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Gene: DSP (desmoplakin) Homo sapiens
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Symbol: DSP
Name: desmoplakin
Description: Exhibits protein kinase C binding activity and scaffold protein binding activity. Involved in several processes, including epithelial cell-cell adhesion; keratinocyte differentiation; and regulation of heart contraction. Localizes to cornified envelope and intercalated disc. Predicted to colocalize with intermediate filament. Implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Biomarker of hypertrophic cardiomyopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; desmoplakin I; desmoplakin II; DP; DPI; DPII
Orthologs:
Mus musculus (house mouse) : Dsp (desmoplakin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dsp (desmoplakin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dsp (desmoplakin)
Pan paniscus (bonobo/pygmy chimpanzee) : DSP (desmoplakin)
Canis lupus familiaris (dog) : DSP (desmoplakin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dsp (desmoplakin)
Sus scrofa (pig) : DSP (desmoplakin)
Chlorocebus sabaeus (African green monkey) : DSP (desmoplakin)
Heterocephalus glaber (naked mole-rat) : Dsp (desmoplakin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl67,541,617 - 7,586,714 (+)EnsemblGRCh38hg38GRCh38
GRCh3867,541,671 - 7,586,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3767,541,808 - 7,586,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,486,869 - 7,531,945 (+)NCBINCBI36hg18NCBI36
Build 3467,486,868 - 7,531,945NCBI
Celera68,771,623 - 8,816,711 (+)NCBI
Cytogenetic Map6p24.3NCBI
HuRef67,419,476 - 7,464,417 (+)NCBIHuRef
CHM1_167,543,961 - 7,589,110 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model