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Gene: Irak3 (interleukin-1 receptor-associated kinase 3) Mus musculus
Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
RGD ID: 1318854
Description: Exhibits ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of NF-kappaB transcription factor activity; and response to molecule of bacterial origin. Localizes to cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3); PARTICIPATES IN Toll-like receptor signaling pathway; interleukin-1 signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4833428C18Rik; AI563835; IL-1 receptor-associated kinase M; IRA; IRAK-3; IRAK-M
Homo sapiens (human) : IRAK3 (interleukin 1 receptor associated kinase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irak3 (interleukin-1 receptor-associated kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak3 (interleukin 1 receptor associated kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK3 (interleukin 1 receptor associated kinase 3)
Canis lupus familiaris (dog) : IRAK3 (interleukin 1 receptor associated kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak3 (interleukin 1 receptor associated kinase 3)
Sus scrofa (pig) : IRAK3 (interleukin 1 receptor associated kinase 3)
Chlorocebus sabaeus (African green monkey) : IRAK3 (interleukin 1 receptor associated kinase 3)
Heterocephalus glaber (naked mole-rat) : Irak3 (interleukin 1 receptor associated kinase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910119,977,553 - 120,038,035 (-)NCBI
GRCm3810120,141,648 - 120,202,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,141,648 - 120,202,130 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,578,710 - 119,638,593 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,544,714 - 119,604,597 (-)NCBImm8
Celera10122,502,683 - 122,562,840 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Irak3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318854
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.