RGD Reference Report - Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. - Rat Genome Database

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Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.

Authors: Hirbec, Hélène  Francis, Joanna C  Lauri, Sari E  Braithwaite, Steven P  Coussen, Françoise  Mulle, Christophe  Dev, Kumlesh K  Coutinho, Victoria  Meyer, Guido  Isaac, John T R  Collingridge, Graham L  Henley, Jeremy M 
Citation: Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
RGD ID: 152995391
Pubmed: PMID:12597860   (View Abstract at PubMed)
PMCID: PMC3314502   (View Article at PubMed Central)
DOI: DOI:10.1016/s0896-6273(02)01191-1   (Journal Full-text)

We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In addition, PKC alpha can phosphorylate ct-GluR5(2b) at residues S880 and S886, and PKC activity is required to maintain KAR-mediated synaptic responses. We propose that PICK1 targets PKC alpha to phosphorylate KARs, causing their stabilization at the synapse by an interaction with GRIP. Importantly, this mechanism is not involved in the constitutive recycling of AMPA receptors since blockade of PDZ interactions can simultaneously increase AMPAR- and decrease KAR-mediated synaptic transmission at the same population of synapses.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pick1Rationotropic glutamate receptor binding  IPIGrik1 (Rattus norvegicus)MMO:0000683RGD 
Pick1Rationotropic glutamate receptor binding  IPIGrik2 (Rattus norvegicus)MMO:0000683RGD 
SdcbpRationotropic glutamate receptor binding  IPIGrik1 (Rattus norvegicus)MMO:0000683RGD 
Grik1Ratprotein binding  IPISdcbp2 (Rattus norvegicus)MMO:0000683RGD 
Grik1Ratprotein binding  IDA Grip1 species unclear and MMO:0000683RGD 
Grik2Ratprotein binding  IPISdcbp2 (Rattus norvegicus)MMO:0000683RGD 
Grik2Ratprotein binding  IPIGrip1 (Rattus norvegicus)MMO:0000683RGD 
Grik2Ratprotein binding  IPIDlg4 (Rattus norvegicus)MMO:0000683RGD 
Grik1Ratscaffold protein binding  IDA Dlg4 species unclear and MMO:0000683RGD 
Grik2Ratscaffold protein binding  IDA Dlg4 species unclear and MMO:0000683RGD 
Grik1RatSNARE binding  IPIPick1 (Rattus norvegicus)MMO:0000683RGD 
Grik2RatSNARE binding  IPIPick1 (Rattus norvegicus)MMO:0000683RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik1  (glutamate ionotropic receptor kainate type subunit 1)
Grik2  (glutamate ionotropic receptor kainate type subunit 2)
Grip1  (glutamate receptor interacting protein 1)
Pick1  (protein interacting with PRKCA 1)
Sdcbp  (syndecan binding protein)

Objects referenced in this article
Gene Dlg4 discs large MAGUK scaffold protein 4 Rattus norvegicus

Additional Information