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SREBP-SCAP complex retention in endoplasmic reticulum (GO:0036316)
Annotations: Rat: (3) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: (2) Pig: (2)
Parent Terms Term With Siblings Child Terms
cellular response to cholesterol  
cellular response to diosgenin 
cellular response to ecdysone +   
cellular response to ergosterol  
negative regulation of SREBP signaling pathway in response to increased oxygen levels 
negative regulation of sterol regulatory element binding protein cleavage 
protein retention in ER lumen  
SREBP-SCAP complex retention in endoplasmic reticulum  
Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.

Definition Sources: GOC:bf, PMID:16525117

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