Il25 (interleukin 25) - Rat Genome Database

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Gene: Il25 (interleukin 25) Rattus norvegicus
Symbol: Il25
Name: interleukin 25
RGD ID: 1561632
Description: Predicted to enable cytokine activity. Involved in inflammatory response to antigenic stimulus. Located in extracellular space. Biomarker of gastric ulcer. Orthologous to human IL25 (interleukin 25); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH bisphenol A; Cuprizon; erlotinib hydrochloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interleukin-25; LOC501996; RGD1561632; similar to IL25
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21528,408,766 - 28,412,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,408,842 - 28,411,893 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,254,511 - 30,257,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,401,713 - 31,404,548 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,644,433 - 29,647,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,594,852 - 33,599,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,596,301 - 33,599,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,483,323 - 37,486,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,035,230 - 33,038,064 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,986,647 - 27,989,481 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. Ballantyne SJ, etal., J Allergy Clin Immunol. 2007 Dec;120(6):1324-31. doi: 10.1016/j.jaci.2007.07.051. Epub 2007 Sep 24.
2. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Beale J, etal., Sci Transl Med. 2014 Oct 1;6(256):256ra134. doi: 10.1126/scitranslmed.3009124.
3. [Effects of acupuncture stimulation of different acupoint groups on sleeping latency, serum and hippocampal TNF-α and IL-25 contents in rats with gastric mucosal injury]. Huang YH, etal., Zhen Ci Yan Jiu. 2015 Apr;40(2):131-5.
4. Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles. Kang CM, etal., Am J Respir Cell Mol Biol. 2005 Sep;33(3):290-6. Epub 2005 Jun 16.
5. IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication. Kim BE, etal., J Invest Dermatol. 2013 Dec;133(12):2678-2685. doi: 10.1038/jid.2013.223. Epub 2013 May 8.
6. Inhibitory effect of recombinant IL-25 on the development of dextran sulfate sodium-induced experimental colitis in mice. Mchenga SS, etal., Cell Mol Immunol. 2008 Dec;5(6):425-31. doi: 10.1038/cmi.2008.53.
7. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. Mishra NC, etal., J Immunol. 2008 Jun 1;180(11):7655-63.
8. Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis. Noor Z, etal., mBio. 2017 Feb 28;8(1). pii: mBio.02329-16. doi: 10.1128/mBio.02329-16.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11714825   PMID:12077275   PMID:18768888   PMID:21460847  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21528,408,766 - 28,412,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,408,842 - 28,411,893 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,254,511 - 30,257,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,401,713 - 31,404,548 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,644,433 - 29,647,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,594,852 - 33,599,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,596,301 - 33,599,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,483,323 - 37,486,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,035,230 - 33,038,064 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,986,647 - 27,989,481 (+)NCBICelera
Cytogenetic Map15p13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381423,372,809 - 23,376,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,372,809 - 23,376,403 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,842,018 - 23,845,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,911,858 - 22,915,452 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,911,857 - 22,915,452NCBI
Celera143,704,729 - 3,708,323 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,958,437 - 3,962,031 (+)NCBIHuRef
CHM1_11423,840,690 - 23,844,284 (+)NCBICHM1_1
T2T-CHM13v2.01417,573,825 - 17,577,419 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391455,170,152 - 55,173,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,170,152 - 55,173,294 (+)EnsemblGRCm39 Ensembl
GRCm381454,932,695 - 54,935,837 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,932,695 - 54,935,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,551,532 - 55,554,674 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,886,980 - 53,890,043 (+)NCBIMGSCv36mm8
Celera1452,738,886 - 52,742,027 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.0NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540936,961,398 - 36,964,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,960,902 - 36,964,038 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11424,020,977 - 24,024,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,191,888 - 4,195,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,286,347 - 22,289,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,286,347 - 22,289,498 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.183,621,268 - 3,624,689 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,618,161 - 3,624,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,569,370 - 3,572,805 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,728,890 - 3,732,325 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,725,891 - 3,747,853 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,420,449 - 3,423,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,481,722 - 3,485,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,743,917 - 3,747,352 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864035,384,643 - 35,391,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722996,960 - 1,003,201 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936722997,476 - 1,000,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl775,709,995 - 75,714,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,710,453 - 75,717,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,020,938 - 81,030,418 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12923,742,377 - 23,747,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,744,449 - 23,747,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,671,106 - 22,680,822 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248209,188,612 - 9,191,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,188,709 - 9,192,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il25
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:46
Interacting mature miRNAs:50
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,411,959 - 28,412,134 (+)MAPPERmRatBN7.2
Rnor_6.01533,599,495 - 33,599,669NCBIRnor6.0
Rnor_5.01537,486,441 - 37,486,615UniSTSRnor5.0
RGSC_v3.41533,038,348 - 33,038,522UniSTSRGSC3.4
Celera1527,989,765 - 27,989,939UniSTS
Cytogenetic Map15p13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 2 2 38 2 15 3
Below cutoff 3 24 5 4 1 4 2 2 36 16 16 6 2


RefSeq Acc Id: ENSRNOT00000022563   ⟹   ENSRNOP00000022563
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,408,842 - 28,411,893 (+)Ensembl
Rnor_6.0 Ensembl1533,596,301 - 33,599,685 (+)Ensembl
RefSeq Acc Id: NM_001192007   ⟹   NP_001178936
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,408,766 - 28,412,157 (+)NCBI
Rnor_6.01533,596,377 - 33,599,211 (+)NCBI
Rnor_5.01537,483,323 - 37,486,157 (+)NCBI
Celera1527,986,647 - 27,989,481 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178936 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14205 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178936   ⟸   NM_001192007
- UniProtKB: D3ZLB1 (UniProtKB/TrEMBL),   A6KGX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022563   ⟸   ENSRNOT00000022563

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLB1-F1-model_v2 AlphaFold D3ZLB1 1-169 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561632 AgrOrtholog
BioCyc Gene G2FUF-13765 BioCyc
Ensembl Genes ENSRNOG00000016804 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022563 ENTREZGENE
  ENSRNOP00000022563.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022563 ENTREZGENE
  ENSRNOT00000022563.5 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Interleukin-17_met UniProtKB/TrEMBL
KEGG Report rno:501996 UniProtKB/TrEMBL
Pfam IL17 UniProtKB/TrEMBL
PhenoGen Il25 PhenoGen
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Il25  interleukin 25  RGD1561632_predicted  similar to IL25 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561632_predicted  similar to IL25 (predicted)  LOC501996  similar to IL25  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501996  similar to IL25      Symbol and Name status set to provisional 70820 PROVISIONAL