Zfpm1 (zinc finger protein, multitype 1) - Rat Genome Database

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Pathways
Gene: Zfpm1 (zinc finger protein, multitype 1) Rattus norvegicus
Analyze
Symbol: Zfpm1
Name: zinc finger protein, multitype 1
RGD ID: 1582810
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in several processes, including heart development; hemopoiesis; and regulation of gene expression. Predicted to act upstream of or within myeloid cell differentiation and regulation of chemokine production. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100365064; LOC365021; similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1); zinc finger protein ZFPM1; zinc finger protein, multitype 1-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Leukc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21950,334,352 - 50,391,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,334,682 - 50,390,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,127,757 - 57,183,242 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,809,629 - 57,865,538 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,026,369 - 60,081,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,094,585 - 55,150,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,094,585 - 55,150,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,834,230 - 65,865,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,526,720 - 52,587,089 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,556,024 - 52,591,908 (+)NCBI
Celera1949,574,993 - 49,630,920 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2906112   PMID:9230307   PMID:9553047   PMID:11675338   PMID:12213678   PMID:12483298   PMID:12923059   PMID:14614148   PMID:15644435   PMID:15920471   PMID:17207461   PMID:18063754  
PMID:19654328   PMID:20010697   PMID:20643340   PMID:20705609   PMID:21245044   PMID:21646796  


Genomics

Comparative Map Data
Zfpm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21950,334,352 - 50,391,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,334,682 - 50,390,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,127,757 - 57,183,242 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,809,629 - 57,865,538 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,026,369 - 60,081,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,094,585 - 55,150,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,094,585 - 55,150,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,834,230 - 65,865,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,526,720 - 52,587,089 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,556,024 - 52,591,908 (+)NCBI
Celera1949,574,993 - 49,630,920 (+)NCBICelera
Cytogenetic Map19q12NCBI
ZFPM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,451,769 - 88,537,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,453,280 - 88,537,031 (+)EnsemblGRCh38hg38GRCh38
GRCh371688,519,688 - 88,603,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,047,515 - 87,129,075 (+)NCBINCBI36Build 36hg18NCBI36
Build 341687,047,225 - 87,128,890NCBI
Celera1673,590,446 - 73,671,847 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,246,210 - 74,295,079 (+)NCBIHuRef
CHM1_11689,931,284 - 90,012,844 (+)NCBICHM1_1
T2T-CHM13v2.01694,519,763 - 94,605,071 (+)NCBIT2T-CHM13v2.0
Zfpm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,008,595 - 123,064,601 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,008,880 - 123,063,990 (+)EnsemblGRCm39 Ensembl
GRCm388122,281,856 - 122,337,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,282,141 - 122,337,251 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,806,041 - 124,861,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,168,229 - 125,223,337 (+)NCBIMGSCv36mm8
Celera8126,511,563 - 126,566,323 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.86NCBI
Zfpm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555412,461,690 - 2,495,614 (+)NCBIChiLan1.0ChiLan1.0
ZFPM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan116104,136,147 - 104,218,190 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,164,299 - 69,246,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11688,822,837 - 88,907,872 (+)NCBIpanpan1.1PanPan1.1panPan2
ZFPM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,812,353 - 64,863,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,820,829 - 64,864,703 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0565,029,857 - 65,099,228 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl565,029,803 - 65,098,812 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1565,055,509 - 65,124,115 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,887,350 - 64,955,887 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,293,764 - 65,363,124 (-)NCBIUU_Cfam_GSD_1.0
Zfpm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,376,523 - 25,416,373 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,130,446 - 1,138,473 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366411,130,073 - 1,162,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFPM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,091,259 - 1,107,096 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,091,158 - 1,153,972 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZFPM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1573,832,527 - 73,909,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl573,864,461 - 73,909,049 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660471,776,729 - 1,854,713 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfpm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746988,512 - 1,017,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746988,114 - 1,035,697 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfpm1
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:72
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000068452
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 30 33 33 7 33 1 31 20 31 3
Low 2 13 24 8 12 8 8 10 43 15 10 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000068452   ⟹   ENSRNOP00000061082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,334,682 - 50,390,591 (+)Ensembl
Rnor_6.0 Ensembl1955,094,585 - 55,150,686 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111720   ⟹   ENSRNOP00000081045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,358,200 - 50,390,529 (+)Ensembl
RefSeq Acc Id: NM_001242627   ⟹   NP_001229556
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,334,682 - 50,390,591 (+)NCBI
Rnor_6.01955,094,585 - 55,150,686 (+)NCBI
Rnor_5.01965,834,230 - 65,865,945 (+)NCBI
Celera1949,574,993 - 49,630,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772649   ⟹   XP_008770871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,377,797 - 50,391,029 (+)NCBI
Rnor_6.01955,137,602 - 55,150,994 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098006   ⟹   XP_038953934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,334,352 - 50,391,029 (+)NCBI
RefSeq Acc Id: XM_039098007   ⟹   XP_038953935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,334,629 - 50,390,602 (+)NCBI
RefSeq Acc Id: XM_039098008   ⟹   XP_038953936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21950,388,458 - 50,391,029 (+)NCBI
RefSeq Acc Id: NP_001229556   ⟸   NM_001242627
- UniProtKB: A6IZR2 (UniProtKB/TrEMBL),   A0A8I5ZR33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770871   ⟸   XM_008772649
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZR33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061082   ⟸   ENSRNOT00000068452
RefSeq Acc Id: XP_038953934   ⟸   XM_039098006
- Peptide Label: isoform X1
- UniProtKB: D4A168 (UniProtKB/TrEMBL),   A0A8I5ZR33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953935   ⟸   XM_039098007
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZR33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953936   ⟸   XM_039098008
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000081045   ⟸   ENSRNOT00000111720
Protein Domains
C2H2-type   CCHC FOG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A168-F1-model_v2 AlphaFold D4A168 1-997 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582810 AgrOrtholog
BioCyc Gene G2FUF-5406 BioCyc
Ensembl Genes ENSRNOG00000043077 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000061082 ENTREZGENE
  ENSRNOP00000061082.4 UniProtKB/TrEMBL
  ENSRNOP00000081045 ENTREZGENE
  ENSRNOP00000081045.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068452 ENTREZGENE
  ENSRNOT00000068452.4 UniProtKB/TrEMBL
  ENSRNOT00000111720 ENTREZGENE
  ENSRNOT00000111720.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro FOG UniProtKB/TrEMBL
  ZF_CCHC_FOG UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 691504 ENTREZGENE
PANTHER PTHR12958 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN ZFPM1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-met UniProtKB/TrEMBL
PhenoGen Zfpm1 PhenoGen
PROSITE ZF_CCHC_FOG UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZR33 ENTREZGENE, UniProtKB/TrEMBL
  A6IZR2 ENTREZGENE, UniProtKB/TrEMBL
  D4A168 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-16 Zfpm1-ps1  zinc finger protein, multitype 1, pseudogene 1  LOC100365064  zinc finger protein, multitype 1-like  Data Merged 737654 APPROVED
2011-06-16 Zfpm1  zinc finger protein, multitype 1  Zfpm1-ps1  zinc finger protein, multitype 1, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-15 LOC691504  similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1)  Zfpm1  zinc finger protein, multitype 1  Data Merged 737654 APPROVED
2010-05-05 LOC100365064  zinc finger protein, multitype 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zfpm1  zinc finger protein, multitype 1   Zfpm1_predicted  zinc finger protein, multitype 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC691504  similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1)  LOC687202  similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1)  Data Merged 1643240 APPROVED
2006-11-19 LOC691504  similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687202  similar to Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Zfpm1_predicted  zinc finger protein, multitype 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED