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ONTOLOGY REPORT - ANNOTATIONS

Term:granulocyte differentiation
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Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation


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granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (PMID:23748140) RGD PMID:23748140 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935 		JBrowse link
G Bap1 Brca1 associated protein 1 involved_in ISO MGI:5439652 (PMID:22878500) RGD PMID:22878500 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535 		JBrowse link
G Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within ISO (PMID:15231665) RGD PMID:15231665 NCBI chr19:50,679,897...50,750,028
Ensembl chr19:50,680,729...50,749,610 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha involved_in ISS
ISO		 GO_REF:0000024
(MGI:2152476|PMID:11672531), (MGI:3513695|PMID:15589173)		 UniProt
RGD		 PMID:11672531 PMID:15589173 GO_REF:0000024 MGI:2152476 MGI:3513695 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon involved_in ISO (PMID:10359588) RGD PMID:10359588 NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:2385355 (PMID:17644732) RGD PMID:17644732 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Clpb ClpB family mitochondrial disaggregase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:34115842), (PMID:34140661)		 UniProt
Ensembl
RGD		 PMID:34115842 PMID:34140661 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:18401763 RGD:4784626 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP RGD PMID:18401763 RGD:4784626 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 acts_upstream_of_or_within ISO MGI:3579468 (PMID:15889154) RGD PMID:15889154 NCBI chr 1:18,988,763...19,089,247
Ensembl chr 1:18,990,618...19,089,263 		JBrowse link
G Mir223 microRNA 223 acts_upstream_of ISO MGI:3811186 (PMID:18278031) RGD PMID:18278031 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Nkap NFKB activating protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2176073|MGI:4839023 (PMID:20610818)		 Ensembl
RGD		 PMID:20610818 GO_REF:0000107 NCBI chr  X:116,373,031...116,392,677
Ensembl chr  X:116,372,839...116,394,945 		JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO MGI:2182438 (PMID:12676787) RGD PMID:12676787 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (PMID:11980719) RGD PMID:11980719 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Srp54a signal recognition particle 54A involved_in ISS
ISO		 GO_REF:0000024
(PMID:28972538)		 UniProt
RGD		 PMID:28972538 GO_REF:0000024 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
G Zfpm1 zinc finger protein, multitype 1 acts_upstream_of_or_within ISO MGI:2176182|MGI:4421436 (PMID:20010697) RGD PMID:20010697 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591 		JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:7678994) RGD PMID:7678994 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in ISO (PMID:7678994) RGD PMID:7678994 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976 		JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:8507862) RGD PMID:8507862 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Il25 interleukin 25 acts_upstream_of_or_within ISO (PMID:12077275) RGD PMID:12077275 NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:11823534) RGD PMID:11823534 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in IEA
ISO		 GO_REF:0000107
(PMID:12393707)		 Ensembl
RGD		 PMID:12393707 GO_REF:0000107 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:12045236) RGD PMID:12045236 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gata2 GATA binding protein 2 involved_in ISO (PMID:12045236) RGD PMID:12045236 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS		 (PMID:10961870)
GO_REF:0000024		 RGD
UniProt		 PMID:10961870 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:10961870)
GO_REF:0000107		 RGD
Ensembl		 PMID:10961870 GO_REF:0000107 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4837548|PMID:21029969)		 UniProt
RGD		 PMID:21029969 GO_REF:0000024 MGI:4837548 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO (PMID:12393421) RGD PMID:12393421 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (PMID:9620849) RGD PMID:9620849 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Prdm16 PR/SET domain 16 involved_in ISO (PMID:12816872) RGD PMID:12816872 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:19917671) RGD PMID:19917671 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) RGD PMID:9199349 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
MGI:2386884 (PMID:9620849)		 Ensembl
GO_Central
RGD		 PMID:9620849 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bap1 Brca1 associated protein 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:5439652 (PMID:22878500)		 Ensembl
RGD		 PMID:22878500 GO_REF:0000107 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535 		JBrowse link
G Csf2 colony stimulating factor 2 acts_upstream_of_or_within ISO (PMID:19109256) RGD PMID:19109256 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Dhrs7b dehydrogenase/reductase 7B involved_in IEA
ISO		 GO_REF:0000107
MGI:5749209 (PMID:25565205)		 Ensembl
RGD		 PMID:25565205 GO_REF:0000107 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076 		JBrowse link
G Fasn fatty acid synthase involved_in IEA
ISO		 GO_REF:0000107
MGI:3765070 (PMID:25565205)		 Ensembl
RGD		 PMID:25565205 GO_REF:0000107 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:30181393)		 Ensembl
RGD		 PMID:30181393 GO_REF:0000107 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Il17c interleukin 17C acts_upstream_of_or_within ISO (PMID:12077275) RGD PMID:12077275 NCBI chr19:50,484,890...50,486,169
Ensembl chr19:50,484,890...50,486,169 		JBrowse link
G Jagn1 jagunal homolog 1 involved_in
NOT|involved_in		 ISO
ISS		 (PMID:25129144)
(MGI:5604054|PMID:25129145)
GO_REF:0000024		 RGD
UniProt		 PMID:25129144 PMID:25129145 GO_REF:0000024 MGI:5604054 NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288 		JBrowse link
G Lbr lamin B receptor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5308142|PMID:22140257)		 UniProt
Ensembl
RGD		 PMID:22140257 GO_REF:0000024 GO_REF:0000107 MGI:5308142 NCBI chr13:93,539,386...93,564,026
Ensembl chr13:93,538,920...93,564,017 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO
IEA		 (PMID:17063141)
GO_REF:0000107		 RGD
Ensembl		 PMID:17063141 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il5 interleukin 5 IDA RGD PMID:10727846 PMID:10529595 RGD:2303509, RGD:2303750 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evi2b ecotropic viral integration site 2B involved_in ISO (PMID:28186500) RGD PMID:28186500 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560 		JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942 		JBrowse link
G Hax1 HCLS1 associated protein X-1 involved_in ISO (PMID:23001182) RGD PMID:23001182 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 involved_in ISO (PMID:23001182)
(MGI:5448611|PMID:23001182)		 RGD PMID:23001182 MGI:5448611 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO
IEA		 (PMID:19620402), (PMID:23001182)
GO_REF:0000107		 RGD
Ensembl		 PMID:19620402 PMID:23001182 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Mir223 microRNA 223 acts_upstream_of_or_within ISO MGI:3811186 (PMID:18278031) RGD PMID:18278031 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir486 microRNA 486 involved_in ISO (PMID:25857263) RGD PMID:25857263
G Runx1 RUNX family transcription factor 1 involved_in ISO
ISS
IEA		 (PMID:9199349)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:9199349 GO_REF:0000024 GO_REF:0000107 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Tesc tescalcin involved_in ISO
IBA		 (PMID:20060826)
GO_REF:0000033		 RGD
GO_Central		 PMID:20060826 GO_REF:0000033 NCBI chr12:38,521,832...38,555,665
Ensembl chr12:38,521,861...38,555,824 		JBrowse link
G Tescl tescalcin-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:79,896,554...79,920,998
Ensembl chr 1:79,920,075...79,920,985 		JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evi2b ecotropic viral integration site 2B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2667175 (PMID:12406904) RGD PMID:12406904 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO MGI:1857622 (PMID:11222375) RGD PMID:11222375 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rbp1 retinol binding protein 1 acts_upstream_of_or_within ISO MGI:2181412 (PMID:11222375) RGD PMID:11222375 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    developmental process 6963
      cellular developmental process 4695
        cell differentiation 4694
          leukocyte differentiation 674
            myeloid leukocyte differentiation 280
              granulocyte differentiation 51
                basophil differentiation + 2
                eosinophil differentiation + 7
                negative regulation of granulocyte differentiation + 10
                neutrophil differentiation + 13
                positive regulation of granulocyte differentiation + 13
                regulation of granulocyte differentiation + 22
Path 2
Term Annotations click to browse term
  biological_process 19694
    developmental process 6963
      cellular developmental process 4695
        cell differentiation 4694
          cell development 3269
            hemopoiesis 1061
              myeloid cell differentiation 506
                myeloid leukocyte differentiation 280
                  granulocyte differentiation 51
                    basophil differentiation + 2
                    eosinophil differentiation + 7
                    negative regulation of granulocyte differentiation + 10
                    neutrophil differentiation + 13
                    positive regulation of granulocyte differentiation + 13
                    regulation of granulocyte differentiation + 22
paths to the root