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ONTOLOGY REPORT - ANNOTATIONS

Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


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ER-nucleus signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:14561754)		 Ensembl
RGD		 PMID:14561754 GO_REF:0000107 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO (PMID:17256008) RGD PMID:17256008 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within ISO (PMID:17204322) RGD PMID:17204322 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA		 MGI:2179046 (PMID:11854325)
GO_REF:0000033		 RGD
GO_Central		 PMID:11854325 PMID:11158311 GO_REF:0000033, RGD:70575 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
ISS		 (PMID:10677345), (PMID:11907036)
GO_REF:0000024		 RGD
UniProt		 PMID:10677345 PMID:11907036 GO_REF:0000024 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11854325)		 Ensembl
RGD		 PMID:11854325 GO_REF:0000107 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ins2 insulin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857572 (PMID:11854325)		 Ensembl
RGD		 PMID:11854325 GO_REF:0000107 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B acts_upstream_of_or_within ISO (PMID:14638860) RGD PMID:14638860 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA		 (PMID:16574427), (PMID:17210132)
GO_REF:0000107		 RGD
Ensembl		 PMID:16574427 PMID:17210132 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISO
IEA
ISS		 (PMID:27212239)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27212239 GO_REF:0000024 GO_REF:0000107 NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO		 PMID:20160352
(PMID:20160352)		 RGD PMID:20160352 PMID:20160352 RGD:10047363 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
GO_REF:0000033
UniProtKB:O55033 (MGI:5613478|PMID:14676213)		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
GO_REF:0000033		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA		 (PMID:21216966)
(MGI:5619464|PMID:21216966)
GO_REF:0000033		 RGD
GO_Central		 PMID:21216966 GO_REF:0000033 MGI:5619464 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)		 UniProt
RGD		 PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS		 (PMID:33384352)
GO_REF:0000024		 RGD
UniProt		 PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rpap2 RNA polymerase II associated protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30118681)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30118681 GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO
IEA		 (PMID:9837962)
GO_REF:0000107		 RGD
Ensembl		 PMID:9837962 GO_REF:0000107 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:25772147 RGD:13782257 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5648772|PMID:26015568)		 UniProt
RGD		 PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA		 (MGI:5619464|PMID:21216966)
GO_REF:0000107		 RGD
Ensembl		 PMID:21216966 GO_REF:0000107 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS		 (PMID:26268696)
GO_REF:0000024		 RGD
UniProt		 PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir96 microRNA 96 involved_in ISO (PMID:30460077) RGD PMID:30460077 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)		 RGD PMID:32111832 MGI:6401656 NCBI chr12:38,306,227...38,329,175
Ensembl chr12:38,297,837...38,329,138 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:6120228 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) RGD PMID:22863805 MGI:6276494 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IBA		 (PMID:16112081)
GO_REF:0000033		 RGD
GO_Central		 PMID:16112081 GO_REF:0000033 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12242332), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12242332 PMID:32322062 GO_REF:0000033 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:12242332), (PMID:17428920), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:12242332 PMID:17428920 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
G Scap SREBF chaperone involved_in ISO
ISS		 (PMID:11726962), (PMID:32322062)
GO_REF:0000024		 RGD
UniProt		 PMID:11726962 PMID:32322062 GO_REF:0000024 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
ISS		 (PMID:27614840)
GO_REF:0000024
(PMID:32322062)		 RGD
UniProt		 PMID:27614840 PMID:32322062 GO_REF:0000024 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:32322062)
(PMID:27614840)		 Ensembl
UniProt
RGD		 PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12202038), (PMID:15899885), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12202038 PMID:15899885 PMID:32322062 GO_REF:0000033 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:15899885), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:15899885 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    cellular process 18525
      signal transduction 7080
        intracellular signal transduction 3048
          ER-nucleus signaling pathway 46
            ATF6-mediated unfolded protein response + 3
            ER overload response + 13
            PERK-mediated unfolded protein response + 16
            SREBP signaling pathway + 16
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13552
      regulation of biological process 13126
        signaling 7639
          signal transduction 7080
            intracellular signal transduction 3048
              ER-nucleus signaling pathway 46
                ATF6-mediated unfolded protein response + 3
                ER overload response + 13
                PERK-mediated unfolded protein response + 16
                SREBP signaling pathway + 16
paths to the root