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ONTOLOGY REPORT - ANNOTATIONS

Term:ER overload response
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Accession:GO:0006983 term browser browse the term
Definition:The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Synonyms:exact_synonym: EOR;   endoplasmic reticulum overload response
 narrow_synonym: EOR-mediated NF-kappaB activation;   EOR-mediated activation of NF-kappaB;   positive regulation of NF-kappaB transcription factor activity by EOR;   positive regulation of NF-kappaB transcription factor activity by ER overload response
 alt_id: GO:0006985


show annotations for term's descendants           Sort by:
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO (PMID:17256008) RGD PMID:17256008 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within ISO
IEA		 (PMID:17204322)
GO_REF:0000107		 RGD
Ensembl		 PMID:17204322 GO_REF:0000107 NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 IMP
IEA
ISO
IBA		 GO_REF:0000107
MGI:2179046 (PMID:11854325)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:11854325 PMID:11158311 GO_REF:0000033 GO_REF:0000107, RGD:70575 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
IEA
ISS		 (PMID:10677345), (PMID:11907036)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:10677345 PMID:11907036 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 acts_upstream_of_or_within ISO
IEA		 (PMID:11854325)
GO_REF:0000107		 RGD
Ensembl		 PMID:11854325 GO_REF:0000107 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ins2 insulin 2 acts_upstream_of_or_within ISO
IEA		 MGI:1857572 (PMID:11854325)
GO_REF:0000107		 RGD
Ensembl		 PMID:11854325 GO_REF:0000107 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B acts_upstream_of_or_within ISO
IEA		 (PMID:14638860)
GO_REF:0000107		 RGD
Ensembl		 PMID:14638860 GO_REF:0000107 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA		 (PMID:16574427), (PMID:17210132)
GO_REF:0000107		 RGD
Ensembl		 PMID:16574427 PMID:17210132 GO_REF:0000107 NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISO
IEA
ISS		 (PMID:27212239)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27212239 GO_REF:0000024 GO_REF:0000107 NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IEA
ISO		 GO_REF:0000107
(PMID:16989814)		 Ensembl
RGD		 PMID:16989814 GO_REF:0000107 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:25772147 RGD:13782257 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular response to stimulus 8963
        cellular response to biotic stimulus 388
          ER overload response 14
            detection of endoplasmic reticulum overloading 0
            positive regulation of autophagy in response to ER overload 3
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            intracellular signal transduction 3189
              ER-nucleus signaling pathway 52
                ER overload response 14
                  detection of endoplasmic reticulum overloading 0
                  positive regulation of autophagy in response to ER overload 3
paths to the root