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Gene: Spry4 (sprouty RTK signaling antagonist 4) Mus musculus
Symbol: Spry4
Name: sprouty RTK signaling antagonist 4
Description: Involved in cellular response to leukemia inhibitory factor and negative regulation of MAP kinase activity. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Is expressed in several structures, including alimentary system; embryo mesenchyme; germ layer; limb; and nervous system. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A030006O18Rik; sprouty homolog 4; sprouty homolog 4 (Drosophila); sprouty4; spry-4
Homo sapiens (human) : SPRY4 (sprouty RTK signaling antagonist 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spry4 (sprouty RTK signaling antagonist 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spry4 (sprouty RTK signaling antagonist 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRY4 (sprouty RTK signaling antagonist 4)
Canis lupus familiaris (dog) : SPRY4 (sprouty RTK signaling antagonist 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spry4 (sprouty RTK signaling antagonist 4)
Sus scrofa (pig) : SPRY4 (sprouty RTK signaling antagonist 4)
Chlorocebus sabaeus (green monkey) : SPRY4 (sprouty RTK signaling antagonist 4)
Heterocephalus glaber (naked mole-rat) : Spry4 (sprouty RTK signaling antagonist 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1838,586,247 - 38,601,415 (-)Ensembl
GRCm381838,586,247 - 38,601,347 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371838,745,919 - 38,760,922 (-)NCBIGRCm37mm9NCBIm37
MGSCv361838,712,239 - 38,727,242 (-)NCBImm8
Celera1839,928,878 - 39,943,870 (-)NCBICelera
Cytogenetic Map18 B3NCBI
cM Map1820.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Spry4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313287
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.