Gene: CD163 (CD163 molecule) Homo sapiens
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Symbol:
CD163
Name:
CD163 molecule
RGD ID:
1321258
Description:
Predicted to have scavenger receptor activity. Predicted to be involved in receptor-mediated endocytosis. Localizes to external side of plasma membrane.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Cd163 (CD163 antigen) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Cd163 (CD163 molecule) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther
Pan paniscus (bonobo/pygmy chimpanzee):
CD163 (CD163 molecule) NCBI
Ortholog
Canis lupus familiaris (dog):
CD163 (CD163 molecule) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Sus scrofa (pig):
CD163 (CD163 molecule) HGNC
Ensembl, Inparanoid, NCBI, OrthoDB, Panther
Chlorocebus sabaeus (African green monkey):
CD163 (CD163 molecule) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Cd163 (CD163 molecule) NCBI
Ortholog
Other homologs 2
Canis lupus familiaris (dog):
LOC486923 (deleted in malignant brain tumors 1 protein-like) HGNC
OrthoMCL
Canis lupus familiaris (dog):
DMBT1 (deleted in malignant brain tumors 1) HGNC
OrthoMCL
Canis lupus familiaris (dog):
LOC611565 (antigen WC1.1-like) HGNC
OrthoMCL
Mus musculus (house mouse):
Cd5 (CD5 antigen) HGNC
Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cd163 (CD163 molecule)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Mus musculus (house mouse):
Cd163 (CD163 antigen)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|Roundup|TreeFam)
Danio rerio (zebrafish):
si:dkey-21h14.8
Alliance
DIOPT (OrthoInspector|TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38.p13 Ensembl 12 7,470,813 - 7,503,893 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 12 7,470,811 - 7,503,808 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 12 7,623,412 - 7,656,414 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 12 7,514,676 - 7,547,681 (-) NCBI NCBI36 hg18 NCBI36 Build 34 12 7,515,020 - 7,547,639 NCBI Celera 12 9,198,918 - 9,231,725 (-) NCBI Cytogenetic Map 12 p13.31 NCBI HuRef 12 7,436,319 - 7,469,334 (-) NCBI HuRef CHM1_1 12 7,622,379 - 7,655,379 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
COVID-19 HEP 28912744 mRNA:increased expression:peripheral blood mononuclear cell (human) RGD
Imported Annotations - ClinVar
Hyperphosphatemic Familial Tumoral Calcinosis 1 IAGP RGD:14395239 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 1 ClinVar PMID:25378588 , PMID:29389098 Temtamy syndrome IAGP RGD:14711101 8554872 ClinVar Annotator: match by term: Temtamy syndrome ClinVar PMID:28492532 Temtamy syndrome IAGP RGD:26888978 8554872 ClinVar Annotator: match by term: Temtamy syndrome ClinVar PMID:28492532
Imported Annotations - CTD
carotid artery disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17095719 Experimental Liver Cirrhosis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 hepatocellular carcinoma EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 hyperglycemia EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29035695 hyperinsulinism EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29035695 IgA glomerulonephritis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25133636 Insulin Resistance EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29035695 obesity EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29035695 Spontaneous Abortions EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642
1-naphthyl isothiocyanate increases expression ISO RGD:1310382 6480464 1-Naphthylisothiocyanate results in increased expression of CD163 mRNA CTD PMID:25380136 17beta-estradiol increases expression ISO RGD:1321259 6480464 Estradiol results in increased expression of CD163 mRNA CTD PMID:19484750 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1321259 6480464 Tetrachlorodibenzodioxin affects the expression of CD163L1 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1310382 6480464 Tetrachlorodibenzodioxin results in increased expression of CD163 mRNA CTD PMID:32109520 2-butoxyethanol increases expression ISO RGD:1321259 6480464 n-butoxyethanol results in increased expression of CD163 mRNA CTD PMID:19812364 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression ISO RGD:1310382 6480464 4, 4'-diaminodiphenylmethane results in increased expression of CD163 mRNA CTD PMID:25380136 4-hydroxyphenyl retinamide decreases expression ISO RGD:1321259 6480464 Fenretinide results in decreased expression of CD163 mRNA CTD PMID:28973697 acetamide increases expression ISO RGD:1310382 6480464 acetamide results in increased expression of CD163 mRNA CTD PMID:31881176 aflatoxin B1 decreases expression ISO RGD:1310382 6480464 Aflatoxin B1 results in decreased expression of CD163 mRNA CTD PMID:23630614 , PMID:25378103 antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of CD163 mRNA CTD PMID:24449571 arsenite(3-) increases methylation EXP 6480464 arsenite results in increased methylation of CD163 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CD163 mRNA CTD PMID:20064835 benzo[a]pyrene decreases methylation EXP 6480464 Benzo(a)pyrene results in decreased methylation of CD163 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1321259 6480464 Benzo(a)pyrene results in increased expression of CD163 mRNA CTD PMID:22228805 , PMID:27195522 benzo[a]pyrene decreases expression ISO RGD:1321259 6480464 Benzo(a)pyrene results in decreased expression of CD163 mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:1321259 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CD163 mRNA] CTD PMID:22228805 bisphenol A decreases expression ISO RGD:1310382 6480464 bisphenol A results in decreased expression of CD163 mRNA, bisphenol A results in decreased expression of CD163L1 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A multiple interactions ISO RGD:1321259 6480464 bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA] CTD PMID:29718165 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA CTD PMID:28628672 , PMID:30398665 bisphenol A decreases methylation ISO RGD:1321259 6480464 bisphenol A results in decreased methylation of CD163 promoter, bisphenol A results in decreased methylation of CD163L1 promoter CTD PMID:27312807 bisphenol A multiple interactions ISO RGD:1310382 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of CD163L1 mRNA CTD PMID:26496021 bisphenol F multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA CTD PMID:28628672 buta-1,3-diene increases expression ISO RGD:1321259 6480464 1, 3-butadiene results in increased expression of CD163 mRNA CTD PMID:29038090 cadmium dichloride decreases expression ISO RGD:1310382 6480464 Cadmium Chloride results in decreased expression of CD163 mRNA CTD PMID:25993096 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of CD163 mRNA CTD PMID:26485663 chloroprene increases expression ISO RGD:1310382 6480464 Chloroprene results in increased expression of CD163 mRNA CTD PMID:23125180 chloroprene increases expression ISO RGD:1321259 6480464 Chloroprene results in increased expression of CD163 mRNA CTD PMID:23125180 choline affects expression EXP 6480464 Choline affects the expression of CD163 mRNA CTD PMID:17616785 copper atom multiple interactions ISO RGD:1310382 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA CTD PMID:25813056 copper(0) multiple interactions ISO RGD:1310382 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA CTD PMID:25813056 crocidolite asbestos increases expression ISO RGD:1321259 6480464 Asbestos, Crocidolite results in increased expression of CD163 mRNA CTD PMID:29507420 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CD163 mRNA CTD PMID:27989131 D-penicillamine decreases expression ISO RGD:1310382 6480464 Penicillamine results in decreased expression of CD163 mRNA CTD PMID:19575532 D-penicillamine increases expression ISO RGD:1310382 6480464 Penicillamine results in increased expression of CD163 mRNA CTD PMID:19575532 Deguelin multiple interactions ISO RGD:1310382 6480464 [deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA CTD PMID:22745725 dexamethasone increases expression ISO RGD:1310382 6480464 Dexamethasone results in increased expression of CD163 protein CTD PMID:17410599 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA CTD PMID:28628672 diclofenac increases expression ISO RGD:1321259 6480464 Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 dioxygen multiple interactions ISO RGD:1310382 6480464 [deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA CTD PMID:22745725 disulfiram multiple interactions EXP 6480464 [Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA CTD PMID:32712770 disulfiram decreases expression EXP 6480464 Disulfiram results in decreased expression of CD163 mRNA CTD PMID:32712770 diuron decreases expression ISO RGD:1310382 6480464 Diuron results in decreased expression of CD163 mRNA CTD PMID:25152437 ethanol multiple interactions ISO RGD:1321259 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CD163 mRNA, [Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA CTD PMID:26858005 , PMID:30517762 ethanol increases expression ISO RGD:1321259 6480464 Ethanol results in increased expression of CD163 mRNA CTD PMID:23832548 , PMID:26858005 flutamide decreases expression ISO RGD:1310382 6480464 Flutamide results in decreased expression of CD163 mRNA CTD PMID:24136188 fructose multiple interactions ISO RGD:1310382 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA CTD PMID:25813056 fructose multiple interactions ISO RGD:1321259 6480464 [Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA CTD PMID:26858005 furan decreases expression ISO RGD:1310382 6480464 furan results in decreased expression of CD163L1 mRNA CTD PMID:25539665 gadolinium trichloride multiple interactions ISO RGD:1310382 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:25813056 , PMID:26177832 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA CTD PMID:28628672 irinotecan increases expression ISO RGD:1310382 6480464 Irinotecan results in increased expression of CD163 mRNA CTD PMID:20097248 isoprenaline increases expression ISO RGD:1321259 6480464 Isoproterenol results in increased expression of CD163 mRNA CTD PMID:20003209 lead diacetate increases expression ISO RGD:1310382 6480464 lead acetate results in increased expression of CD163 mRNA CTD PMID:22641619 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of CD163 mRNA, Lipopolysaccharides results in increased expression of CD163 protein CTD PMID:26918785 lipopolysaccharide multiple interactions ISO RGD:1321259 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA more ... CTD PMID:29718165 lipopolysaccharide multiple interactions EXP 6480464 methyl 2-cyano-3 more ... CTD PMID:26918785 mechlorethamine increases expression ISO RGD:1310382 6480464 Mechlorethamine results in increased expression of CD163 protein CTD PMID:26273949 medroxyprogesterone acetate increases expression EXP 6480464 Medroxyprogesterone Acetate results in increased expression of CD163 mRNA CTD PMID:20843944 methimazole multiple interactions ISO RGD:1310382 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:26177832 mono(2-ethylhexyl) phthalate increases expression ISO RGD:1321259 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of CD163 protein CTD PMID:22143055 mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA CTD PMID:30398665 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:1321259 6480464 mono-(2-ethylhexyl)phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA] CTD PMID:29718165 monobenzyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA CTD PMID:30398665 Monobutylphthalate multiple interactions EXP 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA CTD PMID:30398665 N-nitrosodiethylamine multiple interactions ISO RGD:1321259 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CD163 mRNA CTD PMID:24535843 N-nitrosodiethylamine decreases expression ISO RGD:1321259 6480464 Diethylnitrosamine results in decreased expression of CD163 mRNA CTD PMID:24535843 nickel atom increases expression EXP 6480464 Nickel results in increased expression of CD163 mRNA CTD PMID:24768652 , PMID:25583101 ozone increases expression ISO RGD:1321259 6480464 Ozone results in increased expression of CD163 mRNA CTD PMID:17095637 paclitaxel increases expression ISO RGD:1310382 6480464 Paclitaxel results in increased expression of CD163 mRNA CTD PMID:18754875 paracetamol affects expression ISO RGD:1321259 6480464 Acetaminophen affects the expression of CD163 mRNA, Acetaminophen affects the expression of CD163L1 mRNA CTD PMID:17562736 phenobarbital decreases expression ISO RGD:1321259 6480464 Phenobarbital results in decreased expression of CD163 mRNA CTD PMID:19482888 phenobarbital affects expression ISO RGD:1321259 6480464 Phenobarbital affects the expression of CD163 mRNA, Phenobarbital affects the expression of CD163L1 mRNA CTD PMID:23091169 phenobarbital multiple interactions ISO RGD:1321259 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CD163 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CD163 mRNA] CTD PMID:19482888 , PMID:24535843 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD163 mRNA CTD PMID:19710929 resveratrol multiple interactions ISO RGD:1310382 6480464 [resveratrol co-treated with Streptozocin] results in increased expression of CD163 mRNA CTD PMID:25905778 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:1310382 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:26177832 silicon dioxide decreases expression ISO RGD:1321259 6480464 Silicon Dioxide results in decreased expression of CD163 mRNA CTD PMID:23221170 sodium arsenate increases expression ISO RGD:1321259 6480464 sodium arsenate results in increased expression of CD163 mRNA CTD PMID:21795629 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of CD163 mRNA CTD PMID:29301061 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of CD163 mRNA CTD PMID:17685462 sodium fluoride increases expression ISO RGD:1321259 6480464 Sodium Fluoride results in increased expression of CD163 protein CTD PMID:28918527 streptozocin multiple interactions ISO RGD:1310382 6480464 [resveratrol co-treated with Streptozocin] results in increased expression of CD163 mRNA CTD PMID:25905778 sulforaphane increases expression ISO RGD:1321259 6480464 sulforafan results in increased expression of CD163 mRNA CTD PMID:30529165 tamoxifen affects expression ISO RGD:1321259 6480464 Tamoxifen affects the expression of CD163 mRNA CTD PMID:20937368 testosterone multiple interactions ISO RGD:1310382 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of CD163L1 mRNA CTD PMID:26496021 tetrachloromethane increases expression ISO RGD:1321259 6480464 Carbon Tetrachloride results in increased expression of CD163 mRNA CTD PMID:27339419 , PMID:31919559 tetrachloromethane multiple interactions ISO RGD:1321259 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CD163 mRNA CTD PMID:30517762 titanium dioxide increases expression ISO RGD:1321259 6480464 titanium dioxide results in increased expression of CD163L1 mRNA CTD PMID:23409001 , PMID:23557971 topotecan increases expression ISO RGD:1310382 6480464 Topotecan results in increased expression of CD163 mRNA CTD PMID:25729387 triphenyl phosphate decreases expression ISO RGD:1310382 6480464 triphenyl phosphate results in decreased expression of CD163 mRNA CTD PMID:30589522 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CD163 mRNA CTD PMID:29154799 valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of CD163 mRNA CTD PMID:22768174 vinclozolin increases expression ISO RGD:1310382 6480464 vinclozolin results in increased expression of CD163 mRNA CTD PMID:23034163 zinc sulfate multiple interactions EXP 6480464 [Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA CTD PMID:32712770 ziram decreases expression EXP 6480464 Ziram results in decreased expression of CD163 mRNA, Ziram results in decreased expression of CD163 protein CTD PMID:32712770
Gene-Chemical Interaction Annotations
