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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of MAP kinase activity
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Accession:GO:0043407 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
Synonyms:exact_synonym: down regulation of MAPK activity;   downregulation of MAPK activity;   negative regulation of mitogen activated protein kinase activity
 narrow_synonym: inhibition of MAPK activity


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negative regulation of MAP kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in IDA (PMID:19460854) UniProt PMID:19460854 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agt angiotensinogen involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Apoe apolipoprotein E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of ISO GO_Central GO_REF:0000119 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Cav1 caveolin 1, caveolae protein acts_upstream_of_or_within IMP (PMID:12388746) MGI PMID:12388746 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Cav3 caveolin 3 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833 		JBrowse link
G Cblc Casitas B-lineage lymphoma c involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:19,513,643...19,530,734
Ensembl chr 7:19,512,806...19,530,734 		JBrowse link
G Cd300a CD300A molecule involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322 		JBrowse link
G Dab2ip disabled 2 interacting protein involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Dusp7 dual specificity phosphatase 7 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 9:106,245,831...106,252,923
Ensembl chr 9:106,245,831...106,252,923 		JBrowse link
G Fem1a fem 1 homolog a acts_upstream_of_or_within IDA (PMID:18270204) MGI PMID:18270204 NCBI chr17:56,563,793...56,570,608
Ensembl chr17:56,563,810...56,570,610 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gstp-ps glutathione S-transferase, pi, pseudogene involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:191,758,036...191,762,461
Ensembl chr 1:191,758,120...191,758,750 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstp2 glutathione S-transferase, pi 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,090,288...4,092,221
Ensembl chr19:4,090,285...4,096,023 		JBrowse link
G Gstp3 glutathione S-transferase pi 3 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,107,470...4,109,587
Ensembl chr19:4,107,477...4,109,569 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase acts_upstream_of_or_within IGI (PMID:12409258), (PMID:16271875) MGI PMID:12409258 PMID:16271875 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hyal2 hyaluronoglucosaminidase 2 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:107,445,096...107,449,975
Ensembl chr 9:107,445,144...107,449,978 		JBrowse link
G Il1b interleukin 1 beta involved_in IDA (PMID:16865359) BHF-UCL PMID:16865359 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Inpp5k inositol polyphosphate 5-phosphatase K involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:75,519,893...75,539,691
Ensembl chr11:75,521,814...75,539,697 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in IMP
ISO		 (PMID:17379480) BHF-UCL
GO_Central		 PMID:17379480 GO_REF:0000119 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Kng2 kininogen 2 ISO in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr16:22,804,602...22,847,851
Ensembl chr16:22,804,604...22,848,232 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IMP (PMID:9252121) UniProt PMID:9252121 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Mir218-1 microRNA 218-1 involved_in ISO (PMID:21385766) BHF-UCL PMID:21385766 NCBI chr 5:48,381,284...48,381,393
Ensembl chr 5:48,381,284...48,381,393 		JBrowse link
G Mir218-2 microRNA 218-2 involved_in ISO (PMID:21385766) BHF-UCL PMID:21385766 NCBI chr11:35,507,643...35,507,752
Ensembl chr11:35,507,643...35,507,752 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within IMP
IGI		 (PMID:12409258), (PMID:16271875)
(PMID:10620616)
(PMID:11297510)		 MGI PMID:10620616 PMID:11297510 PMID:12409258 PMID:16271875 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nup62 nucleoporin 62 involved_in IMP (PMID:11489947) UniProt PMID:11489947 NCBI chr 7:44,465,512...44,481,260
Ensembl chr 7:44,465,512...44,480,236 		JBrowse link
G Obox4 oocyte specific homeobox 4 acts_upstream_of_or_within IMP (PMID:20154267) MGI PMID:20154267
G Paqr3 progestin and adipoQ receptor family member III acts_upstream_of_or_within ISO
IMP		 (PMID:17724343) MGI PMID:17724343 NCBI chr 5:97,229,223...97,259,608
Ensembl chr 5:97,230,188...97,259,455 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma acts_upstream_of_or_within ISO GO_Central GO_REF:0000119 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO GO_Central GO_REF:0000119 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within IMP (PMID:9064344), (PMID:9254656) MGI PMID:9064344 PMID:9254656 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO
IDA		 (PMID:12833140) GO_Central
UniProt		 PMID:12833140 GO_REF:0000119 NCBI chr 2:90,260,100...90,411,102
Ensembl chr 2:90,260,098...90,410,991 		JBrowse link
G Rgs14 regulator of G-protein signaling 14 involved_in IMP (PMID:20837545) UniProt PMID:20837545 NCBI chr13:55,517,269...55,532,504
Ensembl chr13:55,517,545...55,532,500 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in IMP (PMID:19127022) BHF-UCL PMID:19127022 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within IDA (PMID:16339969) MGI PMID:16339969 NCBI chr 3:37,694,096...37,698,748
Ensembl chr 3:37,694,096...37,698,747 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within IDA (PMID:16339969) MGI PMID:16339969 NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 acts_upstream_of_or_within IDA (PMID:16339969) MGI PMID:16339969 NCBI chr18:38,719,300...38,734,400
Ensembl chr18:38,719,300...38,734,468 		JBrowse link
G Stk38 serine/threonine kinase 38 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr17:29,189,854...29,226,979
Ensembl chr17:29,189,854...29,226,969 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated acts_upstream_of_or_within ISO
IDA
IMP		 (PMID:17681137) MGI PMID:17681137 NCBI chr 1:183,078,604...183,105,356
Ensembl chr 1:183,078,134...183,106,331 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149 		JBrowse link
G Dusp10 dual specificity phosphatase 10 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:15306813) MGI
GO_Central		 PMID:15306813 GO_REF:0000119 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in IDA (PMID:11959862) BHF-UCL PMID:11959862 NCBI chr 2:80,447,558...80,462,005
Ensembl chr 2:80,447,389...80,462,705 		JBrowse link
G Gstp-ps glutathione S-transferase, pi, pseudogene involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:191,758,036...191,762,461
Ensembl chr 1:191,758,120...191,758,750 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstp2 glutathione S-transferase, pi 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,090,288...4,092,221
Ensembl chr19:4,090,285...4,096,023 		JBrowse link
G Gstp3 glutathione S-transferase pi 3 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:4,107,470...4,109,587
Ensembl chr19:4,107,477...4,109,569 		JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 involved_in IMP (PMID:11034606) UniProt PMID:11034606 NCBI chr 2:104,256,826...104,324,834
Ensembl chr 2:104,256,826...104,324,791 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISO
ISS		 RGD
UniProt		 PMID:12064607 GO_REF:0000024 RGD:1299562 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
G Nppa natriuretic peptide type A involved_in ISO GO_Central GO_REF:0000119 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) involved_in ISO GO_Central GO_REF:0000119 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Serpinb3d serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D involved_in ISO (PMID:21383048) UniProt PMID:21383048 NCBI chr 1:107,005,893...107,011,210
Ensembl chr 1:107,005,897...107,011,236 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within IGI (PMID:19300477) MGI PMID:19300477 NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within IGI (PMID:19300477) MGI PMID:19300477 NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623 		JBrowse link
G Sfrp5 secreted frizzled-related sequence protein 5 acts_upstream_of_or_within IGI (PMID:19300477) MGI PMID:19300477 NCBI chr19:42,186,410...42,190,691
Ensembl chr19:42,186,410...42,190,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      signal transduction 6912
        negative regulation of signal transduction 1562
          negative regulation of intracellular signal transduction 808
            negative regulation of MAPK cascade 209
              negative regulation of MAP kinase activity 61
                negative regulation of JUN kinase activity 17
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13440
      regulation of biological process 13004
        regulation of cellular process 12619
          regulation of metabolic process 7028
            regulation of macromolecule metabolic process 6485
              regulation of protein metabolic process 2332
                regulation of protein modification process 1290
                  regulation of protein phosphorylation 1012
                    regulation of protein kinase activity 555
                      regulation of protein serine/threonine kinase activity 309
                        regulation of MAP kinase activity 190
                          negative regulation of MAP kinase activity 61
                            negative regulation of JUN kinase activity 17
paths to the root