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ONTOLOGY REPORT - ANNOTATIONS


Term:SREBP signaling pathway
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Accession:GO:0032933 term browser browse the term
Definition:A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Synonyms:exact_synonym: ER to nucleus sterol response pathway;   ER-nuclear sterol response pathway;   SREBP signalling;   SREBP target gene transcriptional activation;   SREBP-mediated signalling pathway;   endoplasmic reticulum to nucleus sterol response pathway;   endoplasmic reticulum-nuclear sterol response pathway;   positive regulation of sterol regulatory element binding protein target gene transcription;   positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response;   sterol depletion response, SREBP target gene transcriptional activation;   sterol response element binding protein signaling pathway;   up regulation of sterol regulatory element binding protein target gene transcription;   upregulation of sterol regulatory element binding protein target gene transcription
 narrow_synonym: activation of sterol regulatory element binding protein target gene transcription;   positive regulation of transcription via sterol regulatory element binding;   positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway;   stimulation of sterol regulatory element binding protein target gene transcription
 broad_synonym: sterol regulatory element binding protein target gene transcriptional activation
 related_synonym: SREBP-mediated signaling pathway
 alt_id: GO:0006994;   GO:0030967;   GO:0035104



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SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:67,330,588...67,331,346 JBrowse link
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IBA
(PMID:16112081)
PMID:21873635
RGD PMID:16112081 PMID:21873635 RGD:13792537 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:3815371 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:3815371 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618 PMID:21873635 RGD:13792537 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in IBA
ISO
PMID:21873635
(PMID:24217618)
RGD PMID:24217618 PMID:21873635 RGD:13792537 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA
(PMID:12242332), (PMID:32322062)
PMID:21873635
RGD PMID:12242332 PMID:32322062 PMID:21873635 RGD:13792537 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:12242332), (PMID:17428920), (PMID:32322062)
UniProt
RGD
PMID:12242332 PMID:17428920 PMID:32322062 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Scap SREBF chaperone involved_in ISO
ISS
(PMID:11726962), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:11726962 PMID:32322062 GO_REF:0000024 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
ISS
(PMID:32322062)
GO_REF:0000024
(PMID:27614840)
RGD
UniProt
PMID:27614840 PMID:32322062 GO_REF:0000024 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27614840)
(PMID:32322062)
Ensembl
UniProt
RGD
PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)
RGD PMID:32111832 MGI:6401656 NCBI chr12:38,308,731...38,329,175
Ensembl chr12:38,297,837...38,329,138
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:6120228 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5927299|PMID:28846071)
UniProt
RGD
PMID:28846071 GO_REF:0000024 MGI:5927299 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) RGD PMID:22863805 MGI:6276494 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:67,330,588...67,331,346 JBrowse link
G Insig1 insulin induced gene 1 involved_in IBA
ISO
PMID:21873635
(PMID:12202038), (PMID:32322062)
RGD PMID:12202038 PMID:32322062 PMID:21873635 RGD:13792537 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:32322062)
UniProt
RGD
PMID:32322062 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      signal transduction 6859
        ER-nucleus signaling pathway 44
          SREBP signaling pathway 16
            negative regulation of SREBP signaling pathway + 3
            positive regulation of SREBP signaling pathway + 2
            regulation of SREBP signaling pathway + 7
            sterol regulatory element binding protein cleavage + 1
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          signal transduction 6859
            ER-nucleus signaling pathway 44
              SREBP signaling pathway 16
                negative regulation of SREBP signaling pathway + 3
                positive regulation of SREBP signaling pathway + 2
                regulation of SREBP signaling pathway + 7
                sterol regulatory element binding protein cleavage + 1
paths to the root