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ONTOLOGY REPORT - ANNOTATIONS

Term:E-box binding
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Accession:GO:0070888 term browser browse the term
Definition:Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
Synonyms:exact_synonym: E-box promoter binding


show annotations for term's descendants           Sort by:
E-box binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor enables ISO
ISS		 (MGI:4820700|PMID:20106950)
GO_REF:0000024		 RGD
UniProt		 PMID:20106950 GO_REF:0000024 MGI:4820700 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 enables ISO (PMID:10903890), (PMID:11736660) RGD PMID:10903890 PMID:11736660 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 enables ISO (PMID:14561729) RGD PMID:14561729 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Atoh1 atonal bHLH transcription factor 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154 		JBrowse link
G Atoh7 atonal bHLH transcription factor 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:25,530,826...25,531,275
Ensembl chr20:25,530,826...25,531,275 		JBrowse link
G Atoh8 atonal bHLH transcription factor 8 enables ISO
IBA		 (PMID:24236640)
GO_REF:0000033		 RGD
GO_Central		 PMID:24236640 GO_REF:0000033 NCBI chr 4:104,259,992...104,292,168
Ensembl chr 4:104,259,992...104,292,168 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713 		JBrowse link
G Bhlhe22 basic helix-loop-helix family, member e22 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:100,486,400...100,489,510
Ensembl chr 2:100,486,400...100,489,510 		JBrowse link
G Bhlhe23 basic helix-loop-helix family, member e23 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:167,889,009...167,891,223
Ensembl chr 3:167,889,009...167,891,223 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 enables IEA
ISO
ISS		 GO_REF:0000107
(PMID:12397359), (PMID:12624110), (PMID:14672706), (PMID:15193144), (PMID:15560782), (PMID:18411297), (PMID:28797635)
GO_REF:0000024
(MGI:2388855|PMID:12397359), (MGI:5297789|PMID:15147242), (MGI:5306297|PMID:17487425), (MGI:6282958|PMID:30012868)		 Ensembl
RGD
UniProt		 PMID:12397359 PMID:12624110 PMID:14672706 PMID:15147242 PMID:15193144 More... GO_REF:0000024 GO_REF:0000107 MGI:2388855 MGI:5297789 MGI:5306297 MGI:6282958 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 enables ISO
IEA		 (PMID:14672706), (PMID:15193144)
(MGI:2388855|PMID:12397359), (MGI:5297789|PMID:15147242), (MGI:5297791|PMID:12657651), (MGI:5306297|PMID:17487425)
GO_REF:0000107		 RGD
Ensembl		 PMID:12397359 PMID:12657651 PMID:14672706 PMID:15147242 PMID:15193144 More... GO_REF:0000107 MGI:2388855 MGI:5297789 MGI:5297791 MGI:5306297 NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 enables ISO
ISS
IEA		 (PMID:12738229), (PMID:23785138)
GO_REF:0000024
(MGI:4410413|PMID:19605937), (MGI:4820700|PMID:20106950), (MGI:5568140|PMID:24736997)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:12738229 PMID:19605937 PMID:20106950 PMID:23785138 PMID:24736997 GO_REF:0000024 GO_REF:0000107 MGI:4410413 MGI:4820700 MGI:5568140 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 enables ISO (PMID:12738229)
(MGI:4410413|PMID:19605937)		 RGD PMID:12738229 PMID:19605937 MGI:4410413 NCBI chr 4:179,699,432...179,747,710
Ensembl chr 4:179,699,502...179,746,949 		JBrowse link
G Ciart circadian associated repressor of transcription enables ISO (MGI:5568140|PMID:24736997) RGD PMID:24736997 MGI:5568140 NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313 		JBrowse link
G Clock clock circadian regulator enables IEA
ISO
ISS
IBA		 GO_REF:0000107
(PMID:18411297), (PMID:23785138)
GO_REF:0000024
(MGI:4410413|PMID:19605937), (MGI:4820700|PMID:20106950), (MGI:4837055|PMID:20430893), (MGI:5553247|PMID:12738229), (MGI:6282958|PMID:30012868)
GO_REF:0000033		 Ensembl
RGD
UniProt
GO_Central		 PMID:12738229 PMID:18411297 PMID:19605937 PMID:20106950 PMID:20430893 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:4410413 MGI:4820700 MGI:4837055 MGI:5553247 MGI:6282958 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 enables ISO (MGI:5009503|PMID:19129230), (MGI:5292598|PMID:21768648), (MGI:5464222|PMID:23133559), (MGI:5545849|PMID:24385426) RGD PMID:19129230 PMID:21768648 PMID:23133559 PMID:24385426 MGI:5009503 MGI:5292598 MGI:5464222 MGI:5545849 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Figla folliculogenesis specific bHLH transcription factor contributes_to ISO UniProtKB:P15923-1 (PMID:15044608) RGD PMID:15044608 NCBI chr 4:118,432,517...118,436,846
Ensembl chr 4:118,432,765...118,436,690 		JBrowse link
G Gata3 GATA binding protein 3 enables ISO (PMID:20855495) RGD PMID:20855495 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 contributes_to
enables		 ISO
IEA		 (MGI:4362015|PMID:11812799)
(PMID:15486975)
GO_REF:0000107
(PMID:20144608)		 RGD
Ensembl		 PMID:11812799 PMID:15486975 PMID:20144608 GO_REF:0000107 MGI:4362015 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hdac1 histone deacetylase 1 enables ISO (MGI:5568140|PMID:24736997) RGD PMID:24736997 MGI:5568140 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
(MGI:1859234|PMID:10851137)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:10851137 PMID:19670267 GO_REF:0000033 GO_REF:0000107 MGI:1859234, RGD:9685170 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha enables IEA
ISO		 GO_REF:0000107
(MGI:5528778|PMID:24011070)		 Ensembl
RGD		 PMID:24011070 GO_REF:0000107 MGI:5528778 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Max MYC associated factor X enables ISO (PMID:16171389) RGD PMID:16171389 NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137 		JBrowse link
G Mitf melanocyte inducing transcription factor enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:27889061)
(MGI:5461240|PMID:23207919)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23207919 PMID:27889061 GO_REF:0000024 GO_REF:0000107 MGI:5461240 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Mybbp1a MYB binding protein 1a enables ISO
IEA		 UniProtKB:O08785|UniProtKB:P97784 (MGI:5009503|PMID:19129230)
GO_REF:0000107		 RGD
Ensembl		 PMID:19129230 GO_REF:0000107 MGI:5009503 NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor enables ISS
ISO		 GO_REF:0000024
(PMID:19545562)
(PMID:18818310), (PMID:27791094)		 UniProt
RGD		 PMID:18818310 PMID:19545562 PMID:27791094 GO_REF:0000024 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myod1 myogenic differentiation 1 enables IDA
ISS
ISO		 GO_REF:0000024
(MGI:1934945|PMID:10652346), (MGI:5508271|PMID:15706034)		 UniProt
RGD		 PMID:10652346 PMID:15706034 PMID:11600477 GO_REF:0000024 MGI:1934945 MGI:5508271, RGD:9686083 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin enables ISS
ISO
IEA		 GO_REF:0000024
(MGI:5009475|PMID:19783823), (MGI:5508271|PMID:15706034), (MGI:5526919|PMID:22847234)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15706034 PMID:19783823 PMID:22847234 GO_REF:0000024 GO_REF:0000107 MGI:5009475 MGI:5508271 MGI:5526919 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Neurod1 neuronal differentiation 1 enables ISO
IBA		 (PMID:14752053)
(MGI:2686763|PMID:14697366)
GO_REF:0000033		 RGD
GO_Central		 PMID:14697366 PMID:14752053 GO_REF:0000033 MGI:2686763 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649 		JBrowse link
G Neurod2 neuronal differentiation 2 enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(MGI:2686763|PMID:14697366), (MGI:3789797|PMID:18214987)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:14697366 PMID:18214987 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:2686763 MGI:3789797 NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986 		JBrowse link
G Neurod4 neuronal differentiation 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030 		JBrowse link
G Neurod6 neuronal differentiation 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:84,846,659...84,849,905
Ensembl chr 4:84,846,231...84,849,999 		JBrowse link
G Neurog1 neurogenin 1 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:20102160)
(MGI:2686763|PMID:14697366)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:14697366 PMID:20102160 GO_REF:0000024 GO_REF:0000033 MGI:2686763 NCBI chr17:8,362,878...8,364,397
Ensembl chr17:8,362,821...8,364,571 		JBrowse link
G Neurog2 neurogenin 2 enables ISO
IBA		 (MGI:2686763|PMID:14697366)
GO_REF:0000033		 RGD
GO_Central		 PMID:14697366 GO_REF:0000033 MGI:2686763 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Neurog3 neurogenin 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:30,079,780...30,081,262
Ensembl chr20:30,079,780...30,081,262 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 enables IEA
ISO
ISS		 GO_REF:0000107
(MGI:3819720|PMID:18565334)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:18565334 GO_REF:0000024 GO_REF:0000107 MGI:3819720 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Olig1 oligodendrocyte transcription factor 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:30,514,379...30,516,521
Ensembl chr11:30,514,379...30,516,521 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149 		JBrowse link
G Per1 period circadian regulator 1 enables ISO
IEA		 (PMID:18411297)
GO_REF:0000107		 RGD
Ensembl		 PMID:18411297 GO_REF:0000107 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma enables ISS
ISO		 GO_REF:0000024
(MGI:3830801|PMID:19041764)		 UniProt
RGD		 PMID:19041764 GO_REF:0000024 MGI:3830801 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables ISO (MGI:5464222|PMID:23133559) RGD PMID:23133559 MGI:5464222 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Ptf1a pancreas associated transcription factor 1a enables ISO (PMID:22232429) RGD PMID:22232429 NCBI chr17:82,051,281...82,053,135
Ensembl chr17:82,051,281...82,053,135 		JBrowse link
G Scx scleraxis bHLH transcription factor contributes_to
enables		 ISO (PMID:10775504)
(MGI:5294531|PMID:19828133)
(MGI:4418577|PMID:20059955), (MGI:72077|PMID:7743923)		 RGD PMID:7743923 PMID:10775504 PMID:19828133 PMID:20059955 MGI:4418577 MGI:5294531 MGI:72077 NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626 		JBrowse link
G Snai1 snail family transcriptional repressor 1 enables ISO (PMID:11912130) RGD PMID:11912130 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 enables ISO (PMID:11912130), (PMID:15737616), (PMID:16707493) RGD PMID:11912130 PMID:15737616 PMID:16707493 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Spz1 spermatogenic leucine zipper 1 enables ISO (PMID:30541061) RGD PMID:30541061 NCBI chr 2:23,796,741...23,798,337
Ensembl chr 2:23,796,742...23,798,337 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 enables IEA
ISO		 GO_REF:0000107
(PMID:15358760)		 Ensembl
RGD		 PMID:15358760 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor enables ISO (PMID:20855495)
(PMID:18550854)		 RGD PMID:18550854 PMID:20855495 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976 		JBrowse link
G Tcf12 transcription factor 12 enables ISS
ISO		 GO_REF:0000024
(MGI:3789797|PMID:18214987)		 UniProt
RGD		 PMID:18214987 GO_REF:0000024 MGI:3789797 NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201 		JBrowse link
G Tcf15 transcription factor 15 enables ISO (MGI:6508495|PMID:15226298) RGD PMID:15226298 MGI:6508495 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766 		JBrowse link
G Tcf21 transcription factor 21 enables ISS
ISO		 GO_REF:0000024
UniProtKB:O35437 (MGI:1203942|PMID:9545521), (MGI:3588448|PMID:15919722)		 UniProt
RGD		 PMID:9545521 PMID:15919722 GO_REF:0000024 MGI:1203942 MGI:3588448 NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202 		JBrowse link
G Tcf3 transcription factor 3 contributes_to
enables		 IDA
ISO
ISS
IEA		 PMID:19828133
(PMID:10775504)
GO_REF:0000024
(PMID:10652346), (PMID:7933101)
GO_REF:0000107
UniProtKB:Q6QHK4 (PMID:15044608)
(MGI:4362015|PMID:11812799)
UniProtKB:O35437 (MGI:1203942|PMID:9545521), (MGI:3789797|PMID:18214987), (MGI:6508495|PMID:15226298), (PMID:30541061)		 RGD
UniProt
Ensembl		 PMID:7933101 PMID:9545521 PMID:10652346 PMID:10775504 PMID:11812799 More... GO_REF:0000024 GO_REF:0000107 MGI:1203942 MGI:3789797 MGI:4362015 MGI:6508495, RGD:8553796 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tcf4 transcription factor 4 enables ISS
ISO		 GO_REF:0000024
(MGI:3789797|PMID:18214987), (MGI:85411|PMID:8978694)		 UniProt
RGD		 PMID:8978694 PMID:18214987 GO_REF:0000024 MGI:3789797 MGI:85411 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tfap4 transcription factor AP-4 enables ISO (PMID:11171123), (PMID:12663744), (PMID:18818310), (PMID:19505873), (PMID:7933101)
(MGI:4456960|PMID:11171123)		 RGD PMID:7933101 PMID:11171123 PMID:12663744 PMID:18818310 PMID:19505873 MGI:4456960 NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 enables ISO (MGI:7510300|PMID:20713358) RGD PMID:20713358 MGI:7510300 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 enables ISO (PMID:17332325), (PMID:20804746)
(MGI:3623529|PMID:16502419), (MGI:4838344|PMID:20804746), (MGI:5528778|PMID:24011070)		 RGD PMID:16502419 PMID:17332325 PMID:20804746 PMID:24011070 MGI:3623529 MGI:4838344 MGI:5528778 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:4830798|PMID:20346398), (MGI:7510300|PMID:20713358)		 Ensembl
UniProt
RGD		 PMID:20346398 PMID:20713358 GO_REF:0000024 GO_REF:0000107 MGI:4830798 MGI:7510300 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    binding 17534
      organic cyclic compound binding 6113
        nucleic acid binding 3845
          transcription regulatory region nucleic acid binding 1300
            transcription cis-regulatory region binding 1295
              RNA polymerase II transcription regulatory region sequence-specific DNA binding 1189
                RNA polymerase II cis-regulatory region sequence-specific DNA binding 1020
                  E-box binding 58
Path 2
Term Annotations click to browse term
  molecular_function 20483
    binding 17534
      organic cyclic compound binding 6113
        nucleic acid binding 3845
          DNA binding 2287
            sequence-specific DNA binding 1468
              sequence-specific double-stranded DNA binding 1358
                transcription cis-regulatory region binding 1295
                  RNA polymerase II transcription regulatory region sequence-specific DNA binding 1189
                    RNA polymerase II cis-regulatory region sequence-specific DNA binding 1020
                      E-box binding 58
paths to the root