Bhlhe23 (basic helix-loop-helix family, member e23) - Rat Genome Database

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Gene: Bhlhe23 (basic helix-loop-helix family, member e23) Rattus norvegicus
Analyze
Symbol: Bhlhe23
Name: basic helix-loop-helix family, member e23
RGD ID: 1559760
Description: Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Predicted to be involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of retinal cell programmed cell death; post-embryonic eye morphogenesis; and retinal rod cell development. Predicted to be active in nucleus. Orthologous to human BHLHE23 (basic helix-loop-helix family member e23); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basic helix-loop-helix domain containing, class B4; Bhlhb4; class E basic helix-loop-helix protein 23; LOC499952; RGD1559760; similar to basic helix-loop-helix transcriptional regulator beta4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,266,572 - 188,268,786 (-)NCBIGRCr8
mRatBN7.23167,889,009 - 167,891,223 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,889,009 - 167,891,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,268,753 - 172,270,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,227,851 - 181,230,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,889,943 - 177,892,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,279,997 - 176,282,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,279,997 - 176,282,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03179,978,577 - 179,980,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,886,343 - 169,888,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,692,856 - 164,695,070 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11863370   PMID:15363390   PMID:17255172  


Genomics

Comparative Map Data
Bhlhe23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,266,572 - 188,268,786 (-)NCBIGRCr8
mRatBN7.23167,889,009 - 167,891,223 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,889,009 - 167,891,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,268,753 - 172,270,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,227,851 - 181,230,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,889,943 - 177,892,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,279,997 - 176,282,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,279,997 - 176,282,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03179,978,577 - 179,980,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,886,343 - 169,888,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,692,856 - 164,695,070 (+)NCBICelera
Cytogenetic Map3q43NCBI
BHLHE23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,005,927 - 63,006,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,005,927 - 63,007,035 (-)EnsemblGRCh38hg38GRCh38
GRCh372061,637,279 - 61,638,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,107,846 - 61,108,787 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,107,846 - 61,108,787NCBI
Celera2058,313,980 - 58,315,036 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,354,584 - 58,355,640 (-)NCBIHuRef
CHM1_12061,538,035 - 61,539,091 (-)NCBICHM1_1
T2T-CHM13v2.02064,806,267 - 64,807,304 (-)NCBIT2T-CHM13v2.0
Bhlhe23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,416,174 - 180,418,693 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,416,174 - 180,418,693 (-)EnsemblGRCm39 Ensembl
GRCm382180,774,381 - 180,776,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,774,381 - 180,776,900 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,509,086 - 180,511,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,704,066 - 180,706,308 (-)NCBIMGSCv36mm8
Celera2184,860,531 - 184,863,050 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.34NCBI
Bhlhe23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555281,094,234 - 1,094,674 (+)NCBIChiLan1.0ChiLan1.0
BHLHE23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,789,672 - 68,792,505 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12068,783,116 - 68,785,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,385,608 - 59,392,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12060,681,496 - 60,681,988 (-)NCBIpanpan1.1PanPan1.1panPan2
BHLHE23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,791,368 - 46,792,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,975,704 - 45,976,372 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,663,555 - 47,669,166 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.02446,884,708 - 46,885,377 (-)NCBIUNSW_CanFamBas_1.0
BHLHE23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,227,916 - 62,228,638 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,217,583 - 62,228,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BHLHE23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121,215,909 - 1,221,960 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21,216,206 - 1,216,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605049,005,375 - 49,006,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474128,766,303 - 28,766,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474128,762,079 - 28,766,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:96
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000013690
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 4 94 5 4 1 7 1 6 22 11 88 9 46 3

Sequence


Ensembl Acc Id: ENSRNOT00000013690   ⟹   ENSRNOP00000013690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,889,009 - 167,891,223 (-)Ensembl
Rnor_6.0 Ensembl3176,279,997 - 176,282,211 (-)Ensembl
RefSeq Acc Id: NM_001109211   ⟹   NP_001102681
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,266,572 - 188,268,786 (-)NCBI
mRatBN7.23167,889,009 - 167,891,223 (-)NCBI
Rnor_6.03176,279,997 - 176,282,211 (-)NCBI
Rnor_5.03179,978,577 - 179,980,791 (-)NCBI
RGSC_v3.43169,886,343 - 169,888,557 (-)RGD
Celera3164,692,856 - 164,695,070 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88785 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013690.2
RefSeq Acc Id: NP_001102681   ⟸   NM_001109211
- UniProtKB: D3ZU26 (UniProtKB/TrEMBL),   A6KM77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013690   ⟸   ENSRNOT00000013690
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU26-F1-model_v2 AlphaFold D3ZU26 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559760 AgrOrtholog
BioCyc Gene G2FUF-46320 BioCyc
Ensembl Genes ENSRNOG00000010312 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013690.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_transcription_factors UniProtKB/TrEMBL
  HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:499952 UniProtKB/TrEMBL
NCBI Gene 499952 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/TrEMBL
  PTHR19290:SF53 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Bhlhe23 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010312 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A6KM77 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-19 Bhlhe23  basic helix-loop-helix family, member e23  Bhlhb4  basic helix-loop-helix domain containing, class B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Bhlhb4  basic helix-loop-helix domain containing, class B4  RGD1559760_predicted  similar to basic helix-loop-helix transcriptional regulator beta4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559760_predicted  similar to basic helix-loop-helix transcriptional regulator beta4 (predicted)  LOC499952  similar to basic helix-loop-helix transcriptional regulator beta4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499952  similar to basic helix-loop-helix transcriptional regulator beta4      Symbol and Name status set to provisional 70820 PROVISIONAL