Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:SREBP signaling pathway
go back to main search page
Accession:GO:0032933 term browser browse the term
Definition:The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Synonyms:exact_synonym: ER to nucleus sterol response pathway;   ER-nuclear sterol response pathway;   SREBP signalling;   SREBP target gene transcriptional activation;   SREBP-mediated signalling pathway;   endoplasmic reticulum to nucleus sterol response pathway;   endoplasmic reticulum-nuclear sterol response pathway;   positive regulation of sterol regulatory element binding protein target gene transcription;   positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response;   sterol depletion response, SREBP target gene transcriptional activation;   sterol response element binding protein signaling pathway;   up regulation of sterol regulatory element binding protein target gene transcription;   upregulation of sterol regulatory element binding protein target gene transcription
 narrow_synonym: activation of sterol regulatory element binding protein target gene transcription;   positive regulation of transcription via sterol regulatory element binding;   positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway;   stimulation of sterol regulatory element binding protein target gene transcription
 broad_synonym: sterol regulatory element binding protein target gene transcriptional activation
 related_synonym: SREBP-mediated signaling pathway
 alt_id: GO:0006994;   GO:0030967;   GO:0035104


show annotations for term's descendants           Sort by:
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IEA
IBA 		(PMID:16112081)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16112081 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO
IEA 		(PMID:18852460)
GO_REF:0000107 		RGD
Ensembl		 PMID:18852460 GO_REF:0000107 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA
IBA 		(PMID:24217618)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:24217618 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO
IBA 		(PMID:24217618)
GO_REF:0000033 		RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA 		(PMID:12242332), (PMID:32322062)
GO_REF:0000033 		RGD
GO_Central		 PMID:12242332 PMID:32322062 GO_REF:0000033 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO 		GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:12242332), (PMID:17428920), (PMID:32322062) 		UniProt
GO_Central
Ensembl
RGD		 PMID:12242332 PMID:17428920 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
G Scap SREBF chaperone involved_in ISO
IEA
ISS 		(PMID:11726962), (PMID:32322062)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000024 		RGD
InterPro
Ensembl
UniProt		 PMID:11726962 PMID:32322062 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
IEA
ISS 		(PMID:27614840)
GO_REF:0000107
GO_REF:0000024
(PMID:32322062) 		RGD
Ensembl
UniProt		 PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:32322062)
(PMID:27614840) 		Ensembl
UniProt
RGD		 PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir96 microRNA 96 involved_in ISO (PMID:30460077) RGD PMID:30460077 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO
IEA 		(PMID:26311497)
GO_REF:0000107 		RGD
Ensembl		 PMID:26311497 GO_REF:0000107 NCBI chr14:12,766,539...12,796,461
Ensembl chr14:12,462,563...12,479,994 		JBrowse link
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO
IEA 		(PMID:32111832)
GO_REF:0000002 		RGD
InterPro		 PMID:32111832 GO_REF:0000002 NCBI chr12:38,306,227...38,329,175
Ensembl chr12:38,297,837...38,329,138 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO
IEA 		(PMID:29420538)
GO_REF:0000107 		RGD
Ensembl		 PMID:29420538 GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IEA 		(PMID:22863805)
GO_REF:0000107 		RGD
Ensembl		 PMID:22863805 GO_REF:0000107 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO
IEA 		MGI:4456438 (PMID:28797121)
GO_REF:0000107 		RGD
Ensembl		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in ISO
IBA 		(PMID:12202038), (PMID:15899885), (PMID:32322062)
GO_REF:0000033 		RGD
GO_Central		 PMID:12202038 PMID:15899885 PMID:32322062 GO_REF:0000033 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO 		GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:15899885), (PMID:32322062) 		UniProt
GO_Central
Ensembl
RGD		 PMID:15899885 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    response to stimulus 11082
      response to stress 4353
        response to sterol depletion 20
          cellular response to sterol depletion 18
            SREBP signaling pathway 17
              negative regulation of SREBP signaling pathway + 3
              positive regulation of SREBP signaling pathway + 4
              regulation of SREBP signaling pathway + 9
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          signal transduction 7313
            intracellular signal transduction 3197
              ER-nucleus signaling pathway 52
                SREBP signaling pathway 17
                  negative regulation of SREBP signaling pathway + 3
                  positive regulation of SREBP signaling pathway + 4
                  regulation of SREBP signaling pathway + 9
paths to the root