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Gene: Bhlha15 (basic helix-loop-helix family, member a15) Rattus norvegicus

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Symbol:

Bhlha15

Name:

basic helix-loop-helix family, member a15

RGD ID:

3091

Description:

Enables DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Predicted to act upstream of or within several processes, including cell-cell adhesion mediated by cadherin; intracellular distribution of mitochondria; and type B pancreatic cell maturation. Located in nucleus. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

basic helix-loop-helix domain containing, class B, 8; basic helix-loop-helix transcription factor (bHlH); bHlH; Bhlhb8; class A basic helix-loop-helix protein 15; class B basic helix-loop-helix protein 8; MIST-1; Mist1; muscle, intestine and stomach expression 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,534,123 - 15,538,299 (-)	NCBI		GRCr8
mRatBN7.2	12	10,420,465 - 10,424,641 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,420,467 - 10,424,713 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	11,227,709 - 11,231,885 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	11,851,005 - 11,855,181 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	10,874,437 - 10,878,619 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,403,385 - 12,409,103 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,403,385 - 12,407,561 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	14,455,040 - 14,459,246 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	10,747,865 - 10,752,041 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	10,777,792 - 10,781,969 (-)	NCBI
Celera	12	12,219,590 - 12,223,766 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aldrin (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorohydrocarbon (EXP)

choline (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

coumarin (EXP)

cyclosporin A (ISO)

DDD (ISO)

DDE (ISO)

DDT (ISO)

dicrotophos (ISO)

dieldrin (ISO)

endosulfan (EXP)

endrin (ISO)

folic acid (ISO)

furan (EXP)

gamma-hexachlorocyclohexane (ISO)

genistein (ISO)

gentamycin (EXP)

glyphosate (EXP)

L-methionine (ISO)

methapyrilene (EXP)

methylmercury chloride (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pioglitazone (ISO)

pravastatin (EXP,ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (EXP)

sodium dichromate (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (EXP,ISO)

trichloroethene (EXP,ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

XL147 (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon development (IBA)

calcium-mediated signaling (ISO)

cell differentiation (ISO)

cell-cell adhesion mediated by cadherin (ISO)

cell-cell junction organization (ISO)

cell-cell signaling (ISO)

cellular response to glucose starvation (ISO,ISS)

endoplasmic reticulum unfolded protein response (ISO,ISS)

establishment of localization in cell (ISO)

G protein-coupled receptor signaling pathway (ISO)

glandular epithelial cell maturation (ISO)

glucose homeostasis (ISO)

Golgi organization (ISO)

intracellular distribution of mitochondria (ISO)

localization of cell (ISO)

mitochondrial calcium ion transmembrane transport (ISO)

negative regulation of myotube differentiation (ISO,ISS)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

sensory organ development (IBA)

type B pancreatic cell maturation (ISO)

Cellular Component

nucleus (IBA,IDA,ISO)

Molecular Function

DNA binding (IDA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

E-box binding (IBA)

identical protein binding (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

maturity-onset diabetes of the young pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern.	Lemercier C, etal., Dev Biol 1997 Feb 1;182(1):101-13.
4.	The rat Mist1 gene: structure and promoter characterization.	Lemercier C, etal., Gene 2000 Jan 25;242(1-2):209-18.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:11696558	PMID:12829745	PMID:12921743	PMID:15024058	PMID:15112319	PMID:15489334	PMID:15665001	PMID:16423820	PMID:17605298	PMID:17612490

Genomics

Comparative Map Data

Bhlha15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,534,123 - 15,538,299 (-)	NCBI		GRCr8
mRatBN7.2	12	10,420,465 - 10,424,641 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,420,467 - 10,424,713 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	11,227,709 - 11,231,885 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	11,851,005 - 11,855,181 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	10,874,437 - 10,878,619 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,403,385 - 12,409,103 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,403,385 - 12,407,561 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	14,455,040 - 14,459,246 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	10,747,865 - 10,752,041 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	10,777,792 - 10,781,969 (-)	NCBI
Celera	12	12,219,590 - 12,223,766 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

BHLHA15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	98,211,439 - 98,215,457 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	98,211,439 - 98,215,457 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	97,840,751 - 97,844,769 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	97,679,502 - 97,680,207 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	97,486,254 - 97,486,842	NCBI
Celera	7	92,535,465 - 92,536,170 (+)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	92,442,435 - 92,443,140 (+)	NCBI		HuRef
CHM1_1	7	97,771,610 - 97,772,315 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	99,441,577 - 99,445,595 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	97,166,444 - 97,167,149 (+)	NCBI

Bhlha15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	144,127,104 - 144,131,259 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	144,127,104 - 144,131,259 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	144,190,286 - 144,194,441 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	144,190,286 - 144,194,441 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	144,951,155 - 144,955,310 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	144,443,813 - 144,447,968 (+)	NCBI		MGSCv36	mm8
Celera	5	141,174,663 - 141,178,820 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	83.05	NCBI

Bhlha15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	14,103,053 - 14,106,714 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955460	14,103,053 - 14,106,714 (+)	NCBI	ChiLan1.0	ChiLan1.0

BHLHA15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	116,057,828 - 116,061,791 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	164,322,479 - 164,326,423 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	6,306,929 - 6,311,026 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	103,676,211 - 103,680,153 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	103,677,022 - 103,677,593 (+)	Ensembl	panpan1.1		panPan2

BHLHA15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	11,112,233 - 11,115,776 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	11,114,694 - 11,115,257 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	12,738,597 - 12,742,381 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	11,112,675 - 11,116,461 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	10,981,367 - 10,985,151 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	10,961,184 - 10,964,967 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	11,195,228 - 11,199,013 (-)	NCBI		UU_Cfam_GSD_1.0

Bhlha15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	139,188,655 - 139,192,549 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936750	753,615 - 754,187 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936750	752,887 - 756,562 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BHLHA15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	5,410,518 - 5,414,072 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	5,410,467 - 5,414,074 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	5,464,958 - 5,473,366 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BHLHA15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	14,953,483 - 14,957,674 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	14,956,095 - 14,956,679 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	1,119,815 - 1,123,886 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bhlha15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	31,672,397 - 31,674,205 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	31,671,820 - 31,676,045 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bhlha15
11 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	414
Count of miRNA genes:	226
Interacting mature miRNAs:	283
Transcripts:	ENSRNOT00000037251
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	9318216	12829686	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	6833190	17870186	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat

Markers in Region

D12Wox29

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,426,000 - 10,426,267 (+)	MAPPER	mRatBN7.2
mRatBN7.2	12	10,426,164 - 10,426,267 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,409,085 - 12,409,366	NCBI	Rnor6.0
Rnor_6.0	12	12,409,266 - 12,409,366	NCBI	Rnor6.0
Rnor_5.0	12	14,460,921 - 14,461,021	UniSTS	Rnor5.0
Rnor_5.0	12	14,460,740 - 14,461,021	UniSTS	Rnor5.0
RGSC_v3.4	12	10,753,565 - 10,753,665	UniSTS	RGSC3.4
Celera	12	12,225,290 - 12,225,388	UniSTS
Cytogenetic Map	12	p11	UniSTS

D12Wox19

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,423,273 - 10,423,429 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,406,194 - 12,406,349	NCBI	Rnor6.0
Rnor_5.0	12	14,457,849 - 14,458,004	UniSTS	Rnor5.0
RGSC_v3.4	12	10,750,674 - 10,750,829	UniSTS	RGSC3.4
Celera	12	12,222,399 - 12,222,554	UniSTS
Cytogenetic Map	12	p11	UniSTS

D12Wox20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	15,536,039 - 15,536,327 (+)	Marker Load Pipeline
mRatBN7.2	12	10,422,381 - 10,422,669 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,405,302 - 12,405,589	NCBI	Rnor6.0
Rnor_5.0	12	14,456,957 - 14,457,244	UniSTS	Rnor5.0
RGSC_v3.4	12	10,749,782 - 10,750,069	UniSTS	RGSC3.4
Celera	12	12,221,507 - 12,221,794	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	43	113	91	90	59	25	59	6	210	89	93	45	59	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF049874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U58279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037251 ⟹ ENSRNOP00000035219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	10,420,467 - 10,424,713 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,403,385 - 12,407,561 (-)	Ensembl

RefSeq Acc Id:

NM_012863 ⟹ NP_036995

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,534,123 - 15,538,299 (-)	NCBI
mRatBN7.2	12	10,420,465 - 10,424,641 (-)	NCBI
Rnor_6.0	12	12,403,385 - 12,407,561 (-)	NCBI
Rnor_5.0	12	14,455,040 - 14,459,246 (-)	NCBI
RGSC_v3.4	12	10,747,865 - 10,752,041 (-)	RGD
Celera	12	12,219,590 - 12,223,766 (-)	RGD

Sequence:

show sequence

GCCTGTGGTGGCTAAAGCGACGTGTCCTTGTCCCCCGAGGGCAGCCTCTGCGCGTACGGCCTCG
GATCCCCAGTCGGAAGGGCCTCTCCCAGCCACCACCTCCTGGGAAAAACAGCCTAGAGCTATGA
AGACCAAGAACCGGCCCCCTCGGCGCCGGACACCCATGCAGGACGCAGAAGCCACCCCAGGAGA
GCAGACGCCTGACAGATCCCAGTCAGGCTCAGGGGCATCAGAAGTGACCAAGGGTCTTCGGAGC
AGGACAGCCCGTGCGAGCGGAACTCGGGCAGAGGTCAGCCGCCGGCGACAGGGGTCCAGCAGCC
GCAGGGAGAACAGCGTTCAGAGGCGGCTGGAGAGCAATGAGCGAGAAAGACAACGGATGCACAA
ACTGAACAATGCTTTCCAGGCGCTGCGGGAGGTCATCCCGCATGTGCGGGCTGACAAGAAGCTC
TCCAAGATCGAGACCCTCACACTGGCCAAGAACTATATCAAGTCGCTGACAGCCACCATACTTA
CTATGTCCAGCAGCCGCCTCCCGGGGCTGGAGGCGCCAGGTCCTGCGCCAGGCCCTAAATTGTA
CCAGCATTACCATCACCAGCAGCAGCAACAGCAGCAGCAGCAGCAGGTGGCTGGGGCCGTGCTC
GGTGTCACCGAGGACCAGCCTCAAGGCCACCTGCAACGATACTCTACACAGATCCACAGCTTCA
GAGAGGGGAGCTAGCACGTGCTTCGGGCTTCCGGTGTGCCTTGGCAGTGGTGACCCGGCCTGCT
CATCTCAGCTGTGGTCCCTCTAGGCCACAAGCCCCAGACTGGTAATGACACTACTGAGATCGTG
GAGGGGATTTTGTTGTTGATGAAAGCTCTTGAGAGGCCCCAGCCGCTTTGAACTCCTAATCCTC
CTCACCTCCATCTTCTCTAGGGCTGGGACTACATCATTATATGGTGCCACGCTGGGGACTAAAC
TAAGGGCTGTCTGTGGGCTAAGCAGGCACCCTACCAACTGAGCTGCATTCCCAGCCCAAGGCTG
ACTTCGGTGACTCCATTTTCCTCCAAAGTCAGCTCAGACACGAACATGTGGCAGTTTTTTCCTA
GCCACCCAAAGGACAAGGGAGTGATCTGGGCCTTCGAGGTATATCAAGGCCCAAAGCTCCAGAG
AAAGCCTACCTGTCCTTACTGCCTTTTGACAAAGGGTGGGCAGGGTGGGAGAGTTCTTGCCTTC
CTTATGATTCATGTGTGGCCGGTGAGGGATGATTCCAGGGAAAACCTTACTTACAAATGTCCCT
GCTACTGCTGAGCCTAAGGTCCGTCCCATATTGTGGGGCTACGGGAAATTGGACCCAAAGTGCC
ACTCAATCCCCTCAGGGAATATATGGCAAAACCAAGTGGTGTCTCATTTTATAGGATTGCCCTG
GGCCCAATTTAACAACTGAAGTCAGAAAGGCCTAGCCAATCCCATAGGACTTTAATAAGGTCGG
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCCTCCCTCCCTCTCTCTCCCTC
CCTTCCTCCCTCCCCCCACCCCAAAATGGAGGTCACATGTGGATGACCTCATACAGTGCCTGGA
GACTTCTGGAAAAGCTGCAGTGTCCTAGGCTGTGGCTGACCACGACCTAACCCTAAGATATGAG
GGCCCTGTGCGGAGATCAGGCAGACCCTTGAGGCTCTGTACAAAGAGAGACTTCTCGCTGTGTC
CCCTCTCCATTACAGGGGAACCCCCATTCTTGGTATTTCACGTTCTTCTTGGTTAGCCCGATGT
ATGGCTGCCATGTGTTCCCTCACGAGCCGCTTGGACTTAGCTCTTGGTACCTTTGGTGTTTTCT
CTGAGGCAGAAGCTGGAGTGACAGGCATGTCCCTCCCCCGACCGGCTCATAAATAAGGAGGGCT
GAGTGGTTGGCAGCCTGGCTGCTCGAGCTTCCGTCCCCGGGCGTTCCTGCCCCACTGGCTCTGA
CAGGCTTCACTACTTTGCTGTCAGTTGTTCCTTGGCCTCTTCCTTCCTCCCTTGTCTCTCTGCC
CAGAACTAACCTGGAGTTCCTTCAGGGGCTCATACCTCCACCCCCACCTTTAGAATGACAGGAG
TCTCGCTATGTAGCTCAGGCTGGCCCGAAACTGATTTTTTGAACTTGTGCTTGGTCCATCCTCC
TGCTCCAGCCCCTCCCTCTGCCCCCAAGTGTTGTGAACGCAGGATAGGGAGAGAGCCCTGGCAC
CCGAAGAAATAGATAAAGGCTAGATTAGGCCTGGGCGCGTTGGTCCCCTCATCCAGTGAGACTT
GATCTGTAGCACTCTCCAGTCCTGGAGAGCTGGTCTGGACCCTTCACGGATCACACTCAGGCCA
GGTGGCGACTAAGGGCCTGTGTGTTCCTCAGGGACGGCTACTGGGAAAGGTCAATAGTCAGGGA
ATTCACCAGTGTGAGCAGAAGCCAGGCACAACTCCAAGTTGGAAAGGCAGAGACCCAGATATCT
ACCTTGCTAGGGGGGACCTGCCCAGTGGAACACAGAGGCCTCTGCCGACAGACAGTGGCTGGCT
TCCACATGAGACCGAGGCCAGAGCTGGGCTCCTTTTGTCCGACCTTGCAGGAAGCACAGGGGAA
GGAAGCTGTCCGCCCAAACTTCTGCCCTAATGCCTGGCTACAGCCCAGGGCCTGTCCAGGTTCA
CTGTTTGGTAGGGCCACAACCTCGTGGCTCTTTGTCCCCCGTTAGCTGTCCAGTTCTTTAACTG
GTGACACAGGACCTAGATGTCCCTGGGCCATATCAAAGGGTCTTTAGGGACTCCAGTCCCACTA
GGAGGCTAGGACAAGTCTGTGATACCAGGAAGTCCTGTTGCTCTGTCTCCCTGTTCCAACCAGG
GTGATCCTTTTTTGGAACTGGAGCATAGGTTGACCTCTAACTTACTACGTGGGGGAGGACGATG
AACTTCTGCCTTTATCTGTTGTGCTGGGGCTGATTAGAGGTAGGCATTCCACATCCAGTTTAGA
CAGGGCTGGGGCTTGAAGCCAGGGCTCGGAGCATCCTCAGTAACTACTCTACACCCCTAGTGTG
GTCTCTTCTGTCCTGCTGGGTAACGGGGCTGGGTTTATTCAAGCCCCTGGGAAGGGCTGGAGCC
GCCCCTCCACCTGTGCACCTAGGATTGAGGCCCAGTGTGGAGAACCAGCAGGGCCTTTATGAAG
AAGACCCTGGAGAGACTTTGTCCTAAGCCTCCAGATCTCACCGACTTCACATGGGCTCAAGCAG
AGAAACCTGAAGTGCAACCTGTCAGGGAAAAGCCATGATGAACAGCAGGGCCTGCGTCTTGCCT
GTCACCGCGGTGAAGACGTTCCTTAAATTACCTGGTTTTTCTCCCCCTAGTCCCCTCAGAGCAC
TAATGAAATTGTCAGCTGTATATCTTAAAGTGAAAAGATTTCACGGCCACTGTGCTCTGGTCTG
AGGAACAGGTGCCTGGAGACCTGCGCCTTTTTTAACATAAATGACTAATAAAAATCCGCCAGTC
ATAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036995	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53111	(Get FASTA)	NCBI Sequence Viewer
	AAF17707	(Get FASTA)	NCBI Sequence Viewer
	AAH61868	(Get FASTA)	NCBI Sequence Viewer
	EDL89638	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035219.5
GenBank Protein	P70562	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036995 ⟸ NM_012863
- UniProtKB:	P70562 (UniProtKB/Swiss-Prot), A6K1I0 (UniProtKB/TrEMBL), A0A8L2QJ40 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTKNRPPRRRTPMQDAEATPGEQTPDRSQSGSGASEVTKGLRSRTARASGTRAEVSRRRQGSS SRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATI LTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAVLGVTEDQPQGHLQRYSTQIHS FREGS hide sequence

Ensembl Acc Id:

ENSRNOP00000035219 ⟸ ENSRNOT00000037251

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70562-F1-model_v2	AlphaFold	P70562	1-197	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698427

Promoter ID:

EPDNEW_R8952

Type:

initiation region

Name:

Bhlha15_1

Description:

basic helix-loop-helix family, member a15

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	12,407,519 - 12,407,579	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3091	AgrOrtholog
BioCyc Gene	G2FUF-20031	BioCyc
Ensembl Genes	ENSRNOG00000025164	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037251.6	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5598799	IMAGE-MGC_LOAD
InterPro	bHLH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	bHLH_transcription_factors	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25334	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72528	IMAGE-MGC_LOAD
NCBI Gene	25334	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bhlha15	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025164	RatGTEx
SMART	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC222251
UniProt	A0A8L2QJ40	ENTREZGENE, UniProtKB/TrEMBL
	A6K1I0	ENTREZGENE, UniProtKB/TrEMBL
	BHA15_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-19	Bhlha15	basic helix-loop-helix family, member a15	Bhlhb8	basic helix-loop-helix domain containing, class B, 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Bhlhb8	basic helix-loop-helix domain containing, class B, 8	Mist1	muscle, intestine and stomach expression 1	Symbol and Name updated	1299863	APPROVED
2002-06-10	Mist1	Basic helix-loop-helix transcription factor (bHlH)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binds to the DNA target sequence -CANNTG- (E-box)	633179
gene_product	member of basic helix-loop-helix transcription factor family	633179

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)