SREBP-SCAP complex retention in endoplasmic reticulum - Ontology Browser

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SREBP-SCAP complex retention in endoplasmic reticulum (GO:0036316)
Annotations: Rat: (3) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: (2) Pig: (2)

Parent Terms

Term With Siblings

Child Terms

cellular response to sterol + part-of

maintenance of protein localization in endoplasmic reticulum + is-a

negative regulation of SREBP signaling pathway + is-a

cellular response to cholesterol

cellular response to diosgenin

cellular response to ecdysone +

cellular response to ergosterol

negative regulation of SREBP signaling pathway in response to increased oxygen levels

protein retention in ER lumen

SREBP-SCAP complex retention in endoplasmic reticulum

Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.

Synonyms
Definition Sources:	GOC:bf, PMID:16525117

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