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Gene: SHANK1 (SH3 and multiple ankyrin repeat domains 1) Homo sapiens
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Symbol: SHANK1
Name: SH3 and multiple ankyrin repeat domains 1
Description: Predicted to have several functions, including GKAP/Homer scaffold activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including determination of affect; social behavior; and vocalization behavior. Localizes to plasma membrane. Predicted to colocalize with NMDA selective glutamate receptor complex and postsynaptic membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: SH3 and multiple ankyrin repeat domains protein 1; somatostatin receptor-interacting protein; SPANK-1; SSTR-interacting protein; SSTRIP; synamon
Orthologs:
Mus musculus (house mouse) : Shank1 (SH3 and multiple ankyrin repeat domains 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shank1 (SH3 and multiple ankyrin repeat domains 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Canis lupus familiaris (dog) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Sus scrofa (pig) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Chlorocebus sabaeus (African green monkey) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Heterocephalus glaber (naked mole-rat) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1950,661,827 - 50,719,450 (-)EnsemblGRCh38hg38GRCh38
GRCh381950,659,255 - 50,719,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371951,163,052 - 51,220,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,856,896 - 55,912,007 (-)NCBINCBI36hg18NCBI36
Build 341955,856,895 - 55,912,007NCBI
Celera1948,216,374 - 48,271,323 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,499,910 - 47,555,290 (-)NCBIHuRef
CHM1_11951,164,298 - 51,221,938 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SHANK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734100
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.