
Ensembl chr17:41,513,745...41,522,529 		JBrowse link
G KRT18 keratin 18 enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906 		JBrowse link
G KRT5 keratin 5 enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr12:52,514,575...52,520,394
Ensembl chr12:52,514,575...52,520,530 		JBrowse link
G KRT8 keratin 8 enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954 		JBrowse link
G LRP4 LDL receptor related protein 4 enables ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:46,856,717...46,918,550
Ensembl chr11:46,856,717...46,918,642 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr 8:55,879,835...56,014,169
Ensembl chr 8:55,879,835...56,014,169 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 enables IPI (PMID:10409742) UniProt PMID:10409742 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 enables IPI (PMID:10409742)
(PMID:21615688)		 UniProt PMID:10409742 PMID:21615688 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 enables IDA (PMID:23776175) MGI PMID:23776175 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 enables ISO PMID:20455999 BHF-UCL PMID:20455999 RGD:10047313 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MYH9 myosin heavy chain 9 ISO RGD PMID:21598299 RGD:12798522 NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,280...36,388,010 		JBrowse link
G NCK2 NCK adaptor protein 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274 		JBrowse link
G NLGN1 neuroligin 1 enables IDA (PMID:17474715) BHF-UCL PMID:17474715 NCBI chr 3:173,395,952...174,294,372
Ensembl chr 3:173,396,284...174,294,372 		JBrowse link
G NLGN3 neuroligin 3 enables IPI (PMID:17292328) BHF-UCL PMID:17292328 NCBI chr  X:71,144,841...71,175,307
Ensembl chr  X:71,144,821...71,175,255 		JBrowse link
G NLGN4X neuroligin 4 X-linked enables IPI (PMID:11368788)
(PMID:17292328)		 BHF-UCL PMID:11368788 PMID:17292328 NCBI chr  X:5,890,042...6,228,867
Ensembl chr  X:5,840,637...6,228,867 		JBrowse link
G NLGN4Y neuroligin 4 Y-linked enables IPI (PMID:17292328) BHF-UCL PMID:17292328 NCBI chr  Y:14,522,616...14,845,654
Ensembl chr  Y:14,522,573...14,845,654 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 ISO RGD PMID:19416975 RGD:5491011 NCBI chr17:5,501,396...5,584,509
Ensembl chr17:5,499,415...5,619,424 		JBrowse link
G NOS1 nitric oxide synthase 1 enables ISS BHF-UCL GO_REF:0000024 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NOS3 nitric oxide synthase 3 enables ISO
IEA		 RGD
Ensembl		 PMID:12566108 PMID:15007069 GO_REF:0000107 RGD:1599542 RGD:7794688 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G P2RX7 purinergic receptor P2X 7 ISO RGD PMID:19416975 RGD:5491011 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032 		JBrowse link
G P2RY1 purinergic receptor P2Y1 enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439 		JBrowse link
G PANX1 pannexin 1 enables ISO
IEA		 RGD
Ensembl		 PMID:19416975 GO_REF:0000107 RGD:5491011 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PARK7 Parkinsonism associated deglycase enables IPI (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G PDE4D phosphodiesterase 4D enables IPI (PMID:20819076)
(PMID:15182229)		 BHF-UCL PMID:15182229 PMID:20819076 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G PHF6 PHD finger protein 6 enables IPI (PMID:22720776) UniProt PMID:22720776 NCBI chr  X:134,373,312...134,428,790
Ensembl chr  X:134,373,288...134,428,791 		JBrowse link
G PLCG2 phospholipase C gamma 2 enables IPI (PMID:23555801)
(PMID:11606584)		 ARUK-UCL PMID:11606584 PMID:23555801 NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,779,279...81,962,685 		JBrowse link
G PSAP prosaposin enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,298...71,851,251 		JBrowse link
G RYR2 ryanodine receptor 2 enables ISO PMID:11590243 BHF-UCL PMID:11590243 RGD:1599255 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 enables IPI (PMID:17060380) BHF-UCL PMID:17060380 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:50,659,255...50,719,802
Ensembl chr19:50,659,255...50,719,802 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr22:50,672,823...50,733,212
Ensembl chr22:50,674,408...50,733,212 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase enables IPI
IEA		 (PMID:25006397) BHF-UCL
Ensembl		 PMID:25006397 GO_REF:0000107 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SYK spleen associated tyrosine kinase enables IPI (PMID:11606584) ARUK-UCL PMID:11606584 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549 		JBrowse link
G TCOF1 treacle ribosome biogenesis factor 1 enables IPI
IEA
IBA		 (PMID:23203802) CAFA
TreeGrafter
GO_Central		 PMID:23203802 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:150,357,697...150,400,293
Ensembl chr 5:150,357,629...150,400,308 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 enables IPI (PMID:11602640) BHF-UCL PMID:11602640 NCBI chr 6:41,267,385...41,286,682
Ensembl chr 6:41,267,926...41,286,682 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 enables IPI (PMID:11602640) BHF-UCL PMID:11602640 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
G UBTF upstream binding transcription factor enables IPI (PMID:23203802) CAFA PMID:23203802 NCBI chr17:44,205,040...44,221,304
Ensembl chr17:44,205,033...44,221,626 		JBrowse link
G VIM vimentin enables IPI (PMID:10852826) BHF-UCL PMID:10852826 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G XIAP X-linked inhibitor of apoptosis ISO RGD PMID:19416975 RGD:5491011 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 enables IPI (PMID:23555801) ARUK-UCL PMID:23555801 NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon enables IPI (PMID:10409742) UniProt PMID:10409742 NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19489
    binding 17887
      protein binding 15415
        scaffold protein binding 91
paths to the root