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Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) Mus musculus
Symbol: Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Description: Exhibits SH3 domain binding activity and kinase binding activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Localizes to cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); rheumatoid arthritis (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22); INTERACTS WITH 4,4'-diaminodiphenylmethane; all-trans-retinoic acid; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70zpep; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 8; Ptpn8; tyrosine-protein phosphatase non-receptor type 22
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBImm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn22
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552858
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.