GRK2 (G protein-coupled receptor kinase 2) - Rat Genome Database

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Gene: GRK2 (G protein-coupled receptor kinase 2) Homo sapiens
Analyze
Symbol: GRK2
Name: G protein-coupled receptor kinase 2
RGD ID: 731036
HGNC Page HGNC:289
Description: Enables Edg-2 lysophosphatidic acid receptor binding activity and G protein-coupled receptor kinase activity. Involved in several processes, including negative regulation of the force of heart contraction by chemical signal; regulation of muscle system process; and tachykinin receptor signaling pathway. Located in cytoplasm. Biomarker of several diseases, including bacterial pneumonia; liver cirrhosis; pituitary adenoma; rheumatoid arthritis; and toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADRBK1; adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; BARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; BETA-ARK1; FLJ16718; G-protein coupled receptor kinase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,266,473 - 67,286,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1167,266,473 - 67,286,556 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,033,944 - 67,054,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,790,481 - 66,810,605 (+)NCBINCBI36Build 36hg18NCBI36
Build 341166,790,668 - 66,810,945NCBI
Celera1164,377,313 - 64,386,599 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,362,803 - 63,382,690 (+)NCBIHuRef
CHM1_11166,912,110 - 66,937,037 (+)NCBICHM1_1
T2T-CHM13v2.01167,260,429 - 67,280,532 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cardiac muscle contraction  (IMP)
cellular response to catecholamine stimulus  (ISO)
cellular response to chemokine  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to rapamycin  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled acetylcholine receptor signaling pathway  (ISS)
G protein-coupled receptor signaling pathway  (IBA,IEA,ISO,TAS)
heart development  (IEA,ISO)
maintenance of protein location in nucleus  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of relaxation of smooth muscle  (IEA,IMP)
negative regulation of striated muscle contraction  (IMP)
negative regulation of the force of heart contraction by chemical signal  (IMP)
oligodendrocyte differentiation  (ISO)
peptidyl-serine phosphorylation  (IEA,ISO,ISS)
peptidyl-threonine phosphorylation  (IEA,ISO)
phosphorylation  (IEA)
positive regulation of catecholamine secretion  (ISS)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of muscle cell apoptotic process  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (ISO)
protein phosphorylation  (IBA,IEA,ISO)
receptor internalization  (IDA)
regulation of signal transduction  (IBA)
regulation of the force of heart contraction  (IBA,IEA,ISO)
response to caloric restriction  (ISO)
response to hydrogen peroxide  (ISO)
response to leptin  (ISO)
response to morphine  (ISO)
response to muscle activity  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
signal transduction  (IEA)
signal transduction  (IEA)
tachykinin receptor signaling pathway  (IDA)
vasodilation  (ISO)
viral entry into host cell  (IMP)
viral genome replication  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. Anderson KM, etal., Hypertension. 1999 Jan;33(1 Pt 2):402-7.
3. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Arraes SM, etal., Blood. 2006 Nov 1;108(9):2906-13. Epub 2006 Jul 18.
4. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55.
5. Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization. Basu D, etal., PLoS One. 2013 Aug 6;8(8):e70736. doi: 10.1371/journal.pone.0070736. Print 2013.
6. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. ß1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Cannavo A, etal., Circulation. 2013 Oct 8;128(15):1612-22. doi: 10.1161/CIRCULATIONAHA.113.002659. Epub 2013 Aug 22.
8. ß Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves ß2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia. Cannavo A, etal., J Pharmacol Exp Ther. 2016 Feb;356(2):503-13. doi: 10.1124/jpet.115.228411. Epub 2015 Nov 24.
9. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Chen M, etal., Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6.
10. Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats. Chen W, etal., Hepatobiliary Pancreat Dis Int. 2013 Jun;12(3):295-304.
11. G protein coupled receptor kinase-2 upregulation causes ¿-opioid receptor desensitization in diabetic heart. Chen X, etal., Biochem Biophys Res Commun. 2017 Jan 22;482(4):658-664. doi: 10.1016/j.bbrc.2016.11.090. Epub 2016 Nov 16.
12. Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia. Dong J, etal., Auton Neurosci. 2015 Jan;187:76-83. doi: 10.1016/j.autneu.2014.10.024. Epub 2014 Nov 1.
13. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
14. Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats. Du QH, etal., World J Gastroenterol. 2014 Nov 28;20(44):16674-82. doi: 10.3748/wjg.v20.i44.16674.
15. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
16. Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Ferrari LF, etal., Neuroscience. 2012 Oct 11;222:392-403. doi: 10.1016/j.neuroscience.2012.07.004. Epub 2012 Jul 13.
17. ß-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly. Gatto F, etal., Endocrinology. 2013 Dec;154(12):4715-25. doi: 10.1210/en.2013-1672. Epub 2013 Oct 29.
18. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
19. G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Gros R, etal., Hypertension. 2000 Jan;35(1 Pt 1):38-42.
20. Biventricular differences in ß-adrenergic receptor signaling following burn injury. Guillory AN, etal., PLoS One. 2017 Dec 12;12(12):e0189527. doi: 10.1371/journal.pone.0189527. eCollection 2017.
21. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
22. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Harding VB, etal., Proc Natl Acad Sci U S A 2001 May 8;98(10):5809-14. Epub 2001 May 1.
23. Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28.
24. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg M, etal., Hepatology. 2007 Feb;45(2):495-506.
25. Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Huang ZM, etal., Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.
26. G protein-coupled receptor kinase (GRK)2 is a key negative regulator of itch: L-glutamine attenuates itch via a rapid induction of GRK2 in an ERK-dependent way. Im YN, etal., J Invest Dermatol. 2018 Mar 9. pii: S0022-202X(18)30220-3. doi: 10.1016/j.jid.2018.02.036.
27. Small molecule disruption of G protein ß¿ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. Karuppagounder V, etal., PLoS One. 2018 Jul 19;13(7):e0200697. doi: 10.1371/journal.pone.0200697. eCollection 2018.
28. Parathyroid hormone signaling in bone and kidney. Lee M and Partridge NC, Curr Opin Nephrol Hypertens. 2009 Jul;18(4):298-302. doi: 10.1097/MNH.0b013e32832c2264.
29. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Liu H, etal., Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29.
30. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Liu S, etal., Nat Med. 2005 Sep;11(9):952-8. Epub 2005 Sep 4.
31. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
32. A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2. Lu C, etal., Cell Mol Neurobiol. 2017 Jan;37(1):101-109. doi: 10.1007/s10571-016-0349-0. Epub 2016 Mar 2.
33. Tempol reduces oxidative stress and restores renal dopamine D1-like receptor- G protein coupling and function in hyperglycemic rats. Marwaha A and Lokhandwala MF, Am J Physiol Renal Physiol. 2006 Jul;291(1):F58-66. Epub 2006 Feb 14.
34. beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
35. Hypertensive left ventricular hypertrophy: relation to beta-adrenergic receptor kinase-1 (betaARK1) in peripheral lymphocytes. Park SJ, etal., J Hypertens. 2004 May;22(5):1025-32.
36. Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects. Perianes-Cachero A, etal., Neurochem Int. 2012 Dec;61(8):1385-96. doi: 10.1016/j.neuint.2012.09.019. Epub 2012 Oct 13.
37. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
38. GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Piao L, etal., Circulation. 2012 Dec 11;126(24):2859-69. doi: 10.1161/CIRCULATIONAHA.112.109868. Epub 2012 Nov 2.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Polhemus DJ, etal., Circ Res. 2016 Jul 22;119(3):470-80. doi: 10.1161/CIRCRESAHA.115.308278. Epub 2016 Jun 13.
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Rockman HA, etal., Proc Natl Acad Sci U S A 1998 Jun 9;95(12):7000-5.
44. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. Schlegel P, etal., PLoS One. 2017 Jul 31;12(7):e0182110. doi: 10.1371/journal.pone.0182110. eCollection 2017.
45. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
46. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy. Sorriento D, etal., J Cardiovasc Transl Res. 2015 Nov;8(8):493-502. doi: 10.1007/s12265-015-9646-0. Epub 2015 Jul 30.
47. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
48. Gene expression analysis of TREM1 and GRK2 in polymorphonuclear leukocytes as the surrogate biomarkers of acute bacterial infections. Ubagai T, etal., Int J Med Sci. 2014 Jan 10;11(2):215-21. doi: 10.7150/ijms.7231. eCollection 2014.
49. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Usui I, etal., Mol Endocrinol. 2005 Nov;19(11):2760-8. Epub 2005 Jun 30.
50. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
51. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Wang Q, etal., Sci Rep. 2017 Mar 28;7:45364. doi: 10.1038/srep45364.
52. G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes. Wans ZH, etal., Asian J Androl. 2018 Sep 14. pii: 241306.
53. The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats. Won KA, etal., J Pain. 2014 Mar;15(3):250-61. doi: 10.1016/j.jpain.2013.10.013. Epub 2013 Nov 8.
54. Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury. Woodall MC, etal., Circ Res. 2016 Oct 28;119(10):1116-1127. doi: 10.1161/CIRCRESAHA.116.309538. Epub 2016 Sep 6.
55. Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats. Xing W, etal., Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1111-9. doi: 10.1152/ajpheart.00290.2013. Epub 2013 Aug 2.
56. A Non-Canonical Function of Gbeta as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Zha Z, etal., Mol Cell. 2015 Jun 4;58(5):794-803. doi: 10.1016/j.molcel.2015.04.017. Epub 2015 May 14.
57. (-)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of ß1 adrenoceptor via GRK2 in experimental heart failure. Zhang Q, etal., Inflammopharmacology. 2017 Dec 16. pii: 10.1007/s10787-017-0429-x. doi: 10.1007/s10787-017-0429-x.
58. 2K1C-activated Angiotensin II (Ang II) exacerbates vascular damage in a rat model of arthritis through the ATR/ERK1/2 signaling pathway. Zhang Y, etal., Inflamm Res. 2017 Oct;66(10):881-890. doi: 10.1007/s00011-017-1069-8. Epub 2017 Jun 26.
59. Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats. Zhang ZR, etal., Phytother Res. 2017 Aug;31(8):1249-1256. doi: 10.1002/ptr.5847. Epub 2017 Jun 19.
60. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:1339451   PMID:2037065   PMID:7836371   PMID:7876239   PMID:8195124   PMID:8662816   PMID:8672451   PMID:8885248   PMID:9211925   PMID:9446593   PMID:9501202   PMID:9826657  
PMID:10085129   PMID:10085131   PMID:10091590   PMID:10379886   PMID:10467231   PMID:10567430   PMID:10574913   PMID:10617630   PMID:10722682   PMID:10727525   PMID:10727532   PMID:10744734  
PMID:10754297   PMID:10852916   PMID:10858453   PMID:10861009   PMID:10884381   PMID:10896954   PMID:11040053   PMID:11042191   PMID:11278469   PMID:11309381   PMID:11517230   PMID:11762794  
PMID:12107237   PMID:12123746   PMID:12130691   PMID:12130708   PMID:12163475   PMID:12351722   PMID:12379128   PMID:12381737   PMID:12435819   PMID:12456365   PMID:12477932   PMID:12486133  
PMID:12507501   PMID:12552191   PMID:12624098   PMID:12639913   PMID:12679936   PMID:12750365   PMID:12885252   PMID:14557268   PMID:14602721   PMID:14654844   PMID:14729942   PMID:14997482  
PMID:15051637   PMID:15102938   PMID:15271984   PMID:15471870   PMID:15489334   PMID:15542600   PMID:15569306   PMID:15618519   PMID:15620700   PMID:15653687   PMID:15778405   PMID:15843435  
PMID:15870073   PMID:15919661   PMID:16077899   PMID:16081410   PMID:16091361   PMID:16094730   PMID:16121194   PMID:16356165   PMID:16605244   PMID:16725308   PMID:16920721   PMID:16984558  
PMID:17000469   PMID:17006543   PMID:17008309   PMID:17055984   PMID:17102134   PMID:17146290   PMID:17276003   PMID:17482545   PMID:17544362   PMID:17548351   PMID:17893145   PMID:17986524  
PMID:17998459   PMID:18369319   PMID:18425130   PMID:18451066   PMID:18463167   PMID:18511496   PMID:18854154   PMID:18976975   PMID:19008357   PMID:19257866   PMID:19292735   PMID:19306925  
PMID:19338266   PMID:19487588   PMID:19502428   PMID:19620130   PMID:19815545   PMID:19846537   PMID:19906838   PMID:19913121   PMID:19946888   PMID:19953087   PMID:20074556   PMID:20080565  
PMID:20335112   PMID:20443852   PMID:20443948   PMID:20460384   PMID:20468064   PMID:20493668   PMID:20501412   PMID:20628086   PMID:20684281   PMID:20696855   PMID:20730384   PMID:20807772  
PMID:20814022   PMID:20861385   PMID:21081496   PMID:21127457   PMID:21283592   PMID:21464134   PMID:21473908   PMID:21705320   PMID:21784156   PMID:21873635   PMID:21900206   PMID:21940795  
PMID:21952200   PMID:21983013   PMID:21988832   PMID:22089113   PMID:22193721   PMID:22196842   PMID:22375000   PMID:22447027   PMID:22589388   PMID:22658674   PMID:22731384   PMID:22735336  
PMID:23029581   PMID:23076141   PMID:23082996   PMID:23139825   PMID:23208013   PMID:23221335   PMID:23312955   PMID:23362259   PMID:23455922   PMID:23460259   PMID:23494575   PMID:23689525  
PMID:23705503   PMID:23734232   PMID:23826079   PMID:23904266   PMID:23940030   PMID:24064210   PMID:24135140   PMID:24613411   PMID:24702056   PMID:24812353   PMID:24904059   PMID:25049229  
PMID:25279970   PMID:25316767   PMID:25857770   PMID:26092485   PMID:26228571   PMID:26234354   PMID:26344197   PMID:26402907   PMID:26447102   PMID:26496610   PMID:26670611   PMID:26706289  
PMID:26885983   PMID:26936374   PMID:27058419   PMID:27188791   PMID:27346572   PMID:27362616   PMID:27462452   PMID:27555048   PMID:27714516   PMID:27720394   PMID:28130200   PMID:28202495  
PMID:28319085   PMID:28514442   PMID:28572156   PMID:28579429   PMID:28594409   PMID:28718761   PMID:28843497   PMID:28882814   PMID:29054428   PMID:29487132   PMID:29864421   PMID:30018141  
PMID:30261289   PMID:30284927   PMID:30703414   PMID:31253779   PMID:31554835   PMID:31604529   PMID:31680450   PMID:31811856   PMID:31850518   PMID:31961340   PMID:31980649   PMID:31986892  
PMID:32096468   PMID:32513696   PMID:32707033   PMID:32814053   PMID:32962859   PMID:33060647   PMID:33148713   PMID:33158816   PMID:33200460   PMID:33313679   PMID:33430208   PMID:33465377  
PMID:33466800   PMID:33467677   PMID:33802765   PMID:33806062   PMID:33844281   PMID:33961781   PMID:34079125   PMID:35271311   PMID:35341806   PMID:35831314   PMID:35878706   PMID:36063601  
PMID:36461590   PMID:36622065  


Genomics

Comparative Map Data
GRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,266,473 - 67,286,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1167,266,473 - 67,286,556 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,033,944 - 67,054,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,790,481 - 66,810,605 (+)NCBINCBI36Build 36hg18NCBI36
Build 341166,790,668 - 66,810,945NCBI
Celera1164,377,313 - 64,386,599 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,362,803 - 63,382,690 (+)NCBIHuRef
CHM1_11166,912,110 - 66,937,037 (+)NCBICHM1_1
T2T-CHM13v2.01167,260,429 - 67,280,532 (+)NCBIT2T-CHM13v2.0
Grk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,336,027 - 4,356,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,336,029 - 4,356,250 (-)EnsemblGRCm39 Ensembl
GRCm38194,285,999 - 4,306,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,286,001 - 4,306,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,286,001 - 4,305,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,286,001 - 4,305,955 (-)NCBIMGSCv36mm8
Celera194,157,228 - 4,177,197 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.98NCBI
Grk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,581,480 - 201,601,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,581,480 - 201,601,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,932,926 - 209,953,677 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01217,026,270 - 217,047,026 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01209,717,288 - 209,738,044 (-)NCBIRnor_WKY
Rnor_6.01219,536,220 - 219,544,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,536,220 - 219,544,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,406,333 - 226,414,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,873,002 - 206,892,868 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,026,454 - 207,034,564 (-)NCBI
Celera1199,125,797 - 199,145,728 (-)NCBICelera
RH 3.4 Map11560.2RGD
Cytogenetic Map1q43NCBI
Grk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,170,616 - 18,192,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,173,438 - 18,192,357 (-)NCBIChiLan1.0ChiLan1.0
GRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,939,169 - 65,959,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,939,164 - 65,959,066 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01162,624,647 - 62,644,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,148,566 - 50,167,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,148,598 - 50,167,428 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,758,688 - 48,777,641 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,097,619 - 51,116,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,097,625 - 51,116,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,283,520 - 50,302,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,858,001 - 49,876,975 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,652,610 - 50,671,586 (-)NCBIUU_Cfam_GSD_1.0
Grk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,994,712 - 6,013,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,437,032 - 2,456,147 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365992,437,061 - 2,456,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,209,439 - 5,227,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,209,435 - 5,227,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,992,505 - 4,000,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,975,202 - 6,995,369 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,975,002 - 6,995,259 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,263,440 - 104,283,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,210,965 - 19,231,082 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,212,218 - 19,231,218 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRK2
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2(chr11:66885910-67698250)x1 copy number loss See cases [RCV000052682] Chr11:66885910..67698250 [GRCh38]
Chr11:66653381..67465721 [GRCh37]
Chr11:66409957..67222297 [NCBI36]
Chr11:11q13.2		 pathogenic
GRCh38/hg38 11q13.2(chr11:66193502-67890770)x3 copy number gain See cases [RCV000053623] Chr11:66193502..67890770 [GRCh38]
Chr11:65960973..67658241 [GRCh37]
Chr11:65717549..67414817 [NCBI36]
Chr11:11q13.2		 pathogenic
GRCh38/hg38 11q13.2-13.3(chr11:67217264-69448598)x1 copy number loss See cases [RCV000135609] Chr11:67217264..69448598 [GRCh38]
Chr11:66984735..69263366 [GRCh37]
Chr11:66741311..68972547 [NCBI36]
Chr11:11q13.2-13.3		 likely pathogenic
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2		 pathogenic
GRCh37/hg19 11q13.2(chr11:66024774-67430781)x3 copy number gain See cases [RCV000240374] Chr11:66024774..67430781 [GRCh37]
Chr11:11q13.2		 uncertain significance
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001619.5(GRK2):c.1348_1349del (p.Ser450fs) microsatellite Jeune thoracic dystrophy [RCV001543385] Chr11:67283722..67283723 [GRCh38]
Chr11:67051193..67051194 [GRCh37]
Chr11:11q13.2		 likely pathogenic
NM_001619.5(GRK2):c.1492-5T>A single nucleotide variant not provided [RCV000943275] Chr11:67284206 [GRCh38]
Chr11:67051677 [GRCh37]
Chr11:11q13.2		 likely benign
NM_001619.5(GRK2):c.1153C>T (p.Leu385=) single nucleotide variant not provided [RCV000921112] Chr11:67282535 [GRCh38]
Chr11:67050006 [GRCh37]
Chr11:11q13.2		 likely benign
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2		 pathogenic
NM_001619.5(GRK2):c.1659C>T (p.Tyr553=) single nucleotide variant not provided [RCV000893312] Chr11:67284851 [GRCh38]
Chr11:67052322 [GRCh37]
Chr11:11q13.2		 benign
NC_000011.9:g.(?_64973914)_(70052579_?)dup duplication Aicardi-Goutieres syndrome 3 [RCV003113322]|FADD-related immunodeficiency [RCV003107753] Chr11:64973914..70052579 [GRCh37]
Chr11:11q13.1-13.3		 uncertain significance
NM_001619.5(GRK2):c.2069G>A (p.Ter690=) single nucleotide variant not provided [RCV000956968] Chr11:67285449 [GRCh38]
Chr11:67052920 [GRCh37]
Chr11:11q13.2		 benign
GRCh37/hg19 11q13.2(chr11:66820585-67979510)x3 copy number gain not provided [RCV001006414] Chr11:66820585..67979510 [GRCh37]
Chr11:11q13.2		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NM_001619.5(GRK2):c.469C>T (p.Leu157Phe) single nucleotide variant Jeune thoracic dystrophy [RCV001543384] Chr11:67279866 [GRCh38]
Chr11:67047337 [GRCh37]
Chr11:11q13.2		 pathogenic
NM_001619.5(GRK2):c.555+1G>A single nucleotide variant Jeune thoracic dystrophy [RCV001543386] Chr11:67280784 [GRCh38]
Chr11:67048255 [GRCh37]
Chr11:11q13.2		 likely pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_001619.5(GRK2):c.362C>T (p.Ser121Leu) single nucleotide variant Inborn genetic diseases [RCV003012638] Chr11:67279515 [GRCh38]
Chr11:67046986 [GRCh37]
Chr11:11q13.2		 uncertain significance
NM_001619.5(GRK2):c.1583C>T (p.Thr528Ile) single nucleotide variant Inborn genetic diseases [RCV002742454] Chr11:67284302 [GRCh38]
Chr11:67051773 [GRCh37]
Chr11:11q13.2		 uncertain significance
NM_001619.5(GRK2):c.1441G>A (p.Asp481Asn) single nucleotide variant Inborn genetic diseases [RCV002672851] Chr11:67283899 [GRCh38]
Chr11:67051370 [GRCh37]
Chr11:11q13.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5551
Count of miRNA genes:1107
Interacting mature miRNAs:1396
Transcripts:ENST00000308595, ENST00000416281, ENST00000524899, ENST00000526285, ENST00000526572, ENST00000527176, ENST00000529738, ENST00000529815, ENST00000530291, ENST00000531390, ENST00000532099, ENST00000532611, ENST00000533077, ENST00000534651
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
ADRBK1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371167,052,972 - 67,053,156UniSTSGRCh37
Build 361166,809,548 - 66,809,732RGDNCBI36
Celera1164,385,542 - 64,385,726RGD
HuRef1163,381,633 - 63,381,817UniSTS
GeneMap99-GB4 RH Map11254.38UniSTS
WI-15244  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371167,053,869 - 67,053,975UniSTSGRCh37
Build 361166,810,445 - 66,810,551RGDNCBI36
Celera1164,386,439 - 64,386,545RGD
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map11q13.2UniSTS
HuRef1163,382,530 - 63,382,636UniSTS
GeneMap99-GB4 RH Map11255.53UniSTS
Whitehead-RH Map11362.4UniSTS
MARC_15697-15698:1013523581:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371167,051,374 - 67,051,760UniSTSGRCh37
Build 361166,807,950 - 66,808,336RGDNCBI36
Celera1164,383,944 - 64,384,330RGD
HuRef1163,380,035 - 63,380,421UniSTS
adrbk1sts1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371167,051,741 - 67,052,371UniSTSGRCh37
Celera1164,384,311 - 64,384,941UniSTS
HuRef1163,380,402 - 63,381,032UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2432 2966 1701 601 1942 443 4354 2179 3674 386 1447 1607 171 1204 2788 4
Low 4 20 23 22 8 21 1 15 45 32 3 2 2 1 1
Below cutoff 3 2 1 1 1 2 14 1 10 3 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007062455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB005818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI888604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN989901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU326303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU177896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU177897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000308595   ⟹   ENSP00000312262
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,266,473 - 67,286,556 (+)Ensembl
RefSeq Acc Id: ENST00000416281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,276,537 - 67,286,555 (+)Ensembl
RefSeq Acc Id: ENST00000524899
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,284,271 - 67,285,591 (+)Ensembl
RefSeq Acc Id: ENST00000526285   ⟹   ENSP00000434126
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,266,481 - 67,286,536 (+)Ensembl
RefSeq Acc Id: ENST00000526572
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,281,684 - 67,283,959 (+)Ensembl
RefSeq Acc Id: ENST00000527176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,281,876 - 67,285,137 (+)Ensembl
RefSeq Acc Id: ENST00000529738
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,279,474 - 67,286,372 (+)Ensembl
RefSeq Acc Id: ENST00000529815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,282,125 - 67,283,231 (+)Ensembl
RefSeq Acc Id: ENST00000530291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,270,938 - 67,279,519 (+)Ensembl
RefSeq Acc Id: ENST00000531390
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,282,781 - 67,284,171 (+)Ensembl
RefSeq Acc Id: ENST00000532099
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,281,509 - 67,284,369 (+)Ensembl
RefSeq Acc Id: ENST00000532611
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,283,175 - 67,284,323 (+)Ensembl
RefSeq Acc Id: ENST00000533077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,280,194 - 67,284,622 (+)Ensembl
RefSeq Acc Id: ENST00000534651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1167,281,459 - 67,282,066 (+)Ensembl
RefSeq Acc Id: NM_001619   ⟹   NP_001610
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381167,266,473 - 67,286,556 (+)NCBI
GRCh371167,033,905 - 67,054,029 (+)ENTREZGENE
Build 361166,790,481 - 66,810,605 (+)NCBI Archive
HuRef1163,362,803 - 63,382,690 (+)ENTREZGENE
CHM1_11166,912,110 - 66,937,037 (+)NCBI
T2T-CHM13v2.01167,260,429 - 67,280,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544773   ⟹   XP_011543075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381167,267,196 - 67,286,556 (+)NCBI
Sequence:
RefSeq Acc Id: XR_007062455
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381167,266,473 - 67,284,347 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001610   ⟸   NM_001619
- UniProtKB: Q6GTT3 (UniProtKB/Swiss-Prot),   P25098 (UniProtKB/Swiss-Prot),   A0A0S2Z392 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011543075   ⟸   XM_011544773
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000312262   ⟸   ENST00000308595
RefSeq Acc Id: ENSP00000434126   ⟸   ENST00000526285
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25098-F1-model_v2 AlphaFold P25098 1-689 view protein structure

Promoters
RGD ID:6788431
Promoter ID:HG_KWN:13452
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001619,   UC009YRM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361166,790,299 - 66,790,799 (+)MPROMDB
RGD ID:6809932
Promoter ID:HG_ACW:12817
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ADRBK1.BAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361166,791,461 - 66,791,961 (+)MPROMDB
RGD ID:6809934
Promoter ID:HG_ACW:12818
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ADRBK1.IAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361166,794,061 - 66,794,561 (+)MPROMDB
RGD ID:6809933
Promoter ID:HG_ACW:12822
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:ADRBK1.DAPR07,   ADRBK1.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361166,800,906 - 66,801,406 (+)MPROMDB
RGD ID:6809935
Promoter ID:HG_ACW:12826
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ADRBK1.KAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361166,809,711 - 66,810,211 (+)MPROMDB
RGD ID:7221207
Promoter ID:EPDNEW_H16349
Type:initiation region
Name:ADRBK1_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381167,266,473 - 67,266,533EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:289 AgrOrtholog
COSMIC GRK2 COSMIC
Ensembl Genes ENSG00000173020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000312262 ENTREZGENE
  ENSP00000312262.5 UniProtKB/Swiss-Prot
  ENSP00000434126.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000308595 ENTREZGENE
  ENST00000308595.10 UniProtKB/Swiss-Prot
  ENST00000526285.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.1270 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000173020 GTEx
HGNC ID HGNC:289 ENTREZGENE
Human Proteome Map GRK2 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 156 ENTREZGENE
OMIM 109635 OMIM
PANTHER BETA-ADRENERGIC RECEPTOR KINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA40 PharmGKB
PRINTS GPCRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z392 ENTREZGENE, UniProtKB/TrEMBL
  ARBK1_HUMAN UniProtKB/Swiss-Prot
  E9PRV7_HUMAN UniProtKB/TrEMBL
  P25098 ENTREZGENE
  Q6GTT3 ENTREZGENE
UniProt Secondary B0ZBE1 UniProtKB/Swiss-Prot
  Q13837 UniProtKB/Swiss-Prot
  Q6GTT3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-19 GRK2  G protein-coupled receptor kinase 2  ADRBK1  adrenergic, beta, receptor kinase 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 ADRBK1  adrenergic, beta, receptor kinase 1  ADRBK1  adrenergic, beta, receptor kinase 1  Symbol and/or name change 5135510 APPROVED