Dusp7 (dual specificity phosphatase 7) - Rat Genome Database
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Gene: Dusp7 (dual specificity phosphatase 7) Mus musculus
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Symbol: Dusp7
Name: dual specificity phosphatase 7
RGD ID: 1550083
MGI Page MGI
Description: Predicted to have MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in inactivation of MAPK activity; peptidyl-threonine dephosphorylation; and peptidyl-tyrosine dephosphorylation. Predicted to localize to cytosol. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human DUSP7 (dual specificity phosphatase 7); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-amphetamine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU015694; dual specificity protein phosphatase 7; MKP-; Mkpx; PYS; Pyst2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,245,831 - 106,252,923 (+)NCBIGRCm39mm39
GRCm389106,368,560 - 106,375,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,368,632 - 106,375,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,270,963 - 106,278,055 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,226,733 - 106,233,822 (+)NCBImm8
MGSCv369107,157,107 - 107,167,680 (+)NCBImm8
Celera9105,996,040 - 106,003,059 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:18058922   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22174793   PMID:27626380   PMID:27783954   PMID:30938680  


Genomics

Comparative Map Data
Dusp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,245,831 - 106,252,923 (+)NCBIGRCm39mm39
GRCm389106,368,560 - 106,375,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,368,632 - 106,375,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,270,963 - 106,278,055 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,226,733 - 106,233,822 (+)NCBImm8
MGSCv369107,157,107 - 107,167,680 (+)NCBImm8
Celera9105,996,040 - 106,003,059 (+)NCBICelera
Cytogenetic Map9F1NCBI
DUSP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,048,919 - 52,056,571 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,048,919 - 52,056,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,082,935 - 52,090,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,059,799 - 52,065,329 (-)NCBINCBI36hg18NCBI36
Build 34352,059,870 - 52,065,269NCBI
Celera352,062,259 - 52,069,785 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,146,055 - 52,153,134 (-)NCBIHuRef
CHM1_1352,035,473 - 52,042,994 (-)NCBICHM1_1
Dusp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08115,069,095 - 115,076,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,069,095 - 115,076,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,436,772 - 114,443,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,510,358 - 111,515,989 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18111,530,229 - 111,535,444 (+)NCBI
Celera8106,321,745 - 106,328,777 (+)NCBICelera
Cytogenetic Map8q32NCBI
Dusp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,685,137 - 3,691,933 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555323,685,137 - 3,691,933 (-)NCBIChiLan1.0ChiLan1.0
DUSP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1353,219,167 - 53,226,491 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,219,167 - 53,226,491 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0351,990,115 - 51,997,627 (-)NCBIMhudiblu_PPA_v0panPan3
DUSP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,676,077 - 37,682,003 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
DUSP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11334,199,404 - 34,210,621 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,396,095 - 37,404,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,416,262 - 13,423,736 (-)NCBI
ChlSab1.1 Ensembl2213,416,287 - 13,423,661 (-)Ensembl
Dusp7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247305,858,838 - 5,865,657 (-)NCBI

Position Markers
AU015694  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,375,440 - 106,375,642UniSTSGRCm38
MGSCv379106,277,771 - 106,277,973UniSTSGRCm37
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91100.22UniSTS
Dusp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,374,140 - 106,375,018UniSTSGRCm38
MGSCv379106,276,471 - 106,277,349UniSTSGRCm37
Celera9106,001,442 - 106,002,332UniSTS
Cytogenetic Map9F1UniSTS
cM Map9 UniSTS
RH133148  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,374,443 - 106,375,625UniSTSGRCm38
MGSCv379106,276,774 - 106,277,956UniSTSGRCm37
Celera9106,001,751 - 106,002,958UniSTS
Cytogenetic Map9F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1365
Count of miRNA genes:676
Interacting mature miRNAs:836
Transcripts:ENSMUST00000172306, ENSMUST00000173051, ENSMUST00000173748, ENSMUST00000174247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172306   ⟹   ENSMUSP00000126984
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,368,632 - 106,375,724 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173051
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,369,612 - 106,370,875 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173748   ⟹   ENSMUSP00000133511
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,370,744 - 106,373,856 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,374,619 - 106,375,721 (+)Ensembl
RefSeq Acc Id: NM_153459   ⟹   NP_703189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,245,831 - 106,252,923 (+)NCBI
GRCm389106,368,632 - 106,375,724 (+)NCBI
MGSCv379106,270,963 - 106,278,055 (+)RGD
Celera9105,996,040 - 106,003,059 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_703189   ⟸   NM_153459
- UniProtKB: Q91Z46 (UniProtKB/Swiss-Prot),   Q3TY83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126984   ⟸   ENSMUST00000172306
RefSeq Acc Id: ENSMUSP00000133511   ⟸   ENSMUST00000173748
Promoters
RGD ID:6844444
Promoter ID:MM_KWN:58663
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_153459
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,270,001 - 106,271,487 (+)MPROMDB
RGD ID:6848910
Promoter ID:MM_TRO:10277
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:MTR007988.9.2240.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,276,086 - 106,276,586 (+)MPROMDB
RGD ID:8670720
Promoter ID:EPDNEW_M13391
Type:initiation region
Name:Dusp7_1
Description:Mus musculus dual specificity phosphatase 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,368,632 - 106,368,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387100 AgrOrtholog
Ensembl Genes ENSMUSG00000053716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000126984 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133511 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000172306 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000173748 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235584 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2387100 ENTREZGENE
NCBI Gene 235584 ENTREZGENE
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Dusp7 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot
UniGene Mm.275584 ENTREZGENE
UniProt DUS7_MOUSE UniProtKB/Swiss-Prot
  G3UX16_MOUSE UniProtKB/TrEMBL
  Q3TY83 ENTREZGENE, UniProtKB/TrEMBL
  Q8R3L7_MOUSE UniProtKB/TrEMBL
  Q91Z46 ENTREZGENE
UniProt Secondary E9PVF4 UniProtKB/Swiss-Prot
  E9QMS8 UniProtKB/Swiss-Prot
  Q3USH2 UniProtKB/Swiss-Prot