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ONTOLOGY REPORT - ANNOTATIONS


Term:SREBP signaling pathway
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Accession:GO:0032933 term browser browse the term
Definition:A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Synonyms:exact_synonym: ER to nucleus sterol response pathway;   ER-nuclear sterol response pathway;   SREBP signalling;   SREBP target gene transcriptional activation;   SREBP-mediated signalling pathway;   endoplasmic reticulum to nucleus sterol response pathway;   endoplasmic reticulum-nuclear sterol response pathway;   positive regulation of sterol regulatory element binding protein target gene transcription;   positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response;   sterol depletion response, SREBP target gene transcriptional activation;   sterol response element binding protein signaling pathway;   up regulation of sterol regulatory element binding protein target gene transcription;   upregulation of sterol regulatory element binding protein target gene transcription
 narrow_synonym: activation of sterol regulatory element binding protein target gene transcription;   positive regulation of transcription via sterol regulatory element binding;   positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway;   stimulation of sterol regulatory element binding protein target gene transcription
 broad_synonym: sterol regulatory element binding protein target gene transcriptional activation
 related_synonym: SREBP-mediated signaling pathway
 alt_id: GO:0006994;   GO:0030967;   GO:0035104


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SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Arhgef10l Rho guanine nucleotide exchange factor 10 like JBrowse link 5 159,018,373 159,089,383 RGD:1624291
RGD:13792537
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
RGD:13792537
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
RGD:13792537
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:13792537
RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:13792537
RGD:1600115
RGD:1624291
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291
RGD:1600115
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1624291
RGD:1600115
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1600115
RGD:1624291
positive regulation of SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spring1 SREBF pathway regulator in golgi 1 JBrowse link 12 43,920,564 43,940,798 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lpcat3 lysophosphatidylcholine acyltransferase 3 JBrowse link 4 157,181,722 157,222,997 RGD:1600115
RGD:1624291
regulation of SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:13792537
RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:13792537
RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      signal transduction 6968
        ER-nucleus signaling pathway 41
          SREBP signaling pathway 16
            negative regulation of SREBP signaling pathway + 3
            positive regulation of SREBP signaling pathway + 3
            regulation of SREBP signaling pathway + 8
            sterol regulatory element binding protein cleavage + 1
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      cellular metabolic process 10917
        cellular aromatic compound metabolic process 5567
          nucleobase-containing compound metabolic process 5344
            nucleic acid metabolic process 4850
              RNA metabolic process 4347
                regulation of RNA metabolic process 3510
                  regulation of RNA biosynthetic process 3237
                    regulation of nucleic acid-templated transcription 3232
                      regulation of transcription, DNA-templated 3182
                        positive regulation of transcription, DNA-templated 1686
                          positive regulation of transcription by RNA polymerase II 1375
                            SREBP signaling pathway 16
                              negative regulation of SREBP signaling pathway + 3
                              positive regulation of SREBP signaling pathway + 3
                              regulation of SREBP signaling pathway + 8
                              sterol regulatory element binding protein cleavage + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.