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Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) Mus musculus
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Symbol: Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Description: Exhibits SH3 domain binding activity and kinase binding activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Localizes to cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); rheumatoid arthritis (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22); INTERACTS WITH 4,4'-diaminodiphenylmethane; all-trans-retinoic acid; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70zpep; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 8; Ptpn8; tyrosine-protein phosphatase non-receptor type 22
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBImm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptpn22
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552858
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.