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ONTOLOGY REPORT - ANNOTATIONS

Term:forebrain neuron differentiation
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Accession:GO:0021879 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.


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forebrain neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 IDA RGD PMID:17936272 RGD:2314144 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IEA
ISO		 GO_REF:0000107
(MGI:5430247|PMID:22542597)		 Ensembl
RGD		 PMID:22542597 GO_REF:0000107 MGI:5430247 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Dlx1 distal-less homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:94902 (PMID:11163262)		 Ensembl
RGD		 PMID:11163262 GO_REF:0000107 NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780 		JBrowse link
G Dlx2 distal-less homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:94901 (PMID:11163262)		 Ensembl
RGD		 PMID:11163262 GO_REF:0000107 NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597 		JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO MGI:2152620 (PMID:10325223) RGD PMID:10325223 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625 		JBrowse link
G Lhx8 LIM homeobox 8 acts_upstream_of_or_within ISO MGI:3603531 (PMID:15978004) RGD PMID:15978004 NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416 		JBrowse link
G Nkx2-1 NK2 homeobox 1 acts_upstream_of_or_within ISO MGI:1857494 (PMID:11163262) RGD PMID:11163262 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Otp orthopedia homeobox acts_upstream_of_or_within ISO MGI:2180541 (PMID:17481897) RGD PMID:17481897 NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 IEP RGD PMID:10428057 RGD:70034 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Pou3f4 POU class 3 homeobox 4 acts_upstream_of_or_within ISO (PMID:9889200) RGD PMID:9889200 NCBI chr  X:75,858,646...75,859,923
Ensembl chr  X:75,858,646...75,859,923 		JBrowse link
G Sox1 SRY-box transcription factor 1 acts_upstream_of_or_within ISO MGI:2137412 (PMID:15882093) RGD PMID:15882093 NCBI chr16:77,135,577...77,139,592
Ensembl chr16:77,137,584...77,138,762 		JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO MGI:2181440|MGI:3052123 (PMID:15240551) RGD PMID:15240551 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
commitment of neuronal cell to specific neuron type in forebrain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857470 (PMID:22991444) RGD PMID:22991444 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2679336 (PMID:23144223) RGD PMID:23144223 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Fezf2 Fez family zinc finger 2 acts_upstream_of_or_within ISO MGI:3046867 (PMID:21338885) RGD PMID:21338885 NCBI chr15:12,768,614...12,777,554
Ensembl chr15:12,773,762...12,777,554 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO MGI:4818492 (PMID:22991444) RGD PMID:22991444 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Pax6 paired box 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1856158 (PMID:11124115)		 Ensembl
RGD		 PMID:11124115 GO_REF:0000107 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Tbr1 T-box brain transcription factor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2679336 (PMID:23144223)		 GO_Central
RGD		 PMID:23144223 GO_REF:0000033 NCBI chr 3:46,350,237...46,368,397
Ensembl chr 3:46,351,213...46,361,041 		JBrowse link
forebrain neuron development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf8 fibroblast growth factor 8 IMP induction of dopaminergic neurons in the rostral forebrain RGD PMID:9630220 RGD:2289424 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO MGI:1857634 (PMID:21048141) RGD PMID:21048141 NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212 		JBrowse link
G Gnaq G protein subunit alpha q involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2151661 (PMID:15340067)		 Ensembl
RGD		 PMID:15340067 GO_REF:0000107 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Lhx6 LIM homeobox 6 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1096343 (PMID:15217369)		 GO_Central
RGD		 PMID:15217369 GO_REF:0000033 NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061 		JBrowse link
G Lhx8 LIM homeobox 8 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1306803 (PMID:15217369)		 GO_Central
RGD		 PMID:15217369 GO_REF:0000033 NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3848551|PMID:19453629)		 UniProt
RGD		 PMID:19453629 GO_REF:0000024 MGI:3848551 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Secisbp2 SECIS binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2181426|MGI:5583885 (PMID:24844465)		 Ensembl
RGD		 PMID:24844465 GO_REF:0000107 NCBI chr17:13,538,513...13,569,573
Ensembl chr17:13,538,513...13,569,523 		JBrowse link
G Sox1 SRY-box transcription factor 1 acts_upstream_of_or_within ISO MGI:2137412 (PMID:15882093) RGD PMID:15882093 NCBI chr16:77,135,577...77,139,592
Ensembl chr16:77,137,584...77,138,762 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:1888387 (PMID:10803593) RGD PMID:10803593 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
forebrain neuron fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lhx6 LIM homeobox 6 acts_upstream_of_or_within ISO MGI:108067 (PMID:18339674) RGD PMID:18339674 NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1306803|MGI:1857494 (PMID:18339674)		 Ensembl
RGD		 PMID:18339674 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Tfap2c transcription factor AP-2 gamma acts_upstream_of_or_within ISO MGI:2176695 (PMID:19749747) RGD PMID:19749747 NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995 		JBrowse link
gonadotrophin-releasing hormone neuronal migration to the hypothalamus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndnf neuron-derived neurotrophic factor involved_in ISO (MGI:6442643|PMID:31883645) RGD PMID:31883645 MGI:6442643 NCBI chr 4:94,944,392...94,981,871
Ensembl chr 4:94,944,360...94,981,873 		JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (MGI:4850173|PMID:21059704) RGD PMID:21059704 MGI:4850173 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 involved_in ISO
IEA		 (MGI:4850173|PMID:21059704)
GO_REF:0000107		 RGD
Ensembl		 PMID:21059704 GO_REF:0000107 MGI:4850173 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Plxna1 plexin A1 involved_in ISO UniProtKB:P70208 (MGI:6389759|PMID:31690636) RGD PMID:31690636 MGI:6389759 NCBI chr 4:121,737,934...121,782,901
Ensembl chr 4:121,737,945...122,024,196 		JBrowse link
G Plxna3 plexin A3 involved_in ISO UniProtKB:P70206 (MGI:6389759|PMID:31690636) RGD PMID:31690636 MGI:6389759 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Sema3a semaphorin 3A involved_in ISO (MGI:4850173|PMID:21059704) RGD PMID:21059704 MGI:4850173 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Sema3e semaphorin 3E involved_in ISO (PMID:25985275) RGD PMID:25985275 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
hypothalamus gonadotrophin-releasing hormone neuron development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nhlh2 nescient helix loop helix 2 acts_upstream_of_or_within_positive_effect ISO (MGI:5504302|PMID:23785158) RGD PMID:23785158 MGI:5504302 NCBI chr 2:189,444,287...189,449,625
Ensembl chr 2:189,442,711...189,449,625 		JBrowse link
G Ubb ubiquitin B acts_upstream_of_or_within ISO MGI:3774112 (PMID:18299572) RGD PMID:18299572 NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
negative regulation of forebrain neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin involved_in ISO
IEA		 (PMID:26147761)
(MGI:5708430|PMID:26147761)
GO_REF:0000107		 RGD
Ensembl		 PMID:26147761 GO_REF:0000107 MGI:5708430 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in IDA PMID:11399758 UniProt PMID:11399758 RGD:8554692 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 involved_in IDA PMID:11399758 UniProt PMID:11399758 RGD:8554692 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:19555672 RGD:10043320 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
positive regulation of forebrain neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prox1 prospero homeobox 1 involved_in ISO (MGI:4849596|PMID:20808958) RGD PMID:20808958 MGI:4849596 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
pyramidal neuron development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2386545|MGI:3587769 (PMID:16625205) RGD PMID:16625205 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (PMID:2473662) RGD PMID:2473662 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Dclk2 doublecortin-like kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1277171 (PMID:19342486)		 Ensembl
RGD		 PMID:19342486 GO_REF:0000107 NCBI chr 2:172,202,733...172,338,411
Ensembl chr 2:172,208,706...172,338,250 		JBrowse link
G Dcx doublecortin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1918012 (PMID:19342486)		 Ensembl
RGD		 PMID:19342486 GO_REF:0000107 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 involved_in ISO (MGI:4452541|PMID:20410112) RGD PMID:20410112 MGI:4452541 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Ogdh oxoglutarate dehydrogenase involved_in ISO
IEA		 (MGI:3662936|PMID:16901643)
GO_REF:0000107		 RGD
Ensembl		 PMID:16901643 GO_REF:0000107 MGI:3662936 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Plxna3 plexin A3 acts_upstream_of_or_within ISO MGI:2386961 (PMID:11683995) RGD PMID:11683995 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Scyl2 SCY1 like pseudokinase 2 involved_in ISO (MGI:5694521|PMID:26203146) RGD PMID:26203146 MGI:5694521 NCBI chr 7:24,064,404...24,117,338
Ensembl chr 7:24,064,404...24,117,305 		JBrowse link
G Slc4a10 solute carrier family 4 member 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3774019 (PMID:18165320)		 Ensembl
RGD		 PMID:18165320 GO_REF:0000107 NCBI chr 3:46,665,076...46,959,088
Ensembl chr 3:46,665,265...46,957,268 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII involved_in ISO (MGI:3662936|PMID:16901643) RGD PMID:16901643 MGI:3662936 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
pyramidal neuron migration to cerebral cortex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disc1 DISC1 scaffold protein IMP RGD PMID:16299498 RGD:5509783 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Foxg1 forkhead box G1 acts_upstream_of_or_within ISO (PMID:22726835) RGD PMID:22726835 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607 		JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 involved_in ISO (PMID:30639322) RGD PMID:30639322 NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597 		JBrowse link
regulation of forebrain neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO MGI:4818492 (PMID:22991444) RGD PMID:22991444 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
striatal medium spiny neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2663971 (PMID:18199763) RGD PMID:18199763 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:25804741) RGD PMID:25804741 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:4948759|PMID:21423165)
GO_REF:0000024		 Ensembl
RGD
BHF-UCL		 PMID:21423165 GO_REF:0000024 GO_REF:0000107 MGI:4948759 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 involved_in ISO (MGI:6140923|PMID:28433741) RGD PMID:28433741 MGI:6140923 NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure development 6486
        forebrain development 555
          forebrain generation of neurons 66
            forebrain neuron differentiation 54
              early neuron differentiation in forebrain + 0
              forebrain neuron development + 30
              forebrain neuron fate commitment + 9
              negative regulation of forebrain neuron differentiation 4
              positive regulation of forebrain neuron differentiation 1
              regulation of forebrain neuron differentiation + 6
              striatal medium spiny neuron differentiation 4
Path 2
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure development 6486
        multicellular organism development 5239
          system development 4526
            nervous system development 2801
              central nervous system development 1203
                brain development 900
                  forebrain development 555
                    forebrain generation of neurons 66
                      forebrain neuron differentiation 54
                        early neuron differentiation in forebrain + 0
                        forebrain neuron development + 30
                        forebrain neuron fate commitment + 9
                        negative regulation of forebrain neuron differentiation 4
                        positive regulation of forebrain neuron differentiation 1
                        regulation of forebrain neuron differentiation + 6
                        striatal medium spiny neuron differentiation 4
paths to the root