SPRY4 (sprouty RTK signaling antagonist 4) - Rat Genome Database

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Gene: SPRY4 (sprouty RTK signaling antagonist 4) Canis lupus familiaris
Analyze
Symbol: SPRY4
Name: sprouty RTK signaling antagonist 4
RGD ID: 12246313
Description: ENCODES a protein that exhibits protein kinase inhibitor activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); amenorrhea (ortholog); disorder of sexual development (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein sprouty homolog 4; sprouty homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,199,890 - 37,213,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,203,609 - 37,208,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha234,251,922 - 34,265,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,655,748 - 37,669,607 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,655,756 - 37,669,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,729,962 - 34,743,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0235,546,901 - 35,560,761 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0236,348,824 - 36,362,690 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPRY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,199,890 - 37,213,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,203,609 - 37,208,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha234,251,922 - 34,265,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,655,748 - 37,669,607 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,655,756 - 37,669,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,729,962 - 34,743,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0235,546,901 - 35,560,761 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0236,348,824 - 36,362,690 (-)NCBIUU_Cfam_GSD_1.0
SPRY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385142,310,430 - 142,325,021 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5142,310,427 - 142,326,455 (-)EnsemblGRCh38hg38GRCh38
GRCh375141,689,995 - 141,704,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365141,670,189 - 141,684,750 (-)NCBINCBI36Build 36hg18NCBI36
Build 345141,670,190 - 141,684,750NCBI
Celera5137,771,260 - 137,785,910 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5136,836,448 - 136,851,092 (-)NCBIHuRef
CHM1_15141,123,564 - 141,138,189 (-)NCBICHM1_1
T2T-CHM13v2.05142,841,037 - 142,855,632 (-)NCBIT2T-CHM13v2.0
Spry4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,719,300 - 38,734,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,719,300 - 38,734,468 (-)EnsemblGRCm39 Ensembl
GRCm381838,586,247 - 38,601,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1838,586,247 - 38,601,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,745,919 - 38,760,922 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,712,239 - 38,727,242 (-)NCBIMGSCv36mm8
Celera1839,928,878 - 39,943,870 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1820.5NCBI
Spry4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,687,633 - 30,702,546 (-)NCBIGRCr8
mRatBN7.21830,436,513 - 30,451,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,436,443 - 30,453,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1830,540,734 - 30,555,640 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01831,301,144 - 31,316,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01830,636,445 - 30,651,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01832,593,370 - 32,609,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,594,958 - 32,609,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,271,207 - 32,287,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,532,680 - 31,547,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11831,561,542 - 31,563,842 (-)NCBI
Celera1830,074,673 - 30,089,579 (-)NCBICelera
Cytogenetic Map18p11NCBI
Spry4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541511,489,439 - 11,504,247 (+)NCBIChiLan1.0ChiLan1.0
SPRY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24137,555,079 - 137,569,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15135,694,633 - 135,709,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05137,667,280 - 137,683,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15143,778,785 - 143,793,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5143,778,785 - 143,791,939 (-)Ensemblpanpan1.1panPan2
Spry4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,333,698 - 150,348,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650411,907,681 - 11,922,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650411,907,667 - 11,922,487 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2143,875,355 - 143,892,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12143,877,334 - 143,891,280 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22150,062,423 - 150,076,497 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12344,931,967 - 44,946,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603432,902,675 - 32,917,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247741,508,315 - 1,523,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPRY4
155 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 14 6 9 2
Low 5 5 8 6 6 6 6 6 6 7 1 4
Below cutoff 1

Sequence


RefSeq Acc Id: ENSCAFT00000010101   ⟹   ENSCAFP00000009370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl237,203,609 - 37,208,858 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031458   ⟹   ENSCAFP00845024634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl237,655,756 - 37,669,556 (-)Ensembl
RefSeq Acc Id: XM_005617324   ⟹   XP_005617381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1237,199,890 - 37,213,710 (-)NCBI
Dog10K_Boxer_Tasha234,251,922 - 34,265,782 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038469700   ⟹   XP_038325628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1234,729,962 - 34,743,810 (-)NCBI
RefSeq Acc Id: XM_038530477   ⟹   XP_038386405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0236,348,824 - 36,362,690 (-)NCBI
RefSeq Acc Id: XM_038594713   ⟹   XP_038450641
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0235,546,901 - 35,560,761 (-)NCBI
RefSeq Acc Id: XM_038658764   ⟹   XP_038514692
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0237,655,748 - 37,669,607 (-)NCBI
RefSeq Acc Id: XP_005617381   ⟸   XM_005617324
- UniProtKB: A0A8I3S2U6 (UniProtKB/TrEMBL),   A0A8P0PNK0 (UniProtKB/TrEMBL),   A0A8C0QD66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009370   ⟸   ENSCAFT00000010101
RefSeq Acc Id: XP_038325628   ⟸   XM_038469700
RefSeq Acc Id: XP_038450641   ⟸   XM_038594713
RefSeq Acc Id: XP_038514692   ⟸   XM_038658764
- UniProtKB: A0A8I3S2U6 (UniProtKB/TrEMBL),   A0A8P0PNK0 (UniProtKB/TrEMBL),   A0A8C0QD66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386405   ⟸   XM_038530477
- UniProtKB: A0A8C0M639 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024634   ⟸   ENSCAFT00845031458


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006250 Ensembl
  ENSCAFG00000055849 UniProtKB/TrEMBL
  ENSCAFG00030002706 UniProtKB/TrEMBL
  ENSCAFG00040006487 UniProtKB/TrEMBL
  ENSCAFG00845017769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000105275.1 UniProtKB/TrEMBL
  ENSCAFT00030005025.1 UniProtKB/TrEMBL
  ENSCAFT00040012079.1 UniProtKB/TrEMBL
  ENSCAFT00845031458 ENTREZGENE
  ENSCAFT00845031458.1 UniProtKB/TrEMBL
InterPro Sprouty UniProtKB/TrEMBL
KEGG Report cfa:487192 UniProtKB/TrEMBL
NCBI Gene SPRY4 ENTREZGENE
PANTHER PTHR12365:SF6 UniProtKB/TrEMBL
  SPROUTY UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PROSITE SPR UniProtKB/TrEMBL
UniProt A0A8C0M639 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QD66 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S2U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PNK0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46767 ENTREZGENE