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ONTOLOGY REPORT - ANNOTATIONS

Term:PERK-mediated unfolded protein response
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Accession:GO:0036499 term browser browse the term
Definition:The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
Synonyms:exact_synonym: PERK branch of UPR;   PKR-like ER kinase signal transduction;   UPR signaling by PERK stress sensor;   endoplasmic reticulum unfolded protein response; PERK signaling
 broad_synonym: PERK signal transduction pathway
 related_synonym: EIF2AK3-mediated unfolded protein response;   PERK signaling in response to endoplasmic reticulum stress;   eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response
 xref: Reactome:R-HSA-381042 "PERK regulates gene expression"


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PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:31023583)
(PMID:12667446), (PMID:14729979) 		UniProt
Ensembl
RGD		 PMID:12667446 PMID:14729979 PMID:31023583 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
IEA 		(PMID:10026192), (PMID:25925385), (PMID:31023583), (PMID:39116259)
GO_REF:0000107
(PMID:10882126), (PMID:14729979), (PMID:16418533), (PMID:17707796), (PMID:21954288), (PMID:29386355) 		RGD
Ensembl		 PMID:10026192 PMID:10882126 PMID:14729979 PMID:16418533 PMID:17707796 More... GO_REF:0000107 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:31023583), (PMID:33384352) 		UniProt
Ensembl
RGD		 PMID:31023583 PMID:33384352 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO
IEA 		(PMID:14517290)
GO_REF:0000107 		RGD
Ensembl		 PMID:14517290 GO_REF:0000107 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO
IEA 		(PMID:33384352)
GO_REF:0000107 		RGD
Ensembl		 PMID:33384352 GO_REF:0000107 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rpap2 RNA polymerase II associated protein 2 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:30118681)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:30118681 GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO
IEA 		MGI:4456438 (PMID:28797121)
GO_REF:0000107 		RGD
Ensembl		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27030769) RGD PMID:27030769 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21954288) 		Ensembl
RGD		 PMID:21954288 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21954288) 		Ensembl
RGD		 PMID:21954288 GO_REF:0000107 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO (PMID:21954288) RGD PMID:21954288 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A involved_in ISO
IEA
ISS 		(PMID:39116259)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:39116259 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO
IEA 		(PMID:30842412)
GO_REF:0000107 		RGD
Ensembl		 PMID:30842412 GO_REF:0000107 NCBI chr 3:138,315,006...138,336,691
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO
IEA 		(PMID:11907036)
GO_REF:0000107 		RGD
Ensembl		 PMID:11907036 GO_REF:0000107 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IEA
IBA 		(PMID:14676213)
GO_REF:0000107
GO_REF:0000033
UniProtKB:O55033 (PMID:14676213) 		RGD
Ensembl
GO_Central		 PMID:14676213 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IEA
IBA 		UniProtKB:Q99M51 (PMID:14676213)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:14676213 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA
IEA 		(PMID:21216966)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:21216966 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO
IEA 		(PMID:23220234)
GO_REF:0000107 		RGD
Ensembl		 PMID:23220234 GO_REF:0000107 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:26015568)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:26015568 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21216966) 		Ensembl
RGD		 PMID:21216966 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS
IEA 		(PMID:26268696)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        intracellular signal transduction 3197
          ER-nucleus signaling pathway 52
            PERK-mediated unfolded protein response 21
              negative regulation of PERK-mediated unfolded protein response 10
              positive regulation of PERK-mediated unfolded protein response 4
              regulation of PERK-mediated unfolded protein response + 14
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          signal transduction 7313
            intracellular signal transduction 3197
              intracellular signaling cassette 2057
                integrated stress response signaling 29
                  PERK-mediated unfolded protein response 21
                    negative regulation of PERK-mediated unfolded protein response 10
                    positive regulation of PERK-mediated unfolded protein response 4
                    regulation of PERK-mediated unfolded protein response + 14
paths to the root